دورية أكاديمية
أعرض في EDS

The effect of cartilage dehydration and rehydration on quantitative ultrashort echo time biomarkers.

التفاصيل البيبلوغرافية
العنوان: The effect of cartilage dehydration and rehydration on quantitative ultrashort echo time biomarkers.
المؤلفون: Wan L; Department of Radiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.; Department of Radiology, University of California, San Diego, CA, USA., Searleman AC; Department of Radiology, University of California, San Diego, CA, USA., Ma Y; Department of Radiology, University of California, San Diego, CA, USA., Wong JH; Radiology Service, VA San Diego Healthcare System, San Diego, CA, USA., Williams J; Radiology Service, VA San Diego Healthcare System, San Diego, CA, USA., Murphy ME; Orthopaedic Surgery Service, VA San Diego Healthcare System, San Diego, CA, USA., Du J; Department of Radiology, University of California, San Diego, CA, USA., Chang EY; Department of Radiology, University of California, San Diego, CA, USA.; Radiology Service, VA San Diego Healthcare System, San Diego, CA, USA., Tang G; Department of Radiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
المصدر: Quantitative imaging in medicine and surgery [Quant Imaging Med Surg] 2023 Oct 01; Vol. 13 (10), pp. 6942-6951. Date of Electronic Publication: 2023 Sep 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: AME Pub Country of Publication: China NLM ID: 101577942 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2223-4292 (Print) Linking ISSN: 22234306 NLM ISO Abbreviation: Quant Imaging Med Surg Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Hong Kong] : AME Pub.
مستخلص: Background: The effect of dehydration of ex vivo cartilage samples and rehydration with native synovial fluid or normal saline on quantitative ultrashort echo time (UTE) biomarkers are unknown. We aimed to investigate the effect of cartilage dehydration-rehydration on UTE biomarkers and to compare the rehydration capabilities of native synovial fluid and normal saline.
Methods: A total of 37 cartilage samples were harvested from patients (n=5) who underwent total knee replacement. Fresh cartilage samples were exposed to air to dehydrate for 2 hours after baseline magnetic resonance (MR) scanning, then randomly divided into two groups: one soaking in native synovial fluid (n=17) and the other in normal saline (n=20) to rehydrate for 4 hours. UTE-based biomarkers [T 1 , adiabatic T 1r (AdiabT 1r ), macromolecular fraction (MMF), magnetization transfer ratio (MTR), and T 2 *] and sample weights were evaluated for fresh, dehydrated, and rehydrated cartilage samples. Differences and agreements between groups were assessed using the values of fresh cartilage samples as reference standard.
Results: Dehydrating in air for 2 hours resulted in significant weight loss (P=0.000). T 1 , AdiabT 1r , and T 2 * decreased significantly while MMF and MTR increased significantly (all P<0.02). Non-significant differences were observed in cartilage weights after rehydrating in both synovial fluid and normal saline, with P values being 0.204 and 0.769, respectively. There were no significant differences in T 1 , AdiabT 1r , MMF, and MTR after rehydrating in synovial fluid (P>0.0167, with Bonferroni correction) while T 2 * (P=0.001) still had significant differences compared with fresh samples. However, no significant differences were detected for any of the evaluated UTE biomarkers after rehydrating in normal saline (all P>0.05). No differences were detected in the agreement of UTE biomarker measurements between fresh samples and samples rehydrated with synovial fluid and normal saline.
Conclusions: Cartilage dehydration resulted in significant changes in UTE biomarkers. Rehydrating with synovial fluid or normal saline had non-significant effect on all the evaluated UTE biomarkers except T 2 * values, which still had significant differences compared with fresh samples after rehydrating with synovial fluid. No significant difference was observed in the rehydration capabilities of native synovial fluid and normal saline.
Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://qims.amegroups.com/article/view/10.21037/qims-23-359/coif). JD serves as an unpaid editorial board member of Quantitative Imaging in Medicine and Surgery. The other authors have no conflicts of interest to declare.
(2023 Quantitative Imaging in Medicine and Surgery. All rights reserved.)
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معلومات مُعتمدة: R01 AR068987 United States AR NIAMS NIH HHS; R01 AR079484 United States AR NIAMS NIH HHS; I01 CX002211 United States CX CSRD VA; R21 AR075851 United States AR NIAMS NIH HHS; R01 AR062581 United States AR NIAMS NIH HHS; I01 CX001388 United States CX CSRD VA; I01 RX002604 United States RX RRD VA; R01 AR075825 United States AR NIAMS NIH HHS; RF1 AG075717 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Cartilage; dehydration; fresh; rehydration; ultrashort echo time magnetic resonance imaging (UTE-MRI)
تواريخ الأحداث: Date Created: 20231023 Latest Revision: 20231208
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10585582
DOI: 10.21037/qims-23-359
PMID: 37869338
قاعدة البيانات: MEDLINE
الوصف
تدمد:2223-4292
DOI:10.21037/qims-23-359