دورية أكاديمية
Tapirira guianensis is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in vivo.
| العنوان: | Tapirira guianensis is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in vivo. |
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| المؤلفون: | Oliveira AGS; Experimental Pathology Laboratory, Midwest Campus, Federal University of São João del-Rei, Divinópolis, Brazil., Rocha MA; Experimental Pathology Laboratory, Midwest Campus, Federal University of São João del-Rei, Divinópolis, Brazil., de Azevedo LS; Experimental Pathology Laboratory, Midwest Campus, Federal University of São João del-Rei, Divinópolis, Brazil., Coelho ATM; Experimental Pathology Laboratory, Midwest Campus, Federal University of São João del-Rei, Divinópolis, Brazil., Chagas RCR; Experimental Pathology Laboratory, Midwest Campus, Federal University of São João del-Rei, Divinópolis, Brazil., Santos HB; Tissue Processing Laboratory, Midwest Campus, Federal University of São João del-Rei, Divinópolis, Brazil., Thomé RG; Tissue Processing Laboratory, Midwest Campus, Federal University of São João del-Rei, Divinópolis, Brazil., Samuel P; Zurich University of Applied Sciences, Department of Life Sciences and Facility Management, Wädenswil, Switzerland., Wolfram E; Zurich University of Applied Sciences, Department of Life Sciences and Facility Management, Wädenswil, Switzerland., Kim B; Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal., Ribeiro RIMA; Experimental Pathology Laboratory, Midwest Campus, Federal University of São João del-Rei, Divinópolis, Brazil. |
| المصدر: | Planta medica [Planta Med] 2024 Jan; Vol. 90 (1), pp. 13-24. Date of Electronic Publication: 2023 Oct 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: George Thieme Country of Publication: Germany NLM ID: 0066751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0221 (Electronic) Linking ISSN: 00320943 NLM ISO Abbreviation: Planta Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart ; New York : George Thieme Original Publication: Stuttgart, Hippokrates Verlag. |
| مواضيع طبية MeSH: | Glioblastoma*/drug therapy , Plants, Medicinal*/chemistry , Antineoplastic Agents*/pharmacology, Plant Extracts/chemistry ; Angiogenesis ; Apoptosis ; Cell Line, Tumor |
| مستخلص: | Glioblastoma is the most frequent primary malignant brain tumor without effective treatment, which makes this work extremely relevant. The study of the bioactive compounds from medicinal plants plays an important role in the discovery of new drugs.This research investigated the constituents of Tapirira guianensis and its antitumor potential ( in vitro and in vivo) in glioblastoma. The T. guianensis extracts were characterized by mass spectrometry. The ethyl acetate partition (01ID) and its fractions 01ID-F2 and 01ID-F4 from T. guianensis showed potential antitumor treatment evidenced by selective cytotoxicity for GAMG with IC50 14.1 µg/mL, 83.07 µg/mL, 59.27 µg/mL and U251 with IC50 25.92 µg/mL, 37.3 µg/mL and 18.84 µg/mL. Fractions 01ID-F2 and 01ID-F4 were 10 times more selective when compared to TMZ and 01ID for the two evaluated cell lines. T. guianensis also reduced matrix metalloproteinases 2 - 01ID-F2 (21.84%), 01ID-F4 (29.6%) and 9 - 01ID-F4 (73.42%), ID-F4 (53.84%) activities, and induced apoptosis mainly through the extrinsic pathway. Furthermore, all treatments significantly reduced tumor size (01ID p < 0,01, 01ID-F2 p < 0,01 and 01ID-F4 p < 0,0001) and caused blood vessels to shrink in vivo . The present findings highlight that T. guianensis exhibits considerable antitumor potential in preclinical studies of glioblastoma. This ability may be related to the phenolic compounds and sesquiterpene derivatives identified in the extracts. This study deserves further in vivo research, followed by clinical investigation. Competing Interests: The authors declare that they have no conflicts of interest. (Thieme. All rights reserved.) |
| معلومات مُعتمدة: | PPM-00229-16; APQ-00068-18 Fundação de Amparo à Pesquisa do Estado de Minas Gerais; MCTI/FINEP/MS/SCTIE/DECIT-01/2013 Financiadora de Estudos e Projetos; Finance Code 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
| المشرفين على المادة: | 0 (Plant Extracts) 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20231013 Date Completed: 20231222 Latest Revision: 20231222 |
| رمز التحديث: | 20231222 |
| DOI: | 10.1055/a-2181-2569 |
| PMID: | 37832581 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1439-0221 |
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| DOI: | 10.1055/a-2181-2569 |