دورية أكاديمية
أعرض في EDS

Risk Factors in Patients with Low Back Pain Under 40 Years Old: Quantitative Analysis Based on Computed Tomography and Magnetic Resonance Imaging mDIXON-Quant.

التفاصيل البيبلوغرافية
العنوان: Risk Factors in Patients with Low Back Pain Under 40 Years Old: Quantitative Analysis Based on Computed Tomography and Magnetic Resonance Imaging mDIXON-Quant.
المؤلفون: Fan Z; Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China., Wang T; Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China., Wang Y; Departments of Orthopedics, The 4th People's Hospital of Shenyang, Liaoning, Shenyang, Liaoning, People's Republic of China., Zhou Z; Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China., Wu T; Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China., Liu D; Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
المصدر: Journal of pain research [J Pain Res] 2023 Oct 09; Vol. 16, pp. 3417-3431. Date of Electronic Publication: 2023 Oct 09 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101540514 Publication Model: eCollection Cited Medium: Print ISSN: 1178-7090 (Print) Linking ISSN: 11787090 NLM ISO Abbreviation: J Pain Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Auckland, N.Z.] : Dove Medical Press
مستخلص: Purpose: While low back pain (LBP) constitutes a global life disorder cause, the contribution of paraspinal muscles to its pathogenicity remains elusive. We characterized the paraspinal muscles of patients with LBP using lumbar three-dimensional computed tomography (CT) and magnetic resonance imaging (MRI) mDIXON-Quant, and evaluated the risk factors combined with clinical data.
Methods: A retrospective study involving 181 patients (10-40 years) who underwent lumbar 3D-CT and MRI mDIXON from January 1, 2021 to December 31, 2022, and divided into normal, non-chronic LBP [non-CLBP], and CLBP groups. Clinical data, paraspinal muscle cross-sectional area, Hounsfield unit for CT values, and fat fraction derived from mDIXON-Quant were compared. Three readers analyzed the images independently; intra- and interobserver agreement was measured. Spearman analysis and multiple logistic regression were used to analyze the correlation between clinical data, radiologic and paraspinal muscle parameters. A nomogram was constructed for individualized prediction.
Results: Correlation analysis revealed that body mass index, visual analog scale score, Pfirrmann grade, annulus fibrosus tear, lumbar lordosis (LL), and Modic changes correlated with LBP (all P<0.05). The Pfirrmann grade and annulus fibrosus tear showed positive correlation (r=0.673, 0.559), whereas LL was negatively correlated (r=-0.469). The multifidus CT values were negatively correlated with LBP at L4-5/L5-S1; the multifidus fat fraction was positively correlated at L4-5/L5-S1 (r=0.734, r=0.584, P<0.001). The multiple logistic regression showed that L4-5 multifidus fat fraction (P=0.046, OR=1.167), Pfirrmann grade (P=0.017, OR=0.063), LL (P=0.002, OR=0.828) and annulus fibrosus tear (P=0.005, OR=0.024) were risk factors for predicting LBP in the non-CLBP group; in the CLBP group, BMI (P=0.048 OR=1.225), L4-5 multifidus fat fraction (P=0.001 OR=1.299), LL (P=0.003, OR=0.841) and Pfirrmann classification (P=0.009, OR=0.046) were risk factors.
Conclusion: BMI, L4-5 multifidus fat fraction, LL, and Pfirrmann grade are risk factors for CLBP in patients under 40; whereas annulus fibrosus tear is an independent risk factor for non-CLBP, nomograms derived from these parameters can help predict LBP and MRI mDIXON-Quant is recommended for quantitatively analyzing paraspinal muscle fat infiltration.
Competing Interests: The authors declare no competing interests in this work.
(© 2023 Fan et al.)
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فهرسة مساهمة: Keywords: Pfirrmann grade; chronic low back pain; computed tomography values; fat infiltration; mDIXON-Quant; paraspinal muscles
تواريخ الأحداث: Date Created: 20231016 Latest Revision: 20231020
رمز التحديث: 20240514
مُعرف محوري في PubMed: PMC10573373
DOI: 10.2147/JPR.S426488
PMID: 37841453
قاعدة البيانات: MEDLINE
الوصف
تدمد:1178-7090
DOI:10.2147/JPR.S426488