دورية أكاديمية
Role of ejection fraction in patients at risk for advanced heart failure: insights from the HELP-HF registry.
| العنوان: | Role of ejection fraction in patients at risk for advanced heart failure: insights from the HELP-HF registry. |
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| المؤلفون: | Pagnesi M; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Lombardi CM; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Tedino C; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Chiarito M; Humanitas Research Hospital IRCCS, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Stolfo D; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy., Baldetti L; Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Adamo M; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Calì F; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Inciardi RM; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Tomasoni D; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Loiacono F; Humanitas Research Hospital IRCCS, Milan, Italy., Maccallini M; Humanitas Research Hospital IRCCS, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Villaschi A; Humanitas Research Hospital IRCCS, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Gasparini G; Humanitas Research Hospital IRCCS, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Montella M; Humanitas Research Hospital IRCCS, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Contessi S; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy., Cocianni D; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy., Perotto M; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy., Barone G; Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Merlo M; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy., Cappelletti AM; Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sinagra G; Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy., Pini D; Humanitas Research Hospital IRCCS, Milan, Italy., Metra M; Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy. |
| المصدر: | ESC heart failure [ESC Heart Fail] 2024 Feb; Vol. 11 (1), pp. 136-146. Date of Electronic Publication: 2023 Oct 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Ltd on behalf of the European Society of Cardiology Country of Publication: England NLM ID: 101669191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2055-5822 (Electronic) Linking ISSN: 20555822 NLM ISO Abbreviation: ESC Heart Fail Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Oxford] : John Wiley & Sons Ltd on behalf of the European Society of Cardiology, [2014]- |
| مواضيع طبية MeSH: | Heart Failure*, Male ; Humans ; Infant ; Female ; Stroke Volume ; Cause of Death ; Risk Factors ; Registries |
| مستخلص: | Aims: Patients with heart failure (HF) with reduced ejection fraction (EF) (HFrEF), mildly reduced EF (HFmrEF), and preserved EF (HFpEF) may all progress to advanced HF, but the impact of EF in the advanced setting is not well established. Our aim was to assess the prognostic impact of EF in patients with at least one 'I NEED HELP' marker for advanced HF. Methods and Results: Patients with HF and at least one high-risk 'I NEED HELP' criterion from four centres were included in this analysis. Outcomes were assessed in patients with HFrEF (EF ≤ 40%), HFmrEF (EF 41-49%), and HFpEF (EF ≥ 50%) and with EF analysed as a continuous variable. The prognostic impact of medical therapy for HF in patients with EF < 50% and EF > 50% was also evaluated. All-cause death was the primary endpoint, and cardiovascular death was a secondary endpoint. Among 1149 patients enrolled [mean age 75.1 ± 11.5 years, 67.3% males, 67.6% hospitalized, median follow-up 260 days (inter-quartile range 105-390 days)], HFrEF, HFmrEF, and HFpEF were observed in 699 (60.8%), 122 (10.6%), and 328 (28.6%) patients, and 1 year mortality was 28.3%, 26.2%, and 20.1, respectively (log-rank P = 0.036). As compared with HFrEF patients, HFpEF patients had a lower risk of all-cause death [adjusted hazard ratio (HR Conclusions: Among patients with HF and at least one 'I NEED HELP' marker for advanced HF, left ventricular EF is still of prognostic value. (© 2023 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.) |
| References: | ESC Heart Fail. 2019 Jun;6(3):475-486. (PMID: 30829002) Eur J Heart Fail. 2022 Sep;24(9):1493-1503. (PMID: 35603658) Eur Heart J. 2012 Jul;33(14):1750-7. (PMID: 21821849) Lancet. 2022 Dec 3;400(10367):1938-1952. (PMID: 36356631) JACC Heart Fail. 2021 Oct;9(10):722-732. (PMID: 34391736) J Card Fail. 2016 Jul;22(7):569-77. (PMID: 26975942) J Heart Lung Transplant. 2017 May;36(5):593-594. (PMID: 28258792) Circulation. 2021 Oct 12;144(15):e238-e250. (PMID: 34503343) Eur J Heart Fail. 2022 Feb;24(2):335-350. (PMID: 34962044) J Am Coll Cardiol. 2007 Aug 21;50(8):768-77. (PMID: 17707182) Circulation. 2008 Sep 30;118(14):1433-41. (PMID: 18794390) Eur Heart J. 2018 May 21;39(20):1770-1780. (PMID: 29390051) J Am Coll Cardiol. 2023 Jun 6;81(22):2131-2144. (PMID: 37257948) ESC Heart Fail. 2022 Jun;9(3):1507-1523. (PMID: 35352499) Eur J Heart Fail. 2022 Jan;24(1):4-131. (PMID: 35083827) Nat Rev Cardiol. 2022 Feb;19(2):100-116. (PMID: 34489589) J Card Fail. 2015 Jun;21(6):519-34. (PMID: 25953697) JACC Heart Fail. 2016 Oct;4(10):808-815. (PMID: 27395350) Circulation. 2022 May 3;145(18):e895-e1032. (PMID: 35363499) ESC Heart Fail. 2022 Oct;9(5):3643-3648. (PMID: 35757964) J Am Coll Cardiol. 2017 Nov 14;70(20):2476-2486. (PMID: 29141781) Eur J Heart Fail. 2018 Apr;20(4):738-747. (PMID: 29251818) JACC Heart Fail. 2020 Jul;8(7):523-536. (PMID: 32535126) Eur J Heart Fail. 2016 Jun;18(6):613-25. (PMID: 27324686) ESC Heart Fail. 2024 Feb;11(1):136-146. (PMID: 37845829) Eur J Heart Fail. 2017 Dec;19(12):1574-1585. (PMID: 28386917) Eur J Heart Fail. 2018 Nov;20(11):1505-1535. (PMID: 29806100) N Engl J Med. 2006 Jul 20;355(3):260-9. (PMID: 16855266) JAMA. 2006 Nov 8;296(18):2209-16. (PMID: 17090767) Curr Heart Fail Rep. 2020 Feb;17(1):1-8. (PMID: 31925667) Circ Heart Fail. 2022 May;15(5):e009218. (PMID: 35332793) J Heart Lung Transplant. 2023 Jul;42(7):e1-e222. (PMID: 37245143) Circulation. 2007 Mar 27;115(12):1563-70. (PMID: 17353436) Heart Fail Clin. 2021 Oct;17(4):533-545. (PMID: 34511203) |
| فهرسة مساهمة: | Keywords: Advanced heart failure; Ejection fraction; HFmrEF; HFpEF; HFrEF; Heart failure |
| تواريخ الأحداث: | Date Created: 20231017 Date Completed: 20240124 Latest Revision: 20240125 |
| رمز التحديث: | 20240125 |
| مُعرف محوري في PubMed: | PMC10804181 |
| DOI: | 10.1002/ehf2.14539 |
| PMID: | 37845829 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2055-5822 |
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| DOI: | 10.1002/ehf2.14539 |