دورية أكاديمية
أعرض في EDS

Cellular Prion protein moonlights vascular smooth muscle cell fate: Surveilled by trophoblast cells.

التفاصيل البيبلوغرافية
العنوان: Cellular Prion protein moonlights vascular smooth muscle cell fate: Surveilled by trophoblast cells.
المؤلفون: Bose R; Division of Cell Biology and Physiology, CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India., Jana SS; Division of Cell Biology and Physiology, CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India., Ain R; Division of Cell Biology and Physiology, CSIR-Indian Institute of Chemical Biology, Kolkata, West Bengal, India.
المصدر: Journal of cellular physiology [J Cell Physiol] 2023 Dec; Vol. 238 (12), pp. 2794-2811. Date of Electronic Publication: 2023 Oct 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0050222 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4652 (Electronic) Linking ISSN: 00219541 NLM ISO Abbreviation: J Cell Physiol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Wiley-Liss
Original Publication: Philadelphia, Wistar Institute of Anatomy and Biology.
مواضيع طبية MeSH: Muscle, Smooth, Vascular*/metabolism , Prions*/genetics , Prions*/metabolism, Animals ; Female ; Pregnancy ; Rats ; Cell Movement/genetics ; Cells, Cultured ; Endothelial Cells/metabolism ; Myocytes, Smooth Muscle/metabolism ; Prion Proteins/genetics ; Prion Proteins/metabolism ; Trophoblasts/metabolism ; Uterine Artery ; Humans ; Rats, Sprague-Dawley
مستخلص: Uterine spiral artery remodeling (uSAR) is a hallmark of hemochorial placentation. Compromised uSAR leads to adverse pregnancy outcomes. Salient developmental events involved in uSAR are active areas of research and include (a) trophendothelial cell invasion into the spiral arteries, selected demise of endothelial cells; (b) de-differentiation of vascular smooth muscle cells (VSMC); and (c) migration and/or death of VSMCs surrounding spiral arteries. Here we demonstrated that cellular prion (PRNP) is expressed in the rat metrial gland, the entry point of spiral arteries with the highest expression on E16.5, the day at which trophoblast invasion peaks. PRNP is expressed in VSMCs that drift away from the arterial wall. RNA interference of Prnp functionally restricted migration and invasion of rat VSMCs. Furthermore, PRNP interacted with two migration-promoting factors, focal adhesion kinase (FAK) and platelet-derived growth factor receptor-β (PDGFR-β), forming a ter-molecular complex in both the metrial gland and A7r5 cells. The presence of multiple putative binding site of odd skipped related-1 (OSR1) transcription factor on the Prnp promoter was observed using in silico promoter analysis. Ectopic overexpression of OSR1 increased, and knockdown of OSR1 decreased expression of PRNP in VSMCs. Coculture of VSMCs with rat primary trophoblast cells decreased the levels of OSR1 and PRNP. Interestingly, PRNP knockdown led to apoptotic death in ~9% of VSMCs and activated extrinsic apoptotic pathways. PRNP interacts with TRAIL-receptor DR4 and protects VSMCs from TRAIL-mediated apoptosis. These results highlight the biological functions of PRNP in VSMC cell-fate determination during uteroplacental development, an important determinant of healthy pregnancy outcome.
(© 2023 Wiley Periodicals LLC.)
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معلومات مُعتمدة: Indian Council of Medical Research
فهرسة مساهمة: Keywords: TRAIL; apoptosis; cell migration; metrial gland; odd-skipped-related1; spiral artery remodeling
المشرفين على المادة: 0 (Prion Proteins)
0 (Prions)
EC 2.7.11.1 (Oxsr1 protein, rat)
تواريخ الأحداث: Date Created: 20231011 Date Completed: 20231218 Latest Revision: 20240201
رمز التحديث: 20240201
DOI: 10.1002/jcp.31130
PMID: 37819170
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-4652
DOI:10.1002/jcp.31130