دورية أكاديمية
The role of intestinal microbiota on pre-eclampsia: Systematic review and meta-analysis.
| العنوان: | The role of intestinal microbiota on pre-eclampsia: Systematic review and meta-analysis. |
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| المؤلفون: | Colonetti T; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil. Electronic address: tamycolonetti@unesc.net., Limas Carmo Teixeira D; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Grande AJ; Laboratory of Evidence-based Health, Universidade Estadual de Mato Grosso do Sul, Campo Grande, MS, Brazil., Rodrigues Uggioni ML; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Generoso J; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil. Electronic address: jsg@unesc.net., Harding S; Department of Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, SE1 9NH London, UK., Rodriguez-Mateos A; Department of Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, SE1 9NH London, UK., Rech P; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Rosa Silva F; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Toreti I; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Ceretta L; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Rosa MI; Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil. |
| المصدر: | European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2023 Dec; Vol. 291, pp. 49-58. Date of Electronic Publication: 2023 Oct 02. |
| نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 0375672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7654 (Electronic) Linking ISSN: 03012115 NLM ISO Abbreviation: Eur J Obstet Gynecol Reprod Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Scientific Publishers Original Publication: Amsterdam, Excerpta Medica. |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome* , Pre-Eclampsia*, Pregnancy ; Humans ; Female ; Observational Studies as Topic |
| مستخلص: | Aim: To investigate differences between gut microbiota diversity and composition of healthy pregnant women and women with pre-eclampsia (PE). Methods and Results: This is a systematic review and meta-analysis of the literature, in which the terms "pre-eclampsia", "gastrointestinal microbiome" and "pregnant women" were used to search MEDLINE (PubMed), BVS (LILACS and others), Embase (Elsevier) and Cochrane Library, including observational studies and case-control that investigated changes in the gut microbiota during pregnancy. Six studies were included, with 479 pregnant women. A significantly lower gut microbiota alpha diversity measured as the Shannon index was found in pregnant women with PE in comparison with healthy controls (SMD: -0.47; 95 %IC: -0.77 to -0.18; P = 0.02; I 2 = 0 %; three studies, 179 participants), while no significant differences were found in the relative abundance of Bacteroidetes, Firmicutes, Actinobacteria, and Proteobacteria, despite significant differences reported in the individual studies. Conclusion: Pregnant women with PE have lower gut microbiome diversity, however, there is insufficient evidence to determine whether there are changes in gut microbiota composition. Significance and Impact of the Study: The gut microbiota can be a new treatment target to try to prevent changes in maternal bacterial proportions, aiming to reduce complications during pregnancy. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Gastrointestinal microbiome; Microbiota; Pre-eclampsia; Pregnant women; Systematic review |
| تواريخ الأحداث: | Date Created: 20231012 Date Completed: 20231124 Latest Revision: 20231124 |
| رمز التحديث: | 20231124 |
| DOI: | 10.1016/j.ejogrb.2023.10.003 |
| PMID: | 37826991 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-7654 |
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| DOI: | 10.1016/j.ejogrb.2023.10.003 |