دورية أكاديمية
Topical delivery of doxepin using liposome containing cream: An emerging approach in enhancing skin retention.
| العنوان: | Topical delivery of doxepin using liposome containing cream: An emerging approach in enhancing skin retention. |
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| المؤلفون: | Asl AD; School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran., Bohlooli S; Department of Pharmacology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran., Dadkhah M; Pharmaceutical Sciences Research Centre, Ardabil University of Medical Sciences, Ardabil, Iran., Shirmard LR; Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran. |
| المصدر: | Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2023 Sep; Vol. 36 (5), pp. 1497-1506. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Faculty of Pharmacy, University of Karachi Country of Publication: Pakistan NLM ID: 9426356 Publication Model: Print Cited Medium: Internet ISSN: 1011-601X (Print) Linking ISSN: 1011601X NLM ISO Abbreviation: Pak J Pharm Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Karachi : Faculty of Pharmacy, University of Karachi, [1988- |
| مواضيع طبية MeSH: | Liposomes* , Doxepin*/metabolism, Rats ; Animals ; Skin Absorption ; Skin/metabolism ; Administration, Cutaneous |
| مستخلص: | Conventional formulation of topical doxepin has similar antihistaminic effects as oral doxepin; however, its efficacy is limited due to poor localized effects on the skin. This study was designed to compare the ex vivo permeation and retention of two topical doxepin formulations; liposomal cream and plain cream. Doxepin-containing liposomes were prepared with the thin-film hydration method and assessed for size, size distribution, morphology, entrapment efficiency (EE%) and stability Using rat skin specimens in a Franz diffusion cell. Doxepin concentration in skin and receptor fluid was quantified by a validated HPLC method. The optimized liposomal formulation represented a uniform shape with narrow size distribution and an average diameter of 208.7±5.6nm. EE% of doxepin was 79±1.3 and the liposomes were stable at least for six weeks at 4 ° C. Ex vivo studies showed that while a significantly higher amount of doxepin has passed through the skin and entered the receptor compartment from conventional dosage form (47.06±2.5µg/cm2vs 11.20±0.6µg/cm2 for liposomal formulation), liposomal doxepin favoured accumulation in dermis and epidermis. These results suggest that the liposomal doxepin cream is an effective and easy-to-use formulation and may improve the cutaneous retention of doxepin, thus decreasing its systemic side effects. |
| المشرفين على المادة: | 0 (Liposomes) 1668-19-5 (Doxepin) |
| تواريخ الأحداث: | Date Created: 20231023 Date Completed: 20231102 Latest Revision: 20231102 |
| رمز التحديث: | 20231102 |
| PMID: | 37869926 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1011-601X |
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