دورية أكاديمية
أعرض في EDS

FGFR2 genetic variants in women with breast cancer.

التفاصيل البيبلوغرافية
العنوان: FGFR2 genetic variants in women with breast cancer.
المؤلفون: Dix-Peek T; Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa., Dickens C; Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa., Augustine TN; School of Anatomical Sciences, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa., Phakathi BP; 3Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of Kwa‑Zulu Natal, Durban 4001, South Africa., Van Den Berg EJ; Department of Histopathology, National Health Laboratory Services, Chris Hani Baragwanath Hospital, Johannesburg 1864, South Africa., Joffe M; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa., Ayeni OA; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa., Cubasch H; South African Medical Research Council Common Epithelial Cancer Research Centre, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa., Nietz S; South African Medical Research Council Common Epithelial Cancer Research Centre, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa., Mathew CG; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa., Hayat M; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa., Neugut AI; Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, New York 10032, United States of America., Jacobson JS; Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians and Surgeons, New York 10032, United States of America., Ruff P; Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa., Duarte RAB; Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg 2193, South Africa.
المصدر: Molecular medicine reports [Mol Med Rep] 2023 Dec; Vol. 28 (6). Date of Electronic Publication: 2023 Oct 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Athens, Greece : D. A. Spandidos
مواضيع طبية MeSH: Breast Neoplasms*/pathology , Receptor, Fibroblast Growth Factor, Type 2*/genetics , Receptor, Fibroblast Growth Factor, Type 2*/metabolism, Female ; Humans ; Case-Control Studies ; Genetic Predisposition to Disease ; Genotype ; Polymorphism, Single Nucleotide ; Black People/genetics ; South Africa
مستخلص: Black African populations are more genetically diverse than others, but genetic variants have been studied primarily in European populations. The present study examined the association of four single nucleotide polymorphisms (SNPs) of the fibroblast growth factor receptor 2, associated with breast cancer in non‑African populations, with breast cancer in Black, southern African women. Genomic DNA was extracted from whole blood samples of 1,001 patients with breast cancer and 1,006 controls (without breast cancer), and the rs2981582, rs35054928, rs2981578, and rs11200014 polymorphisms were analyzed using allele‑specific Kompetitive allele‑specific PCR™, and the χ 2 or Fisher's exact tests were used to compare the genotype frequencies. There was no association between those SNPs and breast cancer in the studied cohort, although an association was identified between the C/C homozygote genotype for rs2981578 and invasive lobular carcinoma. These results show that genetic biomarkers of breast cancer risk in European populations are not necessarily associated with risk in sub‑Saharan African populations. African populations are more heterogenous than other populations, and the information from this population can help focus genetic risks of cancer in this understudied population.
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معلومات مُعتمدة: R01 CA192627 United States CA NCI NIH HHS; R01 CA250012 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: African; FGFR2; SNP; breast cancer; heterogenous; risk
المشرفين على المادة: EC 2.7.10.1 (FGFR2 protein, human)
EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 2)
تواريخ الأحداث: Date Created: 20231013 Date Completed: 20231128 Latest Revision: 20240330
رمز التحديث: 20240330
مُعرف محوري في PubMed: PMC10619128
DOI: 10.3892/mmr.2023.13113
PMID: 37830168
قاعدة البيانات: MEDLINE
الوصف
تدمد:1791-3004
DOI:10.3892/mmr.2023.13113