دورية أكاديمية
أعرض في EDS

The Physiological and Pathological Role of Acyl-CoA Oxidation.

التفاصيل البيبلوغرافية
العنوان: The Physiological and Pathological Role of Acyl-CoA Oxidation.
المؤلفون: Szrok-Jurga S; Department of Biochemistry, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdansk, Poland., Czumaj A; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, 80-211 Gdansk, Poland., Turyn J; Department of Biochemistry, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdansk, Poland., Hebanowska A; Department of Biochemistry, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdansk, Poland., Swierczynski J; Institue of Nursing and Medical Rescue, State University of Applied Sciences in Koszalin, 75-582 Koszalin, Poland., Sledzinski T; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, 80-211 Gdansk, Poland., Stelmanska E; Department of Biochemistry, Faculty of Medicine, Medical University of Gdansk, 80-211 Gdansk, Poland.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 03; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 03.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Acyl Coenzyme A*/metabolism , Fatty Acids*/metabolism, Humans ; Oxidation-Reduction ; Liver/metabolism ; Acetyl Coenzyme A/metabolism
مستخلص: Fatty acid metabolism, including β-oxidation (βOX), plays an important role in human physiology and pathology. βOX is an essential process in the energy metabolism of most human cells. Moreover, βOX is also the source of acetyl-CoA, the substrate for (a) ketone bodies synthesis, (b) cholesterol synthesis, (c) phase II detoxication, (d) protein acetylation, and (d) the synthesis of many other compounds, including N-acetylglutamate-an important regulator of urea synthesis. This review describes the current knowledge on the importance of the mitochondrial and peroxisomal βOX in various organs, including the liver, heart, kidney, lung, gastrointestinal tract, peripheral white blood cells, and other cells. In addition, the diseases associated with a disturbance of fatty acid oxidation (FAO) in the liver, heart, kidney, lung, alimentary tract, and other organs or cells are presented. Special attention was paid to abnormalities of FAO in cancer cells and the diseases caused by mutations in gene-encoding enzymes involved in FAO. Finally, issues related to α- and ω- fatty acid oxidation are discussed.
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معلومات مُعتمدة: ST40, ST41 Gdańsk Medical University
فهرسة مساهمة: Keywords: acyl-CoA; beta-oxidation; fatty acid metabolism; peroxisomal fatty acid oxidation
المشرفين على المادة: 0 (Acyl Coenzyme A)
0 (Fatty Acids)
72-89-9 (Acetyl Coenzyme A)
تواريخ الأحداث: Date Created: 20231014 Date Completed: 20231023 Latest Revision: 20231023
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10573383
DOI: 10.3390/ijms241914857
PMID: 37834305
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms241914857