دورية أكاديمية
Comparison of the radioprotective effects of the liposomal forms of five natural radioprotectants in alleviating the adverse effects of ionising irradiation on human lymphocytes and skin cells in radiotherapy.
| العنوان: | Comparison of the radioprotective effects of the liposomal forms of five natural radioprotectants in alleviating the adverse effects of ionising irradiation on human lymphocytes and skin cells in radiotherapy. |
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| المؤلفون: | Pham ND; Laboratory of Tissue Engineering and Biomedical Materials, University of Science, Ho Chi Minh City, Vietnam.; Vietnam National University, Ho Chi Minh City, Vietnam.; Center of Radiation Technology and Biotechnology, Nuclear Research Institute, Da Lat, Vietnam., Nguyen TH; Department of Biology, Dalat University, Da Lat, Vietnam., Vu NB; Center of Radiation Technology and Biotechnology, Nuclear Research Institute, Da Lat, Vietnam., Tran TN; Center of Radiation Technology and Biotechnology, Nuclear Research Institute, Da Lat, Vietnam., Pham BN; Center of Radiation Technology and Biotechnology, Nuclear Research Institute, Da Lat, Vietnam., Le HS; VN-UK Institute for Research and Executive Education, The University of Danang, Da Nang, Vietnam., Vo KH; Department of Health of Lam-Dong Province, Da Lat, Vietnam., Le XC; Center of Radiation Technology and Biotechnology, Nuclear Research Institute, Da Lat, Vietnam., Tran LB; Laboratory of Tissue Engineering and Biomedical Materials, University of Science, Ho Chi Minh City, Vietnam., Nguyen MH; Center of Radiation Technology and Biotechnology, Nuclear Research Institute, Da Lat, Vietnam. |
| المصدر: | Journal of microencapsulation [J Microencapsul] 2023 Dec; Vol. 40 (8), pp. 613-629. Date of Electronic Publication: 2023 Nov 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8500513 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5246 (Electronic) Linking ISSN: 02652048 NLM ISO Abbreviation: J Microencapsul Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: London [England] ; Philadelphia : Taylor & Francis, c1984- |
| مواضيع طبية MeSH: | Liposomes* , Curcumin*/pharmacology, Humans ; Resveratrol ; Skin ; Lymphocytes |
| مستخلص: | This study aims to evaluate the radioprotective effects of liposomes encapsulating curcumin (Lip-CUR), silibinin (Lip-SIL), α-tocopherol (Lip-TOC), quercetin (Lip-QUE) and resveratrol (Lip-RES) in alleviating the adverse effects of ionising irradiation on human lymphoctyes and skin cells in radiotherapy. Liposomes encapsulating the above natural radioprotectants (Lip-NRPs) were prepared by the film hydration method combined with sonication. Their radioprotective effects for the cells against X-irradiation was evaluated using trypan-blue assay and γ-H2AX assay. All prepared Lip-NRPs had a mean diameter less than 240 nm, polydispersity index less than 0.32, and zeta potential more than -23 mV. Among them, the radioprotective effect of Lip-RES was lowest, while that of Lip-QUE was highest. Lip-SIL also exhibited a high radioprotective effect despite its low DPPH-radical scavenging activity (12.9%). The radioprotective effects of Lip-NRPs do not solely depend on the free radical scavenging activity of NRPs but also on their ability to activate cellular mechanisms. |
| فهرسة مساهمة: | Keywords: Comparison; human fibroblasts; liposomes; lymphocytes; natural radioprotectants; radioprotection |
| المشرفين على المادة: | 0 (Liposomes) Q369O8926L (Resveratrol) IT942ZTH98 (Curcumin) |
| تواريخ الأحداث: | Date Created: 20231010 Date Completed: 20231113 Latest Revision: 20231113 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/02652048.2023.2268705 |
| PMID: | 37815151 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1464-5246 |
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| DOI: | 10.1080/02652048.2023.2268705 |