دورية أكاديمية
Plasma oxylipin profiles reflect Parkinson's disease stage.
| العنوان: | Plasma oxylipin profiles reflect Parkinson's disease stage. |
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| المؤلفون: | Chistyakov DV; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia. Electronic address: chistyakof@gmail.com., Azbukina NV; Faculty of Bioengineering and Bioinformatics, Moscow Lomonosov State University, 119234 Moscow, Russia., Lopachev AV; Laboratory of Clinical and Experimental neurochemistry, Research Center of Neurology, 125367 Moscow, Russia; Institute of Translational Biomedicine, St. Petersburg State University, 7/9 Universitetskaya Emb., St. Peters-burg 199034, Russia., Goriainov SV; Peoples' Friendship University of Russia, Moscow 117198 Russia., Astakhova AA; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia., Ptitsyna EV; Biological Department, Lomonosov Moscow State University, 119991 Moscow, Russia., Klimenko AS; Peoples' Friendship University of Russia, Moscow 117198 Russia., Poleshuk VV; Laboratory of Clinical and Experimental neurochemistry, Research Center of Neurology, 125367 Moscow, Russia., Kazanskaya RB; Laboratory of Clinical and Experimental neurochemistry, Research Center of Neurology, 125367 Moscow, Russia; Biological Department, Saint Petersburg State University, Universitetskaya Emb. 7/9, 199034 St Petersburg, Russia., Fedorova TN; Laboratory of Clinical and Experimental neurochemistry, Research Center of Neurology, 125367 Moscow, Russia., Sergeeva MG; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia. |
| المصدر: | Prostaglandins & other lipid mediators [Prostaglandins Other Lipid Mediat] 2024 Apr; Vol. 171, pp. 106788. Date of Electronic Publication: 2023 Oct 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 9808648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-8823 (Print) Linking ISSN: 10988823 NLM ISO Abbreviation: Prostaglandins Other Lipid Mediat Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Elsevier Science, c1998- |
| مواضيع طبية MeSH: | Oxylipins* , Parkinson Disease*, Humans ; Chromatography, Liquid ; Tandem Mass Spectrometry/methods ; Fatty Acids, Unsaturated/metabolism ; Arachidonic Acid |
| مستخلص: | Derivatives of polyunsaturated fatty acids (PUFAs), also known as oxylipins, are key participants in regulating inflammation. Neuroinflammation is involved in many neurodegenerative diseases, including Parkinson's disease. The development of ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) facilitated the study of oxylipins on a system level, i.e., the analysis of oxylipin profiles. We analyzed oxylipin profiles in the blood plasma of 36 healthy volunteers (HC) and 73 patients with Parkinson's disease (PD), divided into early (L\M, 29 patients) or advanced (H, 44 patients) stages based on the Hoehn and Yahr scale. Among the 40 oxylipins detected, we observed a decrease in the concentration of arachidonic acid (AA) and AA derivatives, including anandamide (AEA) and Leukotriene E4 (LTE4), and an increase in the concentration of hydroxyeicosatetraenoic acids 19-HETE and 12-HETE (PD vs HC). Correlation analysis of gender, age of PD onset, and disease stages revealed 20 compounds the concentration of which changed depending on disease stage. Comparison of the acquired oxylipin profiles to openly available PD patient brain transcriptome datasets showed that plasma oxylipins do not appear to directly reflect changes in brain metabolism at different disease stages. However, both the L\M and H stages are characterized by their own oxylipin profiles - in patients with the H stage oxylipin synthesis is increased, while in patients with L\M stages oxylipin synthesis decreases compared to HC. This suggests that different therapeutic approaches may be more effective for patients at early versus late stages of PD. Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anandamide; Blood profiling; COX; Lipidomics; Oxylipins; PUFAs; Parkinson disease; Transcriptomics; UPLC-MS/MS |
| المشرفين على المادة: | 0 (Oxylipins) 0 (Fatty Acids, Unsaturated) 27YG812J1I (Arachidonic Acid) |
| تواريخ الأحداث: | Date Created: 20231022 Date Completed: 20240311 Latest Revision: 20240311 |
| رمز التحديث: | 20240311 |
| DOI: | 10.1016/j.prostaglandins.2023.106788 |
| PMID: | 37866654 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1098-8823 |
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| DOI: | 10.1016/j.prostaglandins.2023.106788 |