دورية أكاديمية
Involvement of A13 dopaminergic neurons in prehensile movements but not reward in the rat.
| العنوان: | Involvement of A13 dopaminergic neurons in prehensile movements but not reward in the rat. |
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| المؤلفون: | Garau C; Department of Neuroscience, Psychology & Behaviour, University of Leicester, University Road, Leicester LE1 9HN, UK. Electronic address: celiagarau@gmail.com., Hayes J; Department of Neuroscience, Psychology & Behaviour, University of Leicester, University Road, Leicester LE1 9HN, UK., Chiacchierini G; Department of Neuroscience, Psychology & Behaviour, University of Leicester, University Road, Leicester LE1 9HN, UK; Department of Physiology and Pharmacology, La Sapienza University of Rome, 00185 Rome, Italy; Laboratory of Neuropsychopharmacology, Santa Lucia Foundation, 00143 Rome, Italy., McCutcheon JE; Department of Neuroscience, Psychology & Behaviour, University of Leicester, University Road, Leicester LE1 9HN, UK; Department of Psychology, UiT The Arctic University of Norway, Huginbakken 32, 9037 Tromsø, Norway., Apergis-Schoute J; Department of Neuroscience, Psychology & Behaviour, University of Leicester, University Road, Leicester LE1 9HN, UK; Department of Biological and Experimental Psychology, Queen Mary University of London, London E1 4NS, UK. Electronic address: j.apergis-schoute@qmul.ac.uk. |
| المصدر: | Current biology : CB [Curr Biol] 2023 Nov 20; Vol. 33 (22), pp. 4786-4797.e4. Date of Electronic Publication: 2023 Oct 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge, MA : Cell Press Original Publication: London, UK : Current Biology Ltd., c1991- |
| مواضيع طبية MeSH: | Dopaminergic Neurons* , Reticular Formation*, Rats ; Animals ; Reward |
| مستخلص: | Tyrosine hydroxylase (TH)-containing neurons of the dopamine (DA) cell group A13 are well positioned to impact known DA-related functions as their descending projections innervate target regions that regulate vigilance, sensory integration, and motor execution. Despite this connectivity, little is known regarding the functionality of A13-DA circuits. Using TH-specific loss-of-function methodology and techniques to monitor population activity in transgenic rats in vivo, we investigated the contribution of A13-DA neurons in reward and movement-related actions. Our work demonstrates a role for A13-DA neurons in grasping and handling of objects but not reward. A13-DA neurons responded strongly when animals grab and manipulate food items, whereas their inactivation or degeneration prevented animals from successfully doing so-a deficit partially attributed to a reduction in grip strength. By contrast, there was no relation between A13-DA activity and food-seeking behavior when animals were tested on a reward-based task that did not include a reaching/grasping response. Motivation for food was unaffected, as goal-directed behavior for food items was in general intact following A13 neuronal inactivation/degeneration. An anatomical investigation confirmed that A13-DA neurons project to the superior colliculus (SC) and also demonstrated a novel A13-DA projection to the reticular formation (RF). These results establish a functional role for A13-DA neurons in prehensile actions that are uncoupled from the motivational factors that contribute to the initiation of forelimb movements and help position A13-DA circuits into the functional framework regarding centrally located DA populations and their ability to coordinate movement. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: A13; dopamine; grasping; neural circuits; reticular formation; skilled forelimb movements; superior colliculus; zona incerta |
| تواريخ الأحداث: | Date Created: 20231010 Date Completed: 20231123 Latest Revision: 20240207 |
| رمز التحديث: | 20240207 |
| DOI: | 10.1016/j.cub.2023.09.044 |
| PMID: | 37816347 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1879-0445 |
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| DOI: | 10.1016/j.cub.2023.09.044 |