دورية أكاديمية
Doxycycline vs Hydroxychloroquine + Azithromycin in the Management of COVID-19 Patients: An Open-Label Randomized Clinical Trial in Sub-Saharan Africa (DOXYCOV).
العنوان: | Doxycycline vs Hydroxychloroquine + Azithromycin in the Management of COVID-19 Patients: An Open-Label Randomized Clinical Trial in Sub-Saharan Africa (DOXYCOV). |
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المؤلفون: | Sobngwi E; Internal Medicine, Yaoundé Central Hospital, Yaoundé, CMR.; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, CMR.; Research, RSD (Research Science and Development) Institute, Yaoundé, CMR.; The Biotechnology Center, University of Yaoundé 1, Yaoundé, CMR., Zemsi S; Internal Medicine, Yaoundé Central Hospital, Yaoundé, CMR.; Research, RSD (Research Science and Development) Institute, Yaoundé, CMR., Guewo M; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, CMR.; Research, RSD (Research Science and Development) Institute, Yaoundé, CMR.; The Biotechnology Center, University of Yaoundé 1, Yaoundé, CMR., Katte JC; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaounde, CMR.; Research, RSD (Research Science and Development) Institute, Yaoundé, CMR., Kouanfack C; Internal Medicine, Yaoundé Central Hospital, Yaoundé, CMR.; Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, CMR., Mfeukeu L; Internal Medicine, Yaoundé Central Hospital, Yaoundé, CMR.; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, CMR., Zemsi A; Internal Medicine, Yaoundé Central Hospital, Yaoundé, CMR., Wasnyo Y; Internal Medicine, Yaoundé Central Hospital, Yaounde, CMR.; Research, RSD (Research Science and Development) Institute, Yaoundé, CMR., Ntsama Assiga A; Internal Medicine, Yaoundé Central Hosptial, Yaounde, CMR., Ndi Manga A; Internal Medicine, Yaoundé Central Hospital, Yaoundé, CMR.; Research and Development, RSD (Research Science and Development) Institute, Yaoundé, CMR., Sobngwi-Tambekou J; Research, RSD (Research Science and Development) Institute, Yaoundé, CMR., Ngatchou W; Hypertension Clinic, Erasme University Hospital, Brussels, BEL., Moussi Omgba C; Regional Delegation of Public Health, Ministry of Public Health, Yaoundé, CMR., Mbanya JC; Internal Medicine, Yaoundé Central Hospital, Yaounde, CMR.; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, CMR.; The Biotechnology Center, University of Yaoundé 1, Yaoundé, CMR., Ongolo Zogo P; Internal Medicine, Yaoundé Central Hospital, Yaoundé, CMR.; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, CMR.; Center for the Development of Good Practices in Health, Yaoundé Central Hospital, Yaoundé, CMR., Fouda PJ; Internal Medicine, Yaoundé Central Hospital, Yaoundé, CMR.; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, CMR. |
المصدر: | Cureus [Cureus] 2023 Sep 20; Vol. 15 (9), pp. e45619. Date of Electronic Publication: 2023 Sep 20 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Palo Alto, CA : Cureus, Inc. |
مستخلص: | Objective We aimed to compare the safety and efficacy of a doxycycline-based regimen against Cameroon National Standard Guidelines (hydroxychloroquine plus azithromycin) for the treatment of mild symptomatic COVID-19. Methods We conducted an open-label, randomized, non-inferiority trial in Cameroon comparing doxycycline 100 mg, twice daily for seven days versus hydroxychloroquine 400 mg daily for five days and azithromycin 500 mg at day 1 and 250 mg from day 2 through 5 in mild COVID-19 patients. Clinical recovery, biological parameters, and adverse events were assessed. The primary outcome was the proportion of clinical recovery on days 3, 10, and 30. Non-inferiority was determined by the clinical recovery rate between protocols with a 20-percentage points margin. Results One hundred and ninety-four participants underwent randomization and were treated either with doxycycline (n = 97) or hydroxychloroquine-azithromycin (n = 97). On day 3, 74/92 (80.4%) participants on doxycycline versus 77/95 (81.1%) on hydroxychloroquine-azithromycin-based protocols were asymptomatic (p = 0.91). On day 10, 88/92 (95.7%) participants on doxycycline versus 93/95 (97.9%) on hydroxychloroquine-azithromycin were asymptomatic (p = 0.44). On day 30, all participants were asymptomatic. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) polymerase chain reaction (PCR) test was negative on day 10 in 60/92 (65.2%) participants who were assigned to doxycycline and in 63/95 (66.3%) participants who were assigned to hydroxychloroquine-azithromycin. None of the participants were admitted for worsening of the disease after treatment initiation. Conclusion Doxycycline 100 mg twice daily for seven days proved to be safe and non-inferior in terms of efficacy when compared to hydroxychloroquine-azithromycin for preventing clinical worsening of mild symptomatic or asymptomatic COVID-19 and achieving virological suppression. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Sobngwi et al.) |
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فهرسة مساهمة: | Keywords: azithromycin; doxycycline; hydroxychloroquine; mild covid-19; sub-saharan africa |
تواريخ الأحداث: | Date Created: 20231023 Latest Revision: 20231030 |
رمز التحديث: | 20231031 |
مُعرف محوري في PubMed: | PMC10588815 |
DOI: | 10.7759/cureus.45619 |
PMID: | 37868535 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2168-8184 |
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DOI: | 10.7759/cureus.45619 |