دورية أكاديمية
أعرض في EDS

Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release.

التفاصيل البيبلوغرافية
العنوان: Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release.
المؤلفون: Shiota T; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Li Z; Center for Translational Biomedical Research, The University of North Carolina at Greensboro, Kannapolis, NC, USA., Chen GY; Center for Translational Biomedical Research, The University of North Carolina at Greensboro, Kannapolis, NC, USA., McKnight KL; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Shirasaki T; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Yonish B; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kim H; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Fritch EJ; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Sheahan TP; Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Muramatsu M; Department of Infectious Disease Research, Foundation for Biomedical Research and Innovation at Kobe, Kobe, Hyogo, Japan., Kapustina M; Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Cameron CE; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Li Y; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zhang Q; Center for Translational Biomedical Research, The University of North Carolina at Greensboro, Kannapolis, NC, USA.; Department of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, NC, USA., Lemon SM; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
المصدر: Science advances [Sci Adv] 2023 Oct 20; Vol. 9 (42), pp. eadj4198. Date of Electronic Publication: 2023 Oct 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]-
مواضيع طبية MeSH: Hepatovirus*/metabolism , RNA, Viral*/genetics, RNA Replication ; Virus Release ; Virus Replication/physiology ; Fatty Acids/metabolism ; Sphingolipids ; Ceramides
مستخلص: Virus-induced changes in host lipid metabolism are an important but poorly understood aspect of viral pathogenesis. By combining nontargeted lipidomics analyses of infected cells and purified extracellular quasi-enveloped virions with high-throughput RNA sequencing and genetic depletion studies, we show that hepatitis A virus, an hepatotropic picornavirus, broadly manipulates the host cell lipid environment, enhancing synthesis of ceramides and other sphingolipids and transcriptionally activating acyl-coenzyme A synthetases and fatty acid elongases to import and activate long-chain fatty acids for entry into the fatty acid elongation cycle. Phospholipids with very-long-chain acyl tails (>C22) are essential for genome replication, whereas increases in sphingolipids support assembly and release of quasi-enveloped virions wrapped in membranes highly enriched for sphingomyelin and very-long-chain ceramides. Our data provide insight into how a pathogenic virus alters lipid flux in infected hepatocytes and demonstrate a distinction between lipid species required for viral RNA synthesis versus nonlytic quasi-enveloped virus release.
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معلومات مُعتمدة: R01 DK123499 United States DK NIDDK NIH HHS; P30 CA016086 United States CA NCI NIH HHS; R01 AI150095 United States AI NIAID NIH HHS; R01 AI103083 United States AI NIAID NIH HHS; R01 AI169462 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (RNA, Viral)
0 (Fatty Acids)
0 (Sphingolipids)
0 (Ceramides)
تواريخ الأحداث: Date Created: 20231020 Date Completed: 20231102 Latest Revision: 20240216
رمز التحديث: 20240216
مُعرف محوري في PubMed: PMC10588952
DOI: 10.1126/sciadv.adj4198
PMID: 37862421
قاعدة البيانات: MEDLINE
الوصف
تدمد:2375-2548
DOI:10.1126/sciadv.adj4198