التفاصيل البيبلوغرافية
| العنوان: |
Eastern Equine Encephalitis Virus: A Case Report and Brief Literature Review of Current Therapeutic and Preventative Strategies. |
| المؤلفون: |
Ruiz C; Department of Pharmacy, Novant Health Huntersville Medical Center, Huntersville, North Carolina, USA., Gibson G; Department of Pharmacy, St. Joseph's/Candler Health System, Savannah, Georgia, USA., Rojas S; Department of Infectious Disease, St. Joseph's/Candler Health System, Savannah, Georgia, USA., Friend K; Department of Pharmacy, St. Joseph's/Candler Health System, Savannah, Georgia, USA. |
| المصدر: |
Vector borne and zoonotic diseases (Larchmont, N.Y.) [Vector Borne Zoonotic Dis] 2024 Feb; Vol. 24 (2), pp. 118-121. Date of Electronic Publication: 2023 Oct 23. |
| نوع المنشور: |
Review; Case Reports; Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 100965525 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7759 (Electronic) Linking ISSN: 15303667 NLM ISO Abbreviation: Vector Borne Zoonotic Dis Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., [2001- |
| مواضيع طبية MeSH: |
Encephalitis Virus, Eastern Equine* , Ischemic Stroke*/veterinary , Encephalomyelitis, Equine*/veterinary, Humans ; Female ; Horses ; Animals ; Middle Aged ; Retrospective Studies ; Prospective Studies ; Anti-Bacterial Agents |
| مستخلص: |
Background: Eastern equine encephalitis virus (EEEV) is a rare mosquito-borne illness exhibiting rapid neurological deterioration and permanent damage. Despite its >30% mortality and >60% long-term neurological damage, EEEV has no approved antiviral medication or vaccination. This report uniquely aims to describe a rare case of EEEV and provide a current literature review of therapeutic and preventative options from the clinical perspective to guide clinicians and public health workers, along with informing them about its impact and current knowledge gaps. Methods: A retrospective chart review of the electronic medical record was performed for a patient's 10-day hospital admission in July 2021. In addition, PubMed was searched using relevant keywords for a literature review of EEEV. Results: A 61-year-old woman presented with dysarthria and right-sided facial droop. Acute ischemic stroke was ruled out, and empiric intravenous (IV) antibiotics were initiated for possible infectious etiology. The patient developed worsening mental status and fever and was intubated, with antibiotics broadened with concern for meningitis along with tick-borne illness. The patient remained encephalopathic and febrile, and lumbar serologies were consistent with viral meningoencephalitis or acute disseminated encephalomyelitis. Several days after collection, quantitative antibody testing returned positive for EEEV. The patient was pronounced dead on hospital day 10. On review of the literature regarding EEEV, supportive care and prevention remain the cornerstone of management. Although early IV immunoglobulin and high-dose steroids have shown potential as treatments to reduce morbidity and mortality, no vaccines have been approved to date. Conclusion: Prospective trials and further investigations into treatment and preventative options may be useful in reducing the morbidity and mortality associated with EEEV. |
| فهرسة مساهمة: |
Keywords: EEEV; IVIG; case report; steroids; vaccine |
| المشرفين على المادة: |
0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: |
Date Created: 20231023 Date Completed: 20240209 Latest Revision: 20240430 |
| رمز التحديث: |
20240501 |
| DOI: |
10.1089/vbz.2023.0011 |
| PMID: |
37870590 |
| قاعدة البيانات: |
MEDLINE |
