دورية أكاديمية
أعرض في EDS

ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells.

التفاصيل البيبلوغرافية
العنوان: ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells.
المؤلفون: Lafita-Navarro MC; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Hao YH; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Jiang C; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Jang S; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Chang TC; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Brown IN; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Venkateswaran N; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Maurais E; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Stachera W; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Zhang Y; Quantitative Biomedical Research Center, Department of Population & Data Sciences, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Mundy D; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Live Cell Imaging Core Facility, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Han J; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Tran VM; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Mettlen M; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Xu L; Quantitative Biomedical Research Center, Department of Population & Data Sciences, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Woodruff JB; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Grishin NV; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Kinch L; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Mendell JT; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Buszczak M; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Conacci-Sorrell M; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: maralice.conaccisorrell@utsouthwestern.edu.
المصدر: Cell reports [Cell Rep] 2023 Oct 31; Vol. 42 (10), pp. 113280. Date of Electronic Publication: 2023 Oct 16.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Ribosomal Proteins*/metabolism , Ribosome Subunits, Small, Eukaryotic*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Transcription Factors*/genetics , Transcription Factors*/metabolism , Protein Biosynthesis*, Cell Nucleolus/metabolism ; Ribosomes/metabolism ; RNA, Ribosomal, 18S/genetics ; RNA, Ribosomal, 18S/metabolism ; Humans ; Animals ; Rats
مستخلص: Increased nucleolar size and activity correlate with aberrant ribosome biogenesis and enhanced translation in cancer cells. One of the first and rate-limiting steps in translation is the interaction of the 40S small ribosome subunit with mRNAs. Here, we report the identification of the zinc finger protein 692 (ZNF692), a MYC-induced nucleolar scaffold that coordinates the final steps in the biogenesis of the small ribosome subunit. ZNF692 forms a hub containing the exosome complex and ribosome biogenesis factors specialized in the final steps of 18S rRNA processing and 40S ribosome maturation in the granular component of the nucleolus. Highly proliferative cells are more reliant on ZNF692 than normal cells; thus, we conclude that effective production of small ribosome subunits is critical for translation efficiency in cancer cells.
Competing Interests: Declaration of interests The authors declare no competing interest.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R21 CA259771 United States CA NCI NIH HHS; R01 CA263079 United States CA NCI NIH HHS; R01 CA245548 United States CA NCI NIH HHS; R01 HL144969 United States HL NHLBI NIH HHS; P30 CA142543 United States CA NCI NIH HHS; R35 GM144043 United States GM NIGMS NIH HHS; P50 CA196516 United States CA NCI NIH HHS; R01 AG079513 United States AG NIA NIH HHS; R01 GM145744 United States GM NIGMS NIH HHS; R35 CA197311 United States CA NCI NIH HHS; UM1 HG011996 United States HG NHGRI NIH HHS; R01 DK127037 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: 40S; CP: Molecular biology; EXOSC7; EXOSC8; KRR1; MYC; ZNF692; exosome; nucleolus; rRNA; ribosome biogenesis
المشرفين على المادة: 0 (Ribosomal Proteins)
0 (RNA, Ribosomal, 18S)
0 (ZNF692 protein, human)
0 (DNA-Binding Proteins)
0 (Transcription Factors)
تواريخ الأحداث: Date Created: 20231018 Date Completed: 20231129 Latest Revision: 20231211
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10710265
DOI: 10.1016/j.celrep.2023.113280
PMID: 37851577
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2023.113280