دورية أكاديمية

Single-cell and spatial analyses reveal a tradeoff between murine mammary proliferation and lineage programs associated with endocrine cues.

التفاصيل البيبلوغرافية
العنوان: Single-cell and spatial analyses reveal a tradeoff between murine mammary proliferation and lineage programs associated with endocrine cues.
المؤلفون: Gray GK; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Girnius N; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; The Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Kuiken HJ; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Henstridge AZ; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Brugge JS; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: joan_brugge@hms.harvard.edu.
المصدر: Cell reports [Cell Rep] 2023 Oct 31; Vol. 42 (10), pp. 113293. Date of Electronic Publication: 2023 Oct 17.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Cues* , Mammary Glands, Animal*/metabolism, Mice ; Animals ; RNA/metabolism ; Cell Proliferation ; Spatial Analysis ; Epithelial Cells/metabolism
مستخلص: Although distinct epithelial cell types have been distinguished in glandular tissues such as the mammary gland, the extent of heterogeneity within each cell type and the degree of endocrine control of this diversity across development are incompletely understood. By combining mass cytometry and cyclic immunofluorescence, we define a rich array of murine mammary epithelial cell subtypes associated with puberty, the estrous cycle, and sex. These subtypes are differentially proliferative and spatially segregate distinctly in adult versus pubescent glands. Further, we identify systematic suppression of lineage programs at the protein and RNA levels as a common feature of mammary epithelial expansion during puberty, the estrous cycle, and gestation and uncover a pervasive enrichment of ribosomal protein genes in luminal cells elicited specifically during progesterone-dominant expansionary periods. Collectively, these data expand our knowledge of murine mammary epithelial heterogeneity and connect endocrine-driven epithelial expansion with lineage suppression.
Competing Interests: Declaration of interests J.S.B. is a member of the scientific advisory boards (SABs) of Frontier Medicines and eFFECTOR Therapeutics and was a member of the SAB of Agios Pharmaceuticals until January 2022. These roles do not constitute any conflicts of interest with this work. G.K.G. is of no relation to the Gray Foundation leadership.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: F31 CA228200 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: CP: Cancer; CP: Developmental biology; cell heterogeneity; cyclic immunofluorescence; mammary gland; mass cytometry; puberty
المشرفين على المادة: 63231-63-0 (RNA)
تواريخ الأحداث: Date Created: 20231020 Date Completed: 20231106 Latest Revision: 20240206
رمز التحديث: 20240206
مُعرف محوري في PubMed: PMC10840493
DOI: 10.1016/j.celrep.2023.113293
PMID: 37858468
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2023.113293