دورية أكاديمية
Xanthotoxol relieves itch in mice via suppressing spinal GRP/GRPR signaling.
| العنوان: | Xanthotoxol relieves itch in mice via suppressing spinal GRP/GRPR signaling. |
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| المؤلفون: | Gao X; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China., Yang Y; Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China., Zhu J; Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China., Zhang Y; Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China., Wang C; Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China., Wang Z; School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: zfwang@shutcm.edu.cn., Mi W; Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address: wenlimi@fudan.edu.cn., Du L; Department of Biochemistry, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: lixia_du@shutcm.edu.cn. |
| المصدر: | European journal of pharmacology [Eur J Pharmacol] 2023 Dec 05; Vol. 960, pp. 176147. Date of Electronic Publication: 2023 Oct 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Amsterdam : Elsevier Science Original Publication: Amsterdam, North Holland Pub. Co. |
| مواضيع طبية MeSH: | Furocoumarins*/pharmacology , Furocoumarins*/therapeutic use , Receptors, Bombesin*/metabolism, Animals ; Mice ; Gastrin-Releasing Peptide/pharmacology ; Gastrin-Releasing Peptide/physiology ; Mice, Inbred C57BL ; Pruritus/drug therapy ; Pruritus/chemically induced ; Spinal Cord |
| مستخلص: | Although pruritus, commonly known as itch, is a common and debilitating symptom associated with various skin conditions, there is a lack of effective therapies available. Xanthotoxol (XAN), a biologically active linear furocoumarin, shows potential in the treatment of various neurological disorders. In this study, we discovered that administering XAN either through intraperitoneal or intrathecal injections effectively reduced scratching behavior induced by compound 48/80 or chloroquine. Importantly, XAN also substantially alleviates chronic itch in dry skin and allergic contact dermatitis mice. Substantial progress has highlighted the crucial role of gastrin-releasing peptide (GRP)-gastrin-releasing peptide receptor (GRPR) signaling in the dorsal spinal cord in transmitting various types of itch. Our behavior tests revealed that XAN significantly alleviated scratching behaviors induced by intrathecal administration of GRP or GRPR agonist bombesin. Furthermore, XAN reduced the activation of neurons in the spinal cord caused by intrathecal administration of GRP in mice. Moreover, XAN attenuates the activation of spinal GRPR-positive neurons in itchy mice. These findings suggest that XAN mitigates itch in mice by suppressing spinal GRP/GRPR signaling, thereby establishing XAN as a promising therapeutic option for treating pruritus. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: GRP; GRPR; Itch; Spinal cord; Xanthotoxol |
| المشرفين على المادة: | 0 (Furocoumarins) 80043-53-4 (Gastrin-Releasing Peptide) 0 (Receptors, Bombesin) 2009-24-7 (xanthotoxol) |
| تواريخ الأحداث: | Date Created: 20231023 Date Completed: 20231130 Latest Revision: 20231130 |
| رمز التحديث: | 20231130 |
| DOI: | 10.1016/j.ejphar.2023.176147 |
| PMID: | 37871763 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0712 |
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| DOI: | 10.1016/j.ejphar.2023.176147 |