دورية أكاديمية
Tamoxifen induces eryptosis through calcium accumulation and oxidative stress.
| العنوان: | Tamoxifen induces eryptosis through calcium accumulation and oxidative stress. |
|---|---|
| المؤلفون: | Alfhili MA; Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, 12372, Riyadh, Saudi Arabia. malfeehily@ksu.edu.sa., Alyousef AM; Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, 12372, Riyadh, Saudi Arabia., Alsughayyir J; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, 12372, Riyadh, Saudi Arabia. |
| المصدر: | Medical oncology (Northwood, London, England) [Med Oncol] 2023 Oct 17; Vol. 40 (11), pp. 333. Date of Electronic Publication: 2023 Oct 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : New York : Springer Original Publication: Northwood, Middlesex, England : Science and Technology Letters, c1994- |
| مواضيع طبية MeSH: | Tamoxifen*/adverse effects , Eryptosis*, Humans ; Calcium/metabolism ; Fluorescein-5-isothiocyanate/metabolism ; Fluorescein-5-isothiocyanate/pharmacology ; Oxidative Stress ; Erythrocytes ; Hemolysis ; Ascorbic Acid/pharmacology ; Ascorbic Acid/metabolism ; Urea/metabolism ; Urea/pharmacology ; Reactive Oxygen Species/metabolism |
| مستخلص: | Chemotherapy-related anemia is a major obstacle in anticancer therapy. Tamoxifen (TAM) is an antiestrogen prescribed for breast cancer patients with hemolytic potential and apoptotic properties in nucleated cells. However, the eryptotic activity of TAM has hitherto escaped the efforts of investigators. RBCs from apparently healthy volunteers were treated with 1-50 μM of TAM for 24 h at 37 °C. Hemoglobin leakage and LDH, AST, and AChE activities were photometrically determined while K + , Na + , and Mg 2+ were detected by ion-selective electrode. Flow cytometry was used to identify eryptotic cells by annexin-V-FITC, intracellular Ca 2+ by Fluo4/AM, sell size and morphology by FSC and SSC signals, respectively, and oxidative stress by H (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| References: | Suwalsky M, Hernandez P, Villena F, Aguilar F, Sotomayor CP. Interaction of the anticancer drug tamoxifen with the human erythrocyte membrane and molecular models. Z Naturforsch C J Biosci. 1998;53:182–90. (PMID: 10.1515/znc-1998-3-4079618934) Cruz Silva MM, Madeira VM, Almeida LM, Custodio JB. Hemolysis of human erythrocytes induced by tamoxifen is related to disruption of membrane structure. Biochim Biophys Acta. 2000;1464:49–61. (PMID: 10.1016/S0005-2736(99)00237-010704919) Pretorius E, du Plooy JN, Bester J. A comprehensive review on eryptosis. Cell Physiol Biochem. 2016;39:1977–2000. (PMID: 10.1159/00044789527771701) Alfhili MA, Alsughayyir J. Metabolic exhaustion and casein kinase 1alpha drive deguelin-induced premature red blood cell death. Xenobiotica. 2023;53:445–53. (PMID: 10.1080/00498254.2023.224849237590011) Alfhili MA, Lee MH. Flow cytofluorometric analysis of molecular mechanisms of premature red blood cell death. Methods Mol Biol. 2021;2326:155–65. (PMID: 10.1007/978-1-0716-1514-0_1134097267) Saebo IP, Bjoras M, Franzyk H, Helgesen E, Booth JA. Optimization of the hemolysis assay for the assessment of cytotoxicity. Int J Mol Sci. 2023;24:2914. (PMID: 10.3390/ijms24032914367692439917735) He J, Lin J, Li J, Zhang JH, Sun XM, Zeng CM. Dual effects of Ginkgo biloba leaf extract on human red blood cells. Basic Clin Pharmacol Toxicol. 2009;104:138–44. (PMID: 10.1111/j.1742-7843.2008.00354.x19143753) Rawat A, Bhatt D, Kholiya S, Chauhan A, Bawankule DU, Chanotiya CS, et al. Comparative chemical composition and acetylcholinesterase (AChE) inhibitory potential of Cinnamomum camphora and Cinnamomum tamala. Chem Biodivers. 2023;20: e202300666. (PMID: 10.1002/cbdv.20230066637533252) Jemaa M, Fezai M, Bissinger R, Lang F. Methods employed in cytofluorometric assessment of eryptosis, the suicidal erythrocyte death. Cell Physiol Biochem. 2017;43:431–44. (PMID: 10.1159/00048046928922657) Rouhimoghadam M, Safarian S, Carroll JS, Sheibani N, Bidkhori G. Tamoxifen-induced apoptosis of MCF-7 cells via GPR30/PI3K/MAPKs interactions: verification by ODE modeling and RNA sequencing. Front Physiol. 2018;9:907. (PMID: 10.3389/fphys.2018.00907300504696050429) Lang E, Bissinger R, Qadri SM, Lang F. Suicidal death of erythrocytes in cancer and its chemotherapy: a potential target in the treatment of tumor-associated anemia. Int J Cancer. 2017;141:1522–8. (PMID: 10.1002/ijc.3080028542880) Mannucci PM, Bettega D, Chantarangkul V, Tripodi A, Sacchini V, Veronesi U. Effect of tamoxifen on measurements of hemostasis in healthy women. Arch Intern Med. 1996;156:1806–10. (PMID: 10.1001/archinte.1996.004401500560068790074) Kato GJ, Steinberg MH, Gladwin MT. Intravascular hemolysis and the pathophysiology of sickle cell disease. J Clin Investig. 2017;127:750–60. (PMID: 10.1172/JCI89741282482015330745) Alfhili MA, Alsalmi E, Aljedai A, Alsughayyir J, Abudawood M, Basudan AM. Calcium-oxidative stress signaling axis and casein kinase 1alpha mediate eryptosis and hemolysis elicited by novel p53 agonist inauhzin. J Chemother. 2022;34:247–57. (PMID: 10.1080/1120009X.2021.196361634410893) Ortiz J, Teruel JA, Aranda FJ, Ortiz A. On the mechanism of membrane permeabilization by tamoxifen and 4-hydroxytamoxifen. Membranes (Basel). 2023;13:292. (PMID: 10.3390/membranes1303029236984678) Lang PA, Huober J, Bachmann C, Kempe DS, Sobiesiak M, Akel A, et al. Stimulation of erythrocyte phosphatidylserine exposure by paclitaxel. Cell Physiol Biochem. 2006;18:151–64. (PMID: 10.1159/00009519016914900) Mahmud H, Foller M, Lang F. Suicidal erythrocyte death triggered by cisplatin. Toxicology. 2008;249:40–4. (PMID: 10.1016/j.tox.2008.04.00318499324) Brun JF, Varlet-Marie E, Myzia J, Raynaud de Mauverger E, Pretorius E. Metabolic influences modulating erythrocyte deformability and eryptosis. Metabolites. 2021;12:4. (PMID: 10.3390/metabo12010004350501268778269) Lagadec C, Adriaenssens E, Toillon RA, Chopin V, Romon R, Van Coppenolle F, et al. Tamoxifen and TRAIL synergistically induce apoptosis in breast cancer cells. Oncogene. 2008;27:1472–7. (PMID: 10.1038/sj.onc.121074917767197) Liu CY, Hung MH, Wang DS, Chu PY, Su JC, Teng TH, et al. Tamoxifen induces apoptosis through cancerous inhibitor of protein phosphatase 2A-dependent phospho-Akt inactivation in estrogen receptor-negative human breast cancer cells. Breast Cancer Res. 2014;16:431. (PMID: 10.1186/s13058-014-0431-9252282804303112) Li W, Shi X, Xu Y, Wan J, Wei S, Zhu R. Tamoxifen promotes apoptosis and inhibits invasion in estrogen-positive breast cancer MCF-7 cells. Mol Med Rep. 2017;16:478–84. (PMID: 10.3892/mmr.2017.660328534964) Gupta S, Belle VS, Kumbarakeri Rajashekhar R, Jogi S, Prabhu RK. Correlation of red blood cell acetylcholinesterase enzyme activity with various RBC indices. Indian J Clin Biochem. 2018;33:445–9. (PMID: 10.1007/s12291-017-0691-030319191) Saldanha C. Human erythrocyte acetylcholinesterase in health and disease. Molecules. 2017;22:1499. (PMID: 10.3390/molecules22091499288855886151671) Pan X, Giustarini D, Lang F, Rossi R, Wieder T, Koberle M, et al. Desipramine induces eryptosis in human erythrocytes, an effect blunted by nitric oxide donor sodium nitroprusside and N-acetyl-L-cysteine but enhanced by calcium depletion. Cell Cycle. 2023. https://doi.org/10.1080/15384101.2023.2234177 . (PMID: 10.1080/15384101.2023.22341773760383110599211) Oscarson DW, Van Scoyoc GE, Ahlrichs JL. Effect of poly-2-vinylpyridine-N-oxide and sucrose on silicate-induced hemolysis of erythrocytes. J Pharm Sci. 1981;70:657–9. (PMID: 10.1002/jps.26007006206265621) Kameneva MV, Repko BM, Krasik EF, Perricelli BC, Borovetz HS. Polyethylene glycol additives reduce hemolysis in red blood cell suspensions exposed to mechanical stress. ASAIO J. 2003;49:537–42. (PMID: 10.1097/01.MAT.0000084176.30221.CF14524560) Lang KS, Myssina S, Lang PA, Tanneur V, Kempe DS, Mack AF, et al. Inhibition of erythrocyte phosphatidylserine exposure by urea and Cl. Am J Physiol Renal Physiol. 2004;286:F1046–53. (PMID: 10.1152/ajprenal.00263.200315130896) Umemoto A, Monden Y, Lin CX, Abdul-Momen M, Ueyama Y, Komaki K, et al. Determination of tamoxifen–DNA adducts in leukocytes from breast cancer patients treated with tamoxifen. Chem Res Toxicol. 2004;17:1577–83. (PMID: 10.1021/tx049930c15606132) Gowdini E, Aleyasin SA, Ramezani N, Nafisi N, Tutuni M. DOK7 CpG hypermethylation in blood leukocytes as an epigenetic biomarker for acquired tamoxifen resistant in breast cancer. J Hum Genet. 2023;68:33–8. (PMID: 10.1038/s10038-022-01092-336372800) Johnson KE, Forward JA, Tippy MD, Ceglowski JR, El-Husayni S, Kulenthirarajan R, et al. Tamoxifen directly inhibits platelet angiogenic potential and platelet-mediated metastasis. Arterioscler Thromb Vasc Biol. 2017;37:664–74. (PMID: 10.1161/ATVBAHA.116.308791281538805364056) National Center for Biotechnology Information. “PubChem Compound Summary for CID 2733526, Tamoxifen” PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Tamoxifen . Accessed 29 Aug 2023. |
| معلومات مُعتمدة: | IFKSURC-1-4407 Deputyship for Research and Innovation, Ministry of Education, Saudi Arabia |
| فهرسة مساهمة: | Keywords: Breast cancer; Eryptosis; Hemolysis; Tamoxifen |
| المشرفين على المادة: | 094ZI81Y45 (Tamoxifen) Q662QK8M3B (polyethylene glycol 8000) SY7Q814VUP (Calcium) I223NX31W9 (Fluorescein-5-isothiocyanate) PQ6CK8PD0R (Ascorbic Acid) 8W8T17847W (Urea) 0 (Reactive Oxygen Species) |
| تواريخ الأحداث: | Date Created: 20231017 Date Completed: 20231023 Latest Revision: 20231027 |
| رمز التحديث: | 20231027 |
| DOI: | 10.1007/s12032-023-02205-4 |
| PMID: | 37848569 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1559-131X |
|---|---|
| DOI: | 10.1007/s12032-023-02205-4 |