دورية أكاديمية
Triptolide inhibits epithelial ovarian tumor growth by blocking the hedgehog/Gli pathway.
| العنوان: | Triptolide inhibits epithelial ovarian tumor growth by blocking the hedgehog/Gli pathway. |
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| المؤلفون: | Hu L; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China., Gao M; Huankui Academy of Nanchang University, Nanchang 330036, Jiangxi, P.R. China., Jiang H; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China., Zhuang L; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China., Jiang Y; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China., Xie S; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China., Zhang H; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China., Wang Q; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China., Chen Q; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, P.R. China. |
| المصدر: | Aging [Aging (Albany NY)] 2023 Oct 17; Vol. 15 (20), pp. 11131-11151. Date of Electronic Publication: 2023 Oct 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Albany, NY : Impact Journals, LLC |
| مواضيع طبية MeSH: | Hedgehog Proteins*/metabolism , Ovarian Neoplasms*/drug therapy, Humans ; Female ; Zinc Finger Protein GLI1/metabolism ; Signal Transduction/physiology ; Cell Line, Tumor |
| مستخلص: | Epithelial ovarian cancer (EOC), the most predominant subtype of ovarian cancer (OC), involves poor prognosis and exhibits high aggression. Triptolide (TPL), like other Chinese herbs, has historically played a significant role in modern medicine. The screening system based on Gli-dependent luciferase reporter activity assessed the effects of over 800 natural medicinal materials on hedgehog (Hh) signaling pathway activity and discovered that TPL had an excellent inhibitory effect on Hh signaling pathway activity. However, the significance and mechanism of TPL involvement in regulating the Hh pathway have not been well explored. Thus, this work aimed to understand better how TPL affects the Hh pathway activity, which, in turn, influences the biological behavior of EOC. Our findings observed that Smo agonist SAG-induced EOC cell proliferation, migration, and invasion were drastically reversed by TPL in a concentration-dependent pattern. Further evidence suggested that TPL promotes the degradation of Gli1 and Gli2 to inhibit the activity of the Hh signaling pathway by relying on Gli1 and Gli2 ubiquitination. Our in vivo studies also confirmed that TPL could significantly inhibit the tumor growth of EOC. Taken together, our results revealed that one of the antitumor mechanisms of TPL was the targeted inhibition of the Hh/Gli pathway. |
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| فهرسة مساهمة: | Keywords: Gli1; Gli2; hedgehog; ovarian cancer; triptolide |
| المشرفين على المادة: | 0 (Hedgehog Proteins) 19ALD1S53J (triptolide) 0 (Zinc Finger Protein GLI1) |
| تواريخ الأحداث: | Date Created: 20231018 Date Completed: 20231107 Latest Revision: 20231112 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10637820 |
| DOI: | 10.18632/aging.205110 |
| PMID: | 37851362 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-4589 |
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| DOI: | 10.18632/aging.205110 |