دورية أكاديمية
Equine maternal aging affects the metabolomic profile of oocytes and follicular cells during different maturation time points.
| العنوان: | Equine maternal aging affects the metabolomic profile of oocytes and follicular cells during different maturation time points. |
|---|---|
| المؤلفون: | Catandi GD; Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States., Bresnahan DR; Department of Animal Sciences, Berry College, Mount Berry, GA, United States., Peters SO; Department of Animal Sciences, Berry College, Mount Berry, GA, United States., Fresa KJ; Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States., Maclellan LJ; Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States., Broeckling CD; Proteomic and Metabolomics Core Facility, Colorado State University, Fort Collins, CO, United States., Carnevale EM; Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States. |
| المصدر: | Frontiers in cell and developmental biology [Front Cell Dev Biol] 2023 Sep 25; Vol. 11, pp. 1239154. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2013]- |
| مستخلص: | Introduction: Oocyte quality and fertility decline with advanced maternal age. During maturation within the ovarian follicle, the oocyte relies on the associated somatic cells, specifically cumulus and granulosa cells, to acquire essential components for developmental capacity. Methods: A nontargeted metabolomics approach was used to investigate the effects of mare age on different cell types within the dominant, follicular-phase follicle at three time points during maturation. Metabolomic analyses from single oocytes and associated cumulus and granulosa cells allowed correlations of metabolite abundance among cell types. Results and Discussion: Overall, many of the age-related changes in metabolite abundance point to Impaired mitochondrial metabolic function and oxidative stress in oocytes and follicular cells. Supporting findings include a higher abundance of glutamic acid and triglycerides and lower abundance of ceramides in oocytes and somatic follicular cells from old than young mares. Lower abundance of alanine in all follicular cell types from old mares, suggests limited anaerobic energy metabolism. The results also indicate impaired transfer of carbohydrate and free fatty acid substrates from cumulus cells to the oocytes of old mares, potentially related to disruption of transzonal projections between the cell types. The identification of age-associated alterations in the abundance of specific metabolites and their correlations among cells contribute to our understanding of follicular dysfunction with maternal aging. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Catandi, Bresnahan, Peters, Fresa, Maclellan, Broeckling and Carnevale.) |
| References: | Reproduction. 2022 Jan 28;163(4):183-198. (PMID: 37379450) Reprod Fertil Dev. 2019 Jan;31(12):1812-1822. (PMID: 31630724) Curr Biol. 2018 Apr 2;28(7):1124-1131.e3. (PMID: 29576478) Biol Reprod. 2022 Oct 11;107(4):916-927. (PMID: 35746896) J Proteomics. 2019 May 30;200:134-143. (PMID: 30951908) Q Rev Biophys. 2013 Feb;46(1):1-132. (PMID: 23318152) Gamete Res. 1988 Oct;21(2):157-68. (PMID: 3229728) Biol Reprod. 2022 Feb 22;106(2):366-377. (PMID: 35094043) Biol Reprod. 2019 Apr 1;100(4):971-981. (PMID: 30476005) Front Aging Neurosci. 2018 Apr 27;10:124. (PMID: 29755342) Vet Clin North Am Equine Pract. 2016 Dec;32(3):379-399. (PMID: 27726987) Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12654-8. (PMID: 26275233) Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1511-8. (PMID: 22473000) Anal Chem. 2016 Sep 20;88(18):9226-34. (PMID: 27560453) Theriogenology. 2019 May;130:163-176. (PMID: 30921545) Reprod Biomed Online. 2008 Jun;16(6):859-68. (PMID: 18549697) Biomed Sci. 1990;1(6):591-6. (PMID: 2132943) Hum Reprod Update. 2021 Jan 4;27(1):27-47. (PMID: 33020823) Reprod Biol Endocrinol. 2022 Feb 24;20(1):37. (PMID: 35209923) Turk J Obstet Gynecol. 2022 Sep 23;19(3):207-214. (PMID: 36149261) Commun Biol. 2023 Mar 11;6(1):259. (PMID: 36906698) Eur J Obstet Gynecol Reprod Biol. 2009 Dec;147(2):120-3. (PMID: 19800728) Semin Reprod Med. 2009 Jan;27(1):32-42. (PMID: 19197803) Anal Chem. 2006 Feb 1;78(3):779-87. (PMID: 16448051) Hum Reprod. 2017 Dec 01;32(12):2465-2473. (PMID: 29045673) Reproduction. 2014 Jul;148(1):R15-27. (PMID: 24760880) Metabolism. 2010 Aug;59(8):1145-55. (PMID: 20045541) Anim Nutr. 2017 Mar;3(1):7-10. (PMID: 29767087) Fertil Steril. 2022 Aug;118(2):393-404. (PMID: 35637023) Aging Cell. 2013 Feb;12(1):42-9. (PMID: 23061827) Mech Ageing Dev. 2013 Jan-Feb;134(1-2):43-52. (PMID: 23246342) Reprod Fertil Dev. 2022 Sep;34(15):957-970. (PMID: 36031717) J Assist Reprod Genet. 2019 Mar;36(3):395-402. (PMID: 30467617) Essays Biochem. 2020 Sep 23;64(3):579-589. (PMID: 32579188) Biol Reprod. 2022 Feb 22;106(2):351-365. (PMID: 34982142) Sci Rep. 2020 Feb 26;10(1):3493. (PMID: 32103136) Theriogenology. 2009 Mar 15;71(5):780-8. (PMID: 19004489) Curr Top Dev Biol. 2007;77:51-83. (PMID: 17222700) Reproduction. 2012 Jan 1;143(1):1-10. (PMID: 22046054) Analyst. 2019 Feb 25;144(5):1527-1534. (PMID: 30663723) Biol Reprod. 1985 Dec;33(5):1041-9. (PMID: 4074802) Cells. 2021 Sep 02;10(9):. (PMID: 34571941) Reproduction. 2002 Nov;124(5):675-81. (PMID: 12417006) Front Physiol. 2022 Jan 27;12:800739. (PMID: 35153812) Hum Reprod. 2023 Sep 06;:. (PMID: 37671592) Reproduction. 2021 Apr;161(4):399-409. (PMID: 33539317) Sci Rep. 2017 Jun 1;7(1):2645. (PMID: 28572619) Dev Reprod. 2016 Jun;20(2):149-55. (PMID: 27660830) Theriogenology. 2008 Jan 1;69(1):23-30. (PMID: 17976712) J Reprod Dev. 2020 Feb 14;66(1):1-7. (PMID: 31787727) Reprod Fertil Dev. 2018 Jan;31(1):1-9. (PMID: 32188537) Curr Opin Obstet Gynecol. 2015 Jun;27(3):175-81. (PMID: 25719756) Biol Reprod. 2005 Aug;73(2):351-7. (PMID: 15843493) Reprod Sci. 2022 Apr;29(4):1343-1356. (PMID: 34374964) J Assist Reprod Genet. 2022 Dec;39(12):2737-2746. (PMID: 36322230) Reprod Fertil Dev. 2015 Jul;27(6):906-13. (PMID: 25775380) Saudi Pharm J. 2013 Oct;21(4):337-43. (PMID: 24227952) Reproduction. 2002 Aug;124(2):241-8. (PMID: 12141937) Theriogenology. 2020 Jan 15;142:207-215. (PMID: 31614287) J Assist Reprod Genet. 2011 Sep;28(9):773-83. (PMID: 21617930) Anal Chem. 2014 Jul 15;86(14):6812-7. (PMID: 24927477) J Reprod Infertil. 2020 Oct-Dec;21(4):259-268. (PMID: 33209742) Anesth Analg. 2018 May;126(5):1763-1768. (PMID: 29481436) Int J Dev Biol. 2012;56(10-12):799-808. (PMID: 23417402) Biol Reprod. 2022 Jul 25;107(1):54-61. (PMID: 35470861) J Equine Vet Sci. 2020 Jun;89:103022. (PMID: 32563447) Adv Exp Med Biol. 2012;763:186-92. (PMID: 23397625) Theriogenology. 2019 Mar 15;127:80-87. (PMID: 30677595) FASEB J. 2005 May;19(7):860-2. (PMID: 15728664) Curr Top Dev Biol. 2007;77:21-49. (PMID: 17222699) Exp Mol Med. 2020 Sep;52(9):1496-1516. (PMID: 32943735) Reprod Fertil Dev. 2019 Mar;31(3):570-578. (PMID: 30423285) Reprod Health. 2021 Jan 19;18(1):13. (PMID: 33468143) Dev Biol. 2005 Mar 1;279(1):20-30. (PMID: 15708555) Reprod Fertil Dev. 2014 Jan;26(2):337-45. (PMID: 23514964) Experientia. 1978 Jun 15;34(6):800-2. (PMID: 658309) |
| فهرسة مساهمة: | Keywords: age; cumulus; follicle; granulosa; mare; maturation; metabolome; oocyte |
| تواريخ الأحداث: | Date Created: 20231011 Latest Revision: 20231018 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10561129 |
| DOI: | 10.3389/fcell.2023.1239154 |
| PMID: | 37818125 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-634X |
|---|---|
| DOI: | 10.3389/fcell.2023.1239154 |