دورية أكاديمية
أعرض في EDS

Perceptions about and reasons for participation in research bronchoscopy in Uganda: A qualitative analysis.

التفاصيل البيبلوغرافية
العنوان: Perceptions about and reasons for participation in research bronchoscopy in Uganda: A qualitative analysis.
المؤلفون: Kaawa-Mafigiri D; School of Social Sciences, Makerere University Kampala, Kampala, Uganda.; Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda., Nsereko M; Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda., Odie M; Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda., Johnson JL; Uganda-Case Western Reserve University Research Collaboration, Kampala, Uganda.; Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States of America.
المصدر: PloS one [PLoS One] 2023 Oct 20; Vol. 18 (10), pp. e0293174. Date of Electronic Publication: 2023 Oct 20 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Bronchoscopy* , Therapeutic Misconception*, Adult ; Humans ; Uganda ; Cross-Sectional Studies ; Informed Consent ; Qualitative Research
مستخلص: This study sought to assess perceptions towards and reasons for participation in research bronchoscopy studies in a high TB burden urban setting. Additionally, the study aimed to identify areas of pre- and post-procedural concern among healthy adults approached to participate in research bronchoscopy. A cross sectional qualitative study was undertaken at the Uganda-Case Western Reserve University Collaboration Tuberculosis Research Project Clinic at Mulago National Referral Hospital in Kampala, Uganda. In-depth interviews were conducted with participants at their pre-bronchoscopy visit (n = 17) and after they had undergone bronchoscopy (n = 23) to examine their perceptions and experiences with the procedure. Following consent, all interviews were audio recorded and later transcribed and typed in MS WORD. Local language interviews were translated into English by the social science interviewers. Qualitative analysis was performed manually following an inductive and emergent approach typical in thematic analysis. This study was approved by the Makerere University School of Social Sciences Research Ethics Committee (MAKSS REC 09.18.220) and registered with the Uganda National Council for Science and Technology (UNCST SS4785). Overall willingness to participate in bronchoscopy was high as many participants viewed the study as primarily a means of getting free health checks and determining their health status. Notably, despite extensive face to face counseling for this study coupled with the fact that our participants had been involved in prior research at the site, therapeutic misconception still played a pivotal role in willingness to participate in research bronchoscopy. Therapeutic misconception has important ethical and research implications in clinical research, which requires strategies to tackle it, even among a pool of potential participants who are knowledgeable about a disease or clinical care procedures. Continuous awareness and knowledge building about the difference between being a trial participant and therapeutic misconception must become a mainstay in trials to improve the process of informed consent for future research bronchoscopy studies.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Kaawa-Mafigiri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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معلومات مُعتمدة: 75N93019C00071 United States AI NIAID NIH HHS; R01 AI124348 United States AI NIAID NIH HHS; U01 AI115642 United States AI NIAID NIH HHS
تواريخ الأحداث: Date Created: 20231020 Date Completed: 20231101 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10588838
DOI: 10.1371/journal.pone.0293174
PMID: 37862303
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0293174