دورية أكاديمية
Intestinal Ultrasound and MRI for Monitoring Therapeutic Response in Luminal Crohn's Disease: A Systematic Review.
| العنوان: | Intestinal Ultrasound and MRI for Monitoring Therapeutic Response in Luminal Crohn's Disease: A Systematic Review. |
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| المؤلفون: | Lovett GC; Department of Gastroenterology, St. Vincent's Hospital Melbourne, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia. Electronic address: grace.lovett@svha.org.au., Schulberg JD; Department of Gastroenterology, St. Vincent's Hospital Melbourne, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia., Hamilton AL; Department of Gastroenterology, St. Vincent's Hospital Melbourne, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia., Wilding HE; Library Service, St. Vincent's Hospital Melbourne, Melbourne, Australia., Kamm MA; Professor of Gastroenterology, Department of Medicine, University of Melbourne, Melbourne, Australia., Wright EK; Associate Professor of Gastroenterology, Department of Medicine, University of Melbourne, Melbourne, Australia. |
| المصدر: | Journal of the American College of Radiology : JACR [J Am Coll Radiol] 2024 Mar; Vol. 21 (3), pp. 441-463. Date of Electronic Publication: 2023 Oct 17. |
| نوع المنشور: | Systematic Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101190326 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-349X (Electronic) Linking ISSN: 15461440 NLM ISO Abbreviation: J Am Coll Radiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier, c2004- |
| مواضيع طبية MeSH: | Crohn Disease*/diagnostic imaging , Crohn Disease*/drug therapy, Humans ; Magnetic Resonance Imaging ; Endoscopy, Gastrointestinal/methods ; ROC Curve |
| مستخلص: | Purpose: Cross-sectional imaging facilitates the assessment of transmural healing in patients with Crohn's disease. This systematic review addresses the utility of MRI and intestinal ultrasound (IUS) in the assessment of disease activity in response to drug therapy compared with endoscopy in patients with luminal Crohn's disease. Methods: Database searches were undertaken using predefined terms. Studies with ≥10 patients with luminal Crohn's disease with paired endoscopy and imaging (MRI or IUS) after treatment initiation were included. Publications were identified through searches of six bibliographic databases, all run on June 24, 2022. Records were screened on title and abstract, then full text, by two independent reviewers. Results: In total, 5,760 records were identified, with 24 studies meeting the inclusion criteria. Ten studies examined IUS and found good correlation between IUS and endoscopic remission (κ = 0.63-0.73). Early reduction in bowel wall thickness at 4 to 8 weeks predicted endoscopic response at 12 to 38 weeks (area under the receiver operating characteristic curve [AUROC], 0.77; odds ratio, 10.8; P = .01). Twelve studies examined MRI, with the Magnetic Resonance Index of Activity score having high accuracy for predicting endoscopic remission (AUROC, 0.97; sensitivity, 93%; specificity, 77%). A Simplified Magnetic Resonance Index of Activity score cutoff of ≥1 identifies active endoscopic disease (AUROC, 0.92; 95% confidence interval, 0.88-0.95; P < .0001). Conclusions: IUS and MRI are both reliable, noninvasive modalities for assessing transmural healing in patients with Crohn's disease and are accurate in monitoring the response to drug therapy. These modalities can be used to monitor response to biologic induction therapy, with early changes predictive of response to treatment. (Copyright © 2023 American College of Radiology. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Crohn’s disease; Intestinal ultrasound; magnetic resonance imaging; monitoring |
| تواريخ الأحداث: | Date Created: 20231018 Date Completed: 20240304 Latest Revision: 20240304 |
| رمز التحديث: | 20240304 |
| DOI: | 10.1016/j.jacr.2023.09.010 |
| PMID: | 37852561 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1558-349X |
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| DOI: | 10.1016/j.jacr.2023.09.010 |