دورية أكاديمية
أعرض في EDS

Utility of iliac crest tetracycline-labelled bone biopsy in osteoporosis and metabolic bone disease: An evaluation of 95 cases over a period of 25 years.

التفاصيل البيبلوغرافية
العنوان: Utility of iliac crest tetracycline-labelled bone biopsy in osteoporosis and metabolic bone disease: An evaluation of 95 cases over a period of 25 years.
المؤلفون: Colazo JM; Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN, USA., Quirion J; Division of Musculoskeletal Oncology, Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Judice AD; Division of Musculoskeletal Oncology, Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Halpern J; Division of Musculoskeletal Oncology, Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Schwartz HS; Division of Musculoskeletal Oncology, Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Tanner SB; Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Lawrenz JM; Division of Musculoskeletal Oncology, Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Dahir KM; Department of Medicine, Division of Endocrinology and Diabetes, Vanderbilt University Medical Center, Nashville, TN, USA., Holt GE; Division of Musculoskeletal Oncology, Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
المصدر: Bone reports [Bone Rep] 2023 Sep 24; Vol. 19, pp. 101715. Date of Electronic Publication: 2023 Sep 24 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101646176 Publication Model: eCollection Cited Medium: Print ISSN: 2352-1872 (Print) Linking ISSN: 23521872 NLM ISO Abbreviation: Bone Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Philadelphia] : Elsevier Inc., [2015]-
مستخلص: Background: Metabolic bone diseases (MBD) are typically diagnosed by non-invasive imaging and clinical biomarkers. However, imaging does not provide structural information, and biomarkers can be transiently affected by many systemic factors. Bone biopsy and pathologic evaluation is the gold standard for diagnosis of MBD, however, it is rarely utilized. We describe our technique for iliac crest tetracycline-labelled bone using a cannulated drill and assess the utility of bone biopsies to provide diagnostic and therapeutic guidance.
Methods: In the 25-year period between March 1998 and January 2023, a total of 95 bone biopsies were performed on 94 patients for an osteological indication at Vanderbilt University Medical Center (VUMC). Patient demographics, bone biopsy indications, complications, diagnostic utility, and subsequent therapeutic guidance were retrospectively reviewed and analyzed.
Results: The procedure had minimal complications and was well tolerated by patients. This technique provided good quality specimens for pathology, which helped establish a diagnosis and treatment change in most patients. Patients that had biopsy-guided treatment alterations showed significant increases in Dual-Energy X-ray Absorptiometry (DEXA) bone mineral density (BMD) scores post-biopsy and subsequent treatment.
Conclusion: Despite scientific and technological progress in non-invasive diagnostic imaging, clinical biomarkers, and procedures for MBD, there remains a small but significant subset of patients who may benefit from inclusion of tetracycline-labelled bone biopsy into the diagnostic and therapeutic picture. Future prospective comparison studies are warranted.
Mini Abstract: Tetracycline-labelled bone biopsies are under-utilized. Biopsy led to a histological diagnosis and ensuing treatment alteration in most patients with significant increases in bone mineral density. The biopsy procedure used herein provided good specimens with low pain/adverse events. Bone biopsy remains a valuable tool in a small, though significant, subset of patients.
Competing Interests: Juan M. Colazo, Julia Quirion, Anthony D. Judice, Jennifer Halpern, Herbert S. Schwartz, S. Bobo Tanner, Kathryn M. Dahir, Joshua M. Lawrenz, and Ginger E. Holt declare that they have no conflict of interest.
(© 2023 The Authors.)
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فهرسة مساهمة: Keywords: Antibiotic-labelled bone biopsy; Bone biopsy; Metabolic bone disease; Osteomalacia; Osteoporosis; Tetracycline labelling
تواريخ الأحداث: Date Created: 20231009 Latest Revision: 20231030
رمز التحديث: 20231031
مُعرف محوري في PubMed: PMC10558706
DOI: 10.1016/j.bonr.2023.101715
PMID: 37811524
قاعدة البيانات: MEDLINE
الوصف
تدمد:2352-1872
DOI:10.1016/j.bonr.2023.101715