تقرير
A challenging diagnosis of plasmablastic lymphoma: importance of integrating morpholgy immunohistochemistry and flow cytometry findings (case report).
| العنوان: | A challenging diagnosis of plasmablastic lymphoma: importance of integrating morpholgy immunohistochemistry and flow cytometry findings (case report). |
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| المؤلفون: | Kmira Z; Department of Clinical Hematology, Farhat Hached University Hospital, Sousse, 4081, Tunisia., Ahmed G; Department of Cytology, Farhat Hached University Hospital, Sousse, 4081, Tunisia., Wided C; Department of Clinical Hematology, Farhat Hached University Hospital, Sousse, 4081, Tunisia., Wided M; Department of Cytology, Farhat Hached University Hospital, Sousse, 4081, Tunisia., Zeineb N; Department of Pathology, Farhat Hached University Hospital, Sousse, 4081, Tunisia., Nihed A; Department of Pathology, Farhat Hached University Hospital, Sousse, 4081, Tunisia., Yosra BY; Department of Clinical Hematology, Farhat Hached University Hospital, Sousse, 4081, Tunisia., Regaieg H; Department of Clinical Hematology, Farhat Hached University Hospital, Sousse, 4081, Tunisia., Nejia B; Department of Cytology, Farhat Hached University Hospital, Sousse, 4081, Tunisia., Abderrahim K; Department of Clinical Hematology, Farhat Hached University Hospital, Sousse, 4081, Tunisia. |
| المصدر: | The Pan African medical journal [Pan Afr Med J] 2023 Aug 13; Vol. 45, pp. 158. Date of Electronic Publication: 2023 Aug 13 (Print Publication: 2023). |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kampala, Uganda : African Field Epidemiology Network |
| مواضيع طبية MeSH: | Plasmablastic Lymphoma*/diagnosis , Plasmablastic Lymphoma*/pathology , Multiple Myeloma*/diagnosis, Humans ; Adult ; Immunohistochemistry ; Flow Cytometry ; Prognosis |
| مستخلص: | Plasmablastic lymphoma (PBL) is a rare clinicopathological entity that still raises many diagnostic and management difficulties, particularly due to the overlap between plasmablastic lymphomas and myeloma features. We report a clinical presentation of PBL affecting bone marrow in a 43-year-old patient who was admitted for B symptoms, hepatosplenomegaly, and bicytopenia investigation. Based on these findings, acute leukemia was suspected. Bone marrow morphology immunohistochemistry and flow cytometry contributed to establishing the diagnosis of medullary PBL. The patient deteriorated and died due to septic shock. This pathology requires collaboration between clinicians, pathologists, and biologists to confirm the diagnosis early. Nevertheless, a delayed diagnosis may contribute to worsening the prognosis particularly due to advanced stage consultation. Our reported case illustrates a rare clinical presentation affecting bone marrow. In our context, a confrontation between flow cytometry and immunohistochemistry was of interest as it helped to detect the immunological features of this neoplasm. Competing Interests: The authors declare no competing interests. (Copyright: Zahra Kmira et al.) |
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| فهرسة مساهمة: | Keywords: Plasmablastic lymphoma; case report; flow cytometry; immunohistochemistry |
| تواريخ الأحداث: | Date Created: 20231023 Date Completed: 20231102 Latest Revision: 20231102 |
| رمز التحديث: | 20231102 |
| مُعرف محوري في PubMed: | PMC10589407 |
| DOI: | 10.11604/pamj.2023.45.158.39896 |
| PMID: | 37869229 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1937-8688 |
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| DOI: | 10.11604/pamj.2023.45.158.39896 |