Abnormal heart rate variability and its application in predicting treatment efficacy in patients with chronic migraine: An exploratory study.

التفاصيل البيبلوغرافية
العنوان:	Abnormal heart rate variability and its application in predicting treatment efficacy in patients with chronic migraine: An exploratory study.
المؤلفون:	Chuang CH; Research Center for Education and Mind Sciences, College of Education, National Tsing Hua University, Hsinchu, Taiwan.; Institute of Information Systems and Applications, College of Electrical Engineering and Computer Science, National Tsing Hua University, Hsinchu, Taiwan., Li JY; Research Center for Education and Mind Sciences, College of Education, National Tsing Hua University, Hsinchu, Taiwan.; Department of Computer Science and Engineering, National Taiwan Ocean University, Keelung, Taiwan., King JT; College of Hua-Shih College of Education, National Dong Hwa University, Hualien, Taiwan., Chen WT; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Keelung Hospital, Ministry of Health and Welfare, Keelung, Taiwan., Chen SP; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Wang YF; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Liu HY; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Hsiao FJ; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Pan LH; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Wang SJ; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lai KL; Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.; College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
المصدر:	Cephalalgia : an international journal of headache [Cephalalgia] 2023 Oct; Vol. 43 (10), pp. 3331024231206781.
نوع المنشور:	Controlled Clinical Trial; Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Country of Publication: England NLM ID: 8200710 Publication Model: Print Cited Medium: Internet ISSN: 1468-2982 (Electronic) Linking ISSN: 03331024 NLM ISO Abbreviation: Cephalalgia Subsets: MEDLINE
أسماء مطبوعة:	Publication: Jan. 2010- : London : Sage Original Publication: Oslo : Universitetsforlaget.
مواضيع طبية MeSH:	Flunarizine* , Migraine Disorders*/prevention & control, Humans ; Cross-Sectional Studies ; Heart Rate ; Prospective Studies ; Treatment Outcome
مستخلص:	Aim: This study aimed to investigate the extent of autonomic nervous system dysfunction in patients with chronic migraine using heart rate variability analysis. In addition, we explored the potential association between heart rate variability and treatment outcomes in patients receiving preventive treatment. Methods: In this cross-sectional and prospective study, we compared heart rate variability profiles in 81 preventive-naïve chronic migraine patients and 58 healthy controls. In addition, treatment responses of patients, who received a 12-week treatment with flunarizine, were assessed in relation to baseline heart rate variability. Results: We observed that chronic migraine patients had a reduced heart rate variability, signifying autonomic dysfunction in comparison to healthy controls. Furthermore, patients presenting normal heart rate variability, characterized by a standard deviation exceeding 30 milliseconds in normal-to-normal RR intervals, experienced a superior response to flunarizine treatment. This improvement was exemplified by a significantly larger reduction in monthly headache days for patients with higher heart rate variability compared to those with lower heart rate variability: -9.7 (5.9) vs. -6.2 (6.0) days ( p = .026). Conclusions: Autonomic dysfunction occurs in chronic migraine as evaluated by heart rate variability. A preserved function is associated with a better treatment outcome to flunarizine. Trial registration: Neurologic Signatures of Chronic Pain Disorders, NCT02747940. Registered 22 April 2016, https://clinicaltrials.gov/ct2/show/NCT02747940. Competing Interests: Declaration of conflicting interestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: CH Chuang, KL Lai, JY Li, JT King, WT Chen, SP Chen, YF Wang, HY Liu, FJ Hsiao, and LLH Pan have no conflict of interest to declare. Dr. SJ Wang is the PI of clinical trials for Novartis, Lundbeck, Teva, and AbbVie. Dr. SJ Wang has received personal fees as an advisor or speaker from AbbVie, Pfizer, Orient EuroPharma, and Percept.
فهرسة مساهمة:	Keywords: Chronic migraine; electrocardiogram; flunarizine; heart rate variability; monthly headache days
سلسلة جزيئية:	ClinicalTrials.gov NCT02747940
المشرفين على المادة:	R7PLA2DM0J (Flunarizine)
تواريخ الأحداث:	Date Created: 20231018 Date Completed: 20231023 Latest Revision: 20231030
رمز التحديث:	20240628
DOI:	10.1177/03331024231206781
PMID:	37851663
قاعدة البيانات:	MEDLINE

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تدمد:	1468-2982
DOI:	10.1177/03331024231206781