Evaluation of the biological responses of silver nanoparticles synthesized using Pelargonium x hortorum extract.

التفاصيل البيبلوغرافية
العنوان:	Evaluation of the biological responses of silver nanoparticles synthesized using Pelargonium x hortorum extract.
المؤلفون:	Lopez-Ayuso CA; Programa de Doctorado en Ciencias Odontológicas, Universidad Nacional Autónoma de México (UNAM) Mexico.; Interdisciplinary Research Laboratory (LII), Nanostructures and Biomaterials Area, Escuela Nacional de Estudios Superiores (ENES) Unidad León, Universidad Nacional Autónoma de México Predio el Saucillo y el Potrero, Comunidad de los Tepetates 37684 León Mexico lacosta@enes.unam.mx., Garcia-Contreras R; Interdisciplinary Research Laboratory (LII), Nanostructures and Biomaterials Area, Escuela Nacional de Estudios Superiores (ENES) Unidad León, Universidad Nacional Autónoma de México Predio el Saucillo y el Potrero, Comunidad de los Tepetates 37684 León Mexico lacosta@enes.unam.mx., Manisekaran R; Interdisciplinary Research Laboratory (LII), Nanostructures and Biomaterials Area, Escuela Nacional de Estudios Superiores (ENES) Unidad León, Universidad Nacional Autónoma de México Predio el Saucillo y el Potrero, Comunidad de los Tepetates 37684 León Mexico lacosta@enes.unam.mx., Figueroa M; Facultad de Química, UNAM Ciudad de México 04510 Mexico., Arenas-Arrocena MC; Interdisciplinary Research Laboratory (LII), Nanostructures and Biomaterials Area, Escuela Nacional de Estudios Superiores (ENES) Unidad León, Universidad Nacional Autónoma de México Predio el Saucillo y el Potrero, Comunidad de los Tepetates 37684 León Mexico lacosta@enes.unam.mx., Hernandez-Padron G; Centro de Física Aplicada y Tecnología Avanzada (CFATA), Departamento de Nanotecnología, Universidad Nacional Autónoma de México Campus Juriquilla Juriquilla 76230 Mexico., Pozos-Guillén A; Basic Science Laboratory, Faculty of Stomatology, San Luis Potosí University Av. Dr. Manuel Nava #2, Zona Universitaria 78290 San Luis Potosí SLP Mexico., Acosta-Torres LS; Interdisciplinary Research Laboratory (LII), Nanostructures and Biomaterials Area, Escuela Nacional de Estudios Superiores (ENES) Unidad León, Universidad Nacional Autónoma de México Predio el Saucillo y el Potrero, Comunidad de los Tepetates 37684 León Mexico lacosta@enes.unam.mx.
المصدر:	RSC advances [RSC Adv] 2023 Oct 11; Vol. 13 (42), pp. 29784-29800. Date of Electronic Publication: 2023 Oct 11 (Print Publication: 2023).
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Original Publication: Cambridge [England] : Royal Society of Chemistry, [2011]-
مستخلص:	Silver nanoparticles (AgNPs) are one of the widely studied nanomaterials for diverse biomedical applications, in particular, as antimicrobial agents to kill bacteria, fungi, and viruses. In this report, AgNPs were synthesized using a geranium ( Pelargonium x hortorum ) leaves extract and tested for their antimicrobial and cytotoxic activity and reactive oxygen species (ROS) production. Using green biosynthesis, the leaves extract was employed as a reducing and stabilizing agent. Synthesis parameters like reaction time and precursor (silver nitrate AgNO 3 ) volume final were modified, and the products were tested against Streptococcus mutans . For the first time, the metabolomic analysis of extract, we have identified more than 50 metabolites. The UV-Vis analysis showed a peak ranging from 410-430 nm, and TEM confirmed their nearly spherical morphology for all NPs. The antimicrobial activity of the NPs revealed a minimum inhibitory concentration (MIC) of 10 μg mL ^-1 . Concerning cytotoxicity, a dose-time-dependent effect was observed with a 50% cellular cytotoxicity concentration (CC 50 ) of 4.51 μg mL ^-1 at 24 h. Interestingly, the cell nuclei were visualized using fluorescence microscopy, and no significant changes were observed. These results suggest that synthesized spherical AgNPs are promising potential candidates for medical applications. Competing Interests: There are no conflicts of interest to declare. (This journal is © The Royal Society of Chemistry.)
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تواريخ الأحداث:	Date Created: 20231013 Latest Revision: 20231031
رمز التحديث:	20231101
مُعرف محوري في PubMed:	PMC10565737
DOI:	10.1039/d3ra00201b
PMID:	37829709
قاعدة البيانات:	MEDLINE

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تدمد:	2046-2069
DOI:	10.1039/d3ra00201b