دورية أكاديمية
أعرض في EDS

Intravenous iron supplementation improves energy metabolism of exercising skeletal muscles without effect on either oxidative stress or inflammation in male patients with heart failure with reduced ejection fraction.

التفاصيل البيبلوغرافية
العنوان: Intravenous iron supplementation improves energy metabolism of exercising skeletal muscles without effect on either oxidative stress or inflammation in male patients with heart failure with reduced ejection fraction.
المؤلفون: Drozd MD; Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.; Institute of Heart Diseases, University Hospital, Wroclaw, Poland., Tkaczyszyn M; Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.; Institute of Heart Diseases, University Hospital, Wroclaw, Poland., Kasztura M; Department of Food Hygiene and Consumer Health Protection, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland., Węgrzynowska-Teodorczyk K; Faculty of Physiotherapy, University School of Physical Education of Wroclaw, Poland.; Cardiology Department, Center for Heart Diseases, Military Hospital, Wroclaw, Poland., Flinta I; Cardiology Department, Center for Heart Diseases, Military Hospital, Wroclaw, Poland., Banasiak W; Cardiology Department, Center for Heart Diseases, Military Hospital, Wroclaw, Poland., Ponikowski P; Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.; Institute of Heart Diseases, University Hospital, Wroclaw, Poland., Jankowska EA; Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland. evitajankowska@gmail.com.; Institute of Heart Diseases, University Hospital, Wroclaw, Poland. evitajankowska@gmail.com.
المصدر: Cardiology journal [Cardiol J] 2024; Vol. 31 (2), pp. 300-308. Date of Electronic Publication: 2023 Oct 19.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: Via Medica Country of Publication: Poland NLM ID: 101392712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1898-018X (Electronic) Linking ISSN: 1898018X NLM ISO Abbreviation: Cardiol J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Gdańsk : Via Medica
مواضيع طبية MeSH: Maltose*/*analogs & derivatives, Heart Failure*/physiopathology , Heart Failure*/drug therapy , Heart Failure*/metabolism , Energy Metabolism*/drug effects , Muscle, Skeletal*/metabolism , Stroke Volume*/drug effects , Maltose*/administration & dosage , Oxidative Stress*/drug effects , Ferric Compounds*/administration & dosage, Humans ; Male ; Middle Aged ; Double-Blind Method ; Aged ; Treatment Outcome ; Ventricular Function, Left/drug effects ; Administration, Intravenous ; Inflammation/physiopathology ; Inflammation/metabolism ; Exercise Tolerance/drug effects ; Infusions, Intravenous ; Biomarkers/blood ; Exercise/physiology
مستخلص: Background: Skeletal muscle dysfunction is a feature of heart failure (HF). Iron deficiency (ID) is prevalent in patients with HF associated with exercise intolerance and poor quality of life. Intravenous iron in iron deficient patients with HF has attenuated HF symptoms, however the pathomechanisms remain unclear. The aim of study was to assess whether intravenous iron supplementation as compared to placebo improves energy metabolism of skeletal muscles in patients with HF.
Methods: Men with heart failure with reduced ejection fraction (HFrEF) and ID were randomised in 1:1 ratio to either intravenous ferric carboxymaltose (IV FCM) or placebo. In vivo reduction of lactates by exercising skeletal muscles of forearm was analyzed. A change in lactate production between week 0 and 24 was considered as a primary endpoint of the study.
Results: There were two study arms: the placebo and the IV FCM (12 and 11 male patients with HFrEF). At baseline, there were no differences between these two study arms. IV FCM therapy as compared to placebo reduced the exertional production of lactates in exercising skeletal muscles. These effects were accompanied by a significant increase in both serum ferritin and transferrin saturation in the IV FCM arm which was not demonstrated in the placebo arm.
Conclusions: Intravenous iron supplementation in iron deficient men with HFrEF improves the functioning of skeletal muscles via an improvement in energy metabolism in exercising skeletal muscles, limiting the contribution of anaerobic reactions generating ATP as reflected by a lower in vivo lactate production in exercising muscles in patients with repleted iron stores.
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فهرسة مساهمة: Keywords: energy metabolism; exercise capacity; heart failure; iron deficiency; physical fitness; skeletal muscles
المشرفين على المادة: 69-79-4 (Maltose)
6897GXD6OE (ferric carboxymaltose)
0 (Ferric Compounds)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20231019 Date Completed: 20240430 Latest Revision: 20240531
رمز التحديث: 20240601
مُعرف محوري في PubMed: PMC11076021
DOI: 10.5603/cj.97253
PMID: 37853824
قاعدة البيانات: MEDLINE
الوصف
تدمد:1898-018X
DOI:10.5603/cj.97253