Neuroimaging of opioid exposure: a review of preclinical animal models to inform addiction research.

التفاصيل البيبلوغرافية
العنوان:	Neuroimaging of opioid exposure: a review of preclinical animal models to inform addiction research.
المؤلفون:	Kamens HM; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. hmk123@psu.edu., Cramer S; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA., Hanley RN; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA., Chase S; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA., Wickenheisser A; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA., Horton WJ; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA., Zhang N; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
المصدر:	Psychopharmacology [Psychopharmacology (Berl)] 2023 Dec; Vol. 240 (12), pp. 2459-2482. Date of Electronic Publication: 2023 Oct 19.
نوع المنشور:	Journal Article; Review
اللغة:	English
بيانات الدورية:	Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH:	Behavior, Addictive* , Opioid-Related Disorders*/drug therapy, Animals ; Humans ; Analgesics, Opioid/therapeutic use ; Neuroimaging/methods ; Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging
مستخلص:	Opioid use results in thousands of overdose deaths each year. To address this crisis, we need a better understanding of the neurobiological mechanisms that drive opioid abuse. The noninvasive imaging tools positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and manganese-enhanced magnetic resonance imaging (MEMRI) can be used to identify how brain activity responds to acute opioid exposure and adapts to chronic drug treatment. These techniques can be performed in humans and animal models, and brain networks identified in animals closely map to the human brain. Animal models have the advantage of being able to systematically examine the independent effects of opioid exposure in a controlled environment accounting for the complex factors that drive opioid misuse in humans. This review synthesizes literature that utilized noninvasive neuroimaging tools (PET, fMRI, and MEMRI) measuring brain activity correlates in animals to understand the neurobiological consequences of exposure to abused opioids. A PubMed search in September 2023 identified 25 publications. These manuscripts were divided into 4 categories based on the route and duration of drug exposure (acute/chronic, active/passive administration). Within each category, the results were generally consistent across drug and imaging protocols. These papers cover a 20-year range and highlight the advancements in neuroimaging methodology during that time. These advances have enabled researchers to achieve greater resolution of brain regions altered by opioid exposure and to identify patterns of brain activation across regions (i.e., functional connectivity) and within subregions of structures. After describing the existing literature, we suggest areas where additional research is needed. (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة:	Keywords: Functional magnetic resonance imaging; Imaging; Manganese-enhanced magnetic resonance imaging; Opioid; Positron emission tomography
المشرفين على المادة:	0 (Analgesics, Opioid)
تواريخ الأحداث:	Date Created: 20231019 Date Completed: 20231113 Latest Revision: 20240307
رمز التحديث:	20240308
DOI:	10.1007/s00213-023-06477-6
PMID:	37857897
قاعدة البيانات:	MEDLINE

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تدمد:	1432-2072
DOI:	10.1007/s00213-023-06477-6