دورية أكاديمية
Bacterial Modification of the Association Between Arsenic and Autism-Related Social Behavior Scores.
| العنوان: | Bacterial Modification of the Association Between Arsenic and Autism-Related Social Behavior Scores. |
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| المؤلفون: | Laue HE; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; One Medical Center Dr, WTRB 700, Lebanon, NH 03766, USA., Moroishi Y; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Jackson BP; Department of Earth Sciences, Dartmouth College, Hanover, NH, USA., Palys TJ; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Baker ER; Department of Obstetrics and Gynecology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Korrick SA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Madan JC; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Division of Neonatology, Department of Pediatrics, Children's Hospital at Dartmouth, Hanover, NH, USA., Karagas MR; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. |
| المصدر: | Exposure and health [Expo Health] 2023 Jun; Vol. 15 (2), pp. 347-354. Date of Electronic Publication: 2022 Jun 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Nature B.V Country of Publication: Netherlands NLM ID: 101681216 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2451-9766 (Print) Linking ISSN: 24519766 NLM ISO Abbreviation: Expo Health Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Dordrecht, Netherlands] : Springer Nature B.V., [2016]- |
| مستخلص: | Arsenic is related to neurodevelopmental outcomes and is associated with the composition of the gut microbiome. Data on the modifying role of the microbiome are limited. We probed suggestive relationships between arsenic and social behaviors to quantify the modifying role of the infant gut microbiome. We followed children for whom arsenic concentrations were quantified in 6-week-old toenail clippings. Scores on the Social Responsiveness Scale (SRS-2), which measures autism-related social behaviors, were provided by caregivers when the child was approximately 3 years of age. Metagenomic sequencing was performed on infant stools collected at 6 weeks and 1 year of age. To evaluate modification by the top ten most abundant species and functional pathways, we modeled SRS-2 total T -scores as a function of arsenic concentrations, microbiome features dichotomized at their median, and an interaction between exposure and the microbiome, adjusting for other trace elements and sociodemographic characteristics. As compared to the standardized population (SRS-2 T -scores = 50), participants in our study had lower SRS-2 scores ( n = 78, mean = 44, SD = 5).The relative abundances of several functional pathways identified in 6-week stool samples modified the arsenic-SRS-2 association, including the pathways of valine and isoleucine biosynthesis; we observed no association among those with high relative abundance of each pathway [ β = - 0.67 (95% CI - 1.46, 0.12)], and an adverse association [ β = 1.67 (95% CI 0.3, 3.04), p Competing Interests: Conflict of interest The authors have no relevant financial or non-financial interests to disclose. |
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| معلومات مُعتمدة: | UH3 OD023275 United States OD NIH HHS; P42 ES007373 United States ES NIEHS NIH HHS; P20 ES018175 United States ES NIEHS NIH HHS; P01 ES022832 United States ES NIEHS NIH HHS; UG3 OD023275 United States OD NIH HHS; P20 GM104416 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: Arsenic; Autism; Branched chain amino acids; Infant gut microbiome; Metagenomic sequencing; Social Responsiveness Scale |
| تواريخ الأحداث: | Date Created: 20231016 Latest Revision: 20240603 |
| رمز التحديث: | 20240603 |
| مُعرف محوري في PubMed: | PMC10569445 |
| DOI: | 10.1007/s12403-022-00494-0 |
| PMID: | 37840773 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2451-9766 |
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| DOI: | 10.1007/s12403-022-00494-0 |