دورية أكاديمية
أعرض في EDS

Can the post-ruminal urea release impact liver metabolism, and nutritional status of beef cows at late gestation?

التفاصيل البيبلوغرافية
العنوان: Can the post-ruminal urea release impact liver metabolism, and nutritional status of beef cows at late gestation?
المؤلفون: Santos MM; Department of Animal Science, Universidade Federal de Viçosa, Viçosa, MG, Brazil.; Muscle Biology, and Nutrigenomics Laboratory, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Costa TC; Muscle Biology, and Nutrigenomics Laboratory, Universidade Federal de Viçosa, Viçosa, MG, Brazil.; Department of Animal Science, Universidade Federal de Lavras, Lavras, MG, Brazil., Mendes TAO; Department of Biochemistry, and Molecular Biology, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Dutra LL; Department of Biochemistry, and Molecular Biology, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Silva DNL; Department of Animal Science, Universidade Federal de Viçosa, Viçosa, MG, Brazil.; Muscle Biology, and Nutrigenomics Laboratory, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Araújo RD; Department of Animal Science, Universidade Federal de Viçosa, Viçosa, MG, Brazil.; Muscle Biology, and Nutrigenomics Laboratory, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Serão NVL; StatsGaze Data Science Solutions, Liverpool, NY, United States of America., Rennó LN; Department of Animal Science, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Silva YFRS; Department of Animal Science, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Detmann E; Department of Animal Science, Universidade Federal de Viçosa, Viçosa, MG, Brazil., Martín-Tereso J; Trouw Nutrition Research & Development, Amersfoort, The Netherlands., Carvalho IP; Trouw Nutrition Research & Development, Amersfoort, The Netherlands., Gionbelli MP; Department of Animal Science, Universidade Federal de Lavras, Lavras, MG, Brazil., Duarte MS; Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada.
المصدر: PloS one [PLoS One] 2023 Oct 19; Vol. 18 (10), pp. e0293216. Date of Electronic Publication: 2023 Oct 19 (Print Publication: 2023).
نوع المنشور: Journal Article; Randomized Controlled Trial, Veterinary; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Milk*/metabolism , Nutritional Status*, Animals ; Cattle ; Female ; Pregnancy ; Amino Acids/metabolism ; Animal Feed/analysis ; Diet/veterinary ; Digestion ; Fermentation ; Lactation ; Liver/metabolism ; Rumen/metabolism ; Urea/metabolism
مستخلص: We aimed to evaluate the effects of post-ruminal supply of urea (PRU) on nutritional status, and liver metabolism of pregnant beef cows during late gestation. Twenty-four Brahman dams, pregnant from a single sire, and weighing 545 kg ± 23 kg were confined into individual pens at 174 ± 23 d of gestation, and randomly assigned into one of two dietary treatments up to 270 d of gestation: Control (CON, n = 12), consisting of a basal diet supplemented with conventional urea, where the cows were fed with diets containing 13.5 g conventional urea per kg dry matter; and PRU (PRU, n = 12), consisting of a basal diet supplemented with a urea coated to extensively prevent ruminal degradation while being intestinally digestible, where the cows were fed with diets containing 14,8 g urea protected from ruminal degradation per kg dry matter. Post-ruminal supply of urea reduced the urine levels of 3-methylhistidine (P = 0.02). There were no differences between treatments for dry matter intake (DMI; P = 0.76), total digestible nutrient (TDN) intake (P = 0.30), and in the body composition variables, such as, subcutaneous fat thickness (SFT; P = 0.72), and rib eye area (REA; P = 0.85). In addition, there were no differences between treatments for serum levels of glucose (P = 0.87), and serum levels of glucogenic (P = 0.28), ketogenic (P = 0.72), glucogenic, and ketogenic (P = 0.45) amino acids, neither for urea in urine (P = 0.51) as well as urea serum (P = 0.30). One the other hand, enriched pathways were differentiated related to carbohydrate digestion, and absorption, glycolysis, pyruvate metabolism, oxidative phosphorylation, pentose phosphate pathway, and biosynthesis of amino acids of the exclusively expressed proteins in PRU cows. Shifting urea supply from the rumen to post-ruminal compartments decreases muscle catabolism in cows during late gestation. Our findings indicate that post-ruminal urea supplementation for beef cows at late gestation may improve the energy metabolism to support maternal demands. In addition, the post-ruminal urea release seems to be able to trigger pathways to counterbalance the oxidative stress associated to the increase liver metabolic rate.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Santos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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المشرفين على المادة: 0 (Amino Acids)
8W8T17847W (Urea)
تواريخ الأحداث: Date Created: 20231019 Date Completed: 20231024 Latest Revision: 20231025
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10586634
DOI: 10.1371/journal.pone.0293216
PMID: 37856443
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0293216