A decade of progress in juvenile idiopathic athritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry.

التفاصيل البيبلوغرافية
العنوان:	A decade of progress in juvenile idiopathic athritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry.
المؤلفون:	Nguyen K; University of British Columbia, Vancouver, British Columbia, Canada., Barsalou J; Université de Montréal, Montréal, Quebec, Canada., Basodan D; University of Alberta, Edmonton, Alberta, Canada., Batthish M; McMaster University, Hamilton, Ontario, Canada., Benseler SM; University of Calgary, Calgary, Alberta, Canada., Berard RA; Western University, London, Ontario, Canada., Blanchette N; Health Sciences North, Sudbury, Ontario, Canada., Boire G; Université de Sherbrooke, Sherbrooke, Quebec, Canada., Bolaria R; University of British Columbia, Vancouver, British Columbia, Canada., Bruns A; Université de Sherbrooke, Sherbrooke, Quebec, Canada., Cabral DA; University of British Columbia, Vancouver, British Columbia, Canada., Cameron B; University of Toronto, Toronto, Ontario, Canada., Campillo S; McGill University, Montreal, Quebec, Canada., Cellucci T; McMaster University, Hamilton, Ontario, Canada., Chan M; University of British Columbia, Vancouver, British Columbia, Canada., Chédeville G; McGill University, Montreal, Quebec, Canada., Chetaille AL; CHU de Québec-Université Laval, Québec, Canada., Chhabra A; University of British Columbia, Vancouver, British Columbia, Canada., Couture J; Université de Montréal, Montréal, Quebec, Canada., Dancey P; Memorial University, St. John's, Newfoundland and Labrador, Canada., De Bruycker JJ; Université de Montréal, Montréal, Quebec, Canada., Demirkaya E; Western University, London, Ontario, Canada., Dhalla M; University of Calgary, Calgary, Alberta, Canada., Duffy CM; University of Ottawa, Ottawa, Ontario, Canada., Feldman BM; University of Toronto, Toronto, Ontario, Canada., Feldman DE; Université de Montréal, Montréal, Quebec, Canada., Gerschman T; University of British Columbia, Vancouver, British Columbia, Canada., Haddad E; Université de Montréal, Montréal, Quebec, Canada., Heale L; McMaster University, Hamilton, Ontario, Canada., Herrington J; McMaster University, Hamilton, Ontario, Canada., Houghton K; University of British Columbia, Vancouver, British Columbia, Canada., Huber AM; Dalhousie University, Halifax, Nova Scotia, Canada., Human A; University of British Columbia, Vancouver, British Columbia, Canada., Johnson N; University of Calgary, Calgary, Alberta, Canada., Jurencak R; University of Ottawa, Ottawa, Ontario, Canada., Lang B; Dalhousie University, Halifax, Nova Scotia, Canada., Larché M; McMaster University, Hamilton, Ontario, Canada., Laxer RM; University of Toronto, Toronto, Ontario, Canada., LeBlanc CM; McGill University, Montreal, Quebec, Canada., Lee JJY; University of Toronto, Toronto, Ontario, Canada., Levy DM; University of Toronto, Toronto, Ontario, Canada., Lim L; University of Alberta, Edmonton, Alberta, Canada., Lim LSH; University of Manitoba, Winnipeg, Manitoba, Canada., Luca N; University of Ottawa, Ottawa, Ontario, Canada., McGrath T; University of Alberta, Edmonton, Alberta, Canada., McMillan T; University of Manitoba, Winnipeg, Manitoba, Canada., Miettunen PM; University of Calgary, Calgary, Alberta, Canada., Morishita KA; University of British Columbia, Vancouver, British Columbia, Canada., Ng HY; University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Oen K; University of Manitoba, Winnipeg, Manitoba, Canada., Park J; Western University, London, Ontario, Canada., Petty RE; University of British Columbia, Vancouver, British Columbia, Canada., Proulx-Gauthier JP; CHU de Québec-Université Laval, Québec, Canada., Ramsey S; Dalhousie University, Halifax, Nova Scotia, Canada., Roth J; University of Ottawa, Ottawa, Ontario, Canada., Rosenberg AM; University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Rozenblyum E; University of Toronto, Toronto, Ontario, Canada., Rumsey DG; University of Alberta, Edmonton, Alberta, Canada., Schmeling H; University of Calgary, Calgary, Alberta, Canada., Schneider R; University of Toronto, Toronto, Ontario, Canada., Scuccimarri R; McGill University, Montreal, Quebec, Canada., Shiff NJ; University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Silverman E; University of Toronto, Toronto, Ontario, Canada., Soon G; Health Sciences North, Sudbury, Ontario, Canada.; North York General Hospital, North York, Toronto, Ontario, Canada., Spiegel L; University of Toronto, Toronto, Ontario, Canada., Stringer E; Dalhousie University, Halifax, Nova Scotia, Canada., Tam H; University of British Columbia, Vancouver, British Columbia, Canada., Tse SM; University of Toronto, Toronto, Ontario, Canada., Tucker L; University of British Columbia, Vancouver, British Columbia, Canada., Turvey S; University of British Columbia, Vancouver, British Columbia, Canada., Twilt M; University of Calgary, Calgary, Alberta, Canada., Duffy KW; University of Ottawa, Ottawa, Ontario, Canada., Yeung RSM; University of Toronto, Toronto, Ontario, Canada., Guzman J; University of British Columbia, Vancouver, British Columbia, Canada.
مؤلفون مشاركون:	ReACCh-Out and CAPRI Registry Investigators
المصدر:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2023 Oct 18. Date of Electronic Publication: 2023 Oct 18.
Publication Model:	Ahead of Print
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Oxford University Press Country of Publication: England NLM ID: 100883501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1462-0332 (Electronic) Linking ISSN: 14620324 NLM ISO Abbreviation: Rheumatology (Oxford) Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Oxford, UK : Avenel, N.J. : Oxford University Press ; Distributed by Mercury International, c1999-
مستخلص:	Objective: To assess changes in juvenile idiopathic arthritis (JIA) treatments and outcomes in Canada, comparing a 2005-2010 and a 2017-2021 inception cohorts. Methods: Patients enrolled within three months of diagnosis in the Research in Arthritis in Canadian Children Emphasizing Outcomes (ReACCh-Out) and the Canadian Alliance of Pediatric Rheumatology Investigators Registry (CAPRI) cohorts were included. Cumulative incidences of drug starts and outcome attainment within 70 weeks of diagnosis were compared with Kaplan Meier survival analysis and multivariable Cox regression. Results: The 2005-2010 and 2017-2021 cohorts included 1128 and 721 patients, respectively. JIA category distribution and baseline clinical juvenile idiopathic arthritis disease activity (cJADAS10) scores at enrolment were comparable. By 70 weeks, 6% of patients (95% CI 5, 7) in the 2005-2010 and 26% (23, 30) in the 2017-2021 cohort had started a biologic DMARD (bDMARD), and 43% (40, 47) and 60% (56, 64) had started a conventional DMARD (cDMARD), respectively. Outcome attainment was 64% (61, 67) and 83% (80, 86) for Inactive disease (Wallace criteria), 69% (66, 72) and 84% (81, 87) for minimally active disease (cJADAS10 criteria), 57% (54, 61) and 63% (59, 68) for pain control (<1/10), and 52% (47, 56) and 54% (48, 60) for a good health-related quality of life. Conclusion: Although baseline disease characteristics were comparable in the 2005-2010 and 2017-2021 cohorts, cDMARD and bDMARD use increased with a concurrent increase in minimally active and inactive disease. Improvements in parent and patient reported outcomes were smaller than improvements in disease activity. (© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
التعليقات:	Erratum in: Rheumatology (Oxford). 2023 Dec 25;:. (PMID: 38145453)
فهرسة مساهمة:	Keywords: Juvenile arthritis; outcomes; prognosis; treatment
تواريخ الأحداث:	Date Created: 20231018 Latest Revision: 20231225
رمز التحديث:	20231225
DOI:	10.1093/rheumatology/kead560
PMID:	37851400
قاعدة البيانات:	MEDLINE

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تدمد:	1462-0332
DOI:	10.1093/rheumatology/kead560