دورية أكاديمية
Twenty-four-hour ambulatory, but not clinic blood pressure associates with leptin in young adults with overweight or obesity: The African-PREDICT study.
| العنوان: | Twenty-four-hour ambulatory, but not clinic blood pressure associates with leptin in young adults with overweight or obesity: The African-PREDICT study. |
|---|---|
| المؤلفون: | van Niekerk E; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa., Botha-Le Roux S; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.; Medical Research Council: Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Mels CMC; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.; Medical Research Council: Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Swanepoel M; Physical activity, Sport and Recreation (PhASRec), North-West University, Potchefstroom, South Africa., Delles C; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK., Welsh P; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK., Kruger R; Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa. Ruan.Kruger@nwu.ac.za.; Medical Research Council: Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. Ruan.Kruger@nwu.ac.za. |
| المصدر: | Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2024 Feb; Vol. 47 (2), pp. 478-486. Date of Electronic Publication: 2023 Oct 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9307690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1348-4214 (Electronic) Linking ISSN: 09169636 NLM ISO Abbreviation: Hypertens Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2009- : London : Nature Publishing Group Original Publication: Toyonaka, Japan : The Society, c1992-2003 |
| مواضيع طبية MeSH: | Hypertension* , Overweight*/complications, Adult ; Female ; Humans ; Male ; Young Adult ; Blood Pressure/physiology ; Blood Pressure Monitoring, Ambulatory ; Body Mass Index ; Cross-Sectional Studies ; Leptin ; Obesity/complications |
| مستخلص: | Hypertension and obesity are known pro-inflammatory conditions, and limited studies explored various blood pressure modalities and inflammatory markers in young adults with overweight or obesity (OW/OB). We assessed the relationship of clinic and 24 h ambulatory blood pressure with an array of inflammatory markers in young adults with OW/OB. This cross-sectional study included women and men of Black and White ethnicity (n = 1194) with a median age of 24.5 ± 3.12 years. Participants were divided into normal weight and OW/OB groups according to body mass index. Clinic and 24 h ambulatory systolic and diastolic blood pressure were measured. Inflammatory markers included leptin, interleukin-6, interleukin-8, tumour necrosis factor-α, adiponectin, interleukin-10, and C-reactive protein. After adjustments for age, sex, and ethnicity, the OW/OB group had higher blood pressure and an overall worse inflammatory profile compared to the normal weight group (all p ≤ 0.024). In the OW/OB group, 24 h systolic (r = 0.22; p < 0.001) and diastolic blood pressure (r = 0.28; p < 0.001) correlated with leptin, independent of age, sex, and ethnicity. In fully adjusted regression models, 24 h systolic blood pressure (adj.R 2 = 0.25; β = 0.28; p = 0.035) and diastolic blood pressure (adj.R 2 = 0.10; β = 0.32; p = 0.034), associated with leptin in the OW/OB group and significance remained with additional adjustments for visceral adiposity index. Twenty-four-hour ambulatory, but not clinic blood pressure, is related to leptin in young adults with OW/OB. Leptin shows a stronger relationship with adiposity when compared to other inflammatory markers and may play a role in subcutaneous adiposity-related increased blood pressure. (© 2023. The Author(s).) |
| References: | Murray CJ, Aravkin AY, Zheng P, Abbafati C, Abbas KM, Abbasi-Kangevari M, et al. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396:1223–49. (PMID: 10.1016/S0140-6736(20)30752-2) Natsis M, Antza C, Doundoulakis I, Stabouli S, Kotsis V. Hypertension in obesity: novel insights. Curr Hypertens Rev. 2020;16:30–6. (PMID: 30987571) Mouton AJ, Li X, Hall ME, Hall JE. Obesity, hypertension, and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation. Circ Res. 2020;126:789–806. (PMID: 10.1161/CIRCRESAHA.119.312321321633417255054) Siedlinski M, Jozefczuk E, Xu X, Teumer A, Evangelou E, Schnabel RB, et al. White blood cells and blood pressure: a Mendelian randomization study. Circulation. 2020;141:1307–17. (PMID: 10.1161/CIRCULATIONAHA.119.045102321480837176352) Kang YS. Obesity associated hypertension: new insights into mechanism. Electrolyte Blood Press. 2013;11:46. (PMID: 10.5049/EBP.2013.11.2.46246277043950225) De Faria AP, Ritter AM, Gasparetti CS, Corrêa NB, Brunelli V, Almeida A, et al. A proposed inflammatory score of circulating cytokines/adipokines associated with resistant hypertension, but dependent on obesity parameters. Arq Bras Cardiol. 2019;112:383–9. (PMID: 308439316459424) Huang QF, Yang WY, Asayama K, Zhang ZY, Thijs L, Li Y, et al. Ambulatory blood pressure monitoring to diagnose and manage hypertension. Hypertension. 2021;77:254–64. (PMID: 10.1161/HYPERTENSIONAHA.120.1459133390042) Cepeda M, Pham P, Shimbo D. Status of ambulatory blood pressure monitoring and home blood pressure monitoring for the diagnosis and management of hypertension in the US: an up-to-date review. Hypertens Res. 2023;46:620–9. (PMID: 10.1038/s41440-022-01137-2366044759813901) Tepe D, Yılmaz S. Is Office Blood Pressure Measurement Reliable in Obese Adolescents? Diabetes Metab Syndr Obes. 2021;14:3809–17. (PMID: 10.2147/DMSO.S329273345119548421040) Schutte AE, Gona PN, Delles C, Uys AS, Burger A, Mels CM, et al. The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT): Design, recruitment and initial examination. Eur J Prev Cardiol. 2019;26:458–70. (PMID: 10.1177/2047487318822354306813776423686) Stewart A, Marfell-Jones M, Olds T, De Ridder H. International Standards For Anthropometric Assessment (ISAK). Lower Hutt: International Society for the Advancement of Kinanthropometry; 2011. Amato MC, Giordano C, Galia M, Criscimanna A, Vitabile S, Midiri M, et al. Visceral Adiposity Index: a reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes Care. 2010;33:920–2. (PMID: 10.2337/dc09-1825200679712845052) Barna I, Keszei A, Dunai A. Evaluation of Meditech ABPM-04 ambulatory blood pressure measuring device according to the British Hypertension Society protocol. Blood Press Monit. 1998;3:363–8. (PMID: 10212378) Xu JP, Zeng RX, Zhang YZ, Lin SS, Tan JW, Zhu HY, et al. Systemic inflammation markers and the prevalence of hypertension: A NHANES cross-sectional study. Hypertens Res. 2023;46:1009–19. (PMID: 10.1038/s41440-023-01195-036707716) Dessie G, Ayelign B, Akalu Y, Shibabaw T, Molla MD. Effect of leptin on chronic inflammatory disorders: insights to therapeutic target to prevent further cardiovascular complication. Diabetes Metab Syndr Obes. 2021;14:3307–22. (PMID: 10.2147/DMSO.S321311343054028296717) Thomopoulos C, Papadopoulos DP, Papazachou O, Bratsas A, Massias S, Anastasiadis G, et al. Free leptin is associated with masked hypertension in nonobese subjects: a cross-sectional study. Hypertension. 2009;53:965–72. (PMID: 10.1161/HYPERTENSIONAHA.108.12804119398660) Para I, Albu A, Porojan MD. Adipokines and arterial stiffness in obesity. Medicina. 2021;57:653. (PMID: 10.3390/medicina57070653342023238305474) Kang KW, Ok M, Lee SK. Leptin as a key between obesity and cardiovascular disease. J Obes Metab Syndr. 2020;29:248. (PMID: 10.7570/jomes20120333427677789022) Bell BB, Rahmouni K. Leptin as a mediator of obesity-induced hypertension. Curr Obes Rep. 2016;5:397–404. (PMID: 10.1007/s13679-016-0231-x276651075119542) Brown RJ, Meehan CA, Gorden P. Leptin does not mediate hypertension associated with human obesity. Cell. 2015;162:465–6. (PMID: 10.1016/j.cell.2015.07.007262322147262432) Martin-Gonzalez J, Segura-Egea JJ, Pérez-Pérez A, Cabanillas-Balsera D, Sánchez-Margalet V. Leptin in dental pulp and periapical tissues: a narrative review. Int Mol Sci. 2022;23:1984. (PMID: 10.3390/ijms23041984) Shams E, Kamalumpundi V, Peterson J, Gismondi RA, Oigman W, de Gusmão, et al. Highlights of mechanisms and treatment of obesity-related hypertension. J Hum Hypertens. 2022;36:785–93. (PMID: 10.1038/s41371-021-00644-y35001082) Von Schnurbein J, Manzoor J, Brandt S, Denzer F, Kohlsdorf K, Fischer-Posovszky P, et al. Leptin is not essential for obesity-associated hypertension. Obes Facts. 2019;12:460–75. (PMID: 10.1159/000501319) Chait A, Den Hartigh LJ. Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Front Cardiovasc Med. 2020;7:22. (PMID: 10.3389/fcvm.2020.00022321587687052117) Leite NN, Cota BC, Gotine AR, Rocha DM, Pereira PF, Hermsdorff HH. Visceral adiposity index is positively associated with blood pressure: a systematic review. Obes Res Clin Pr. 2021;15:546–56. (PMID: 10.1016/j.orcp.2021.10.001) Zamboni M, Nori N, Brunelli A, Zoico E. How does adipose tissue contribute to inflammageing? Exp Gerontol. 2021;143:111162. (PMID: 10.1016/j.exger.2020.11116233253807) Ragino YI, Stakhneva EM, Polonskaya YV, Kashtanova EV. The role of secretory activity molecules of visceral adipocytes in abdominal obesity in the development of cardiovascular disease: a review. Biomolecules. 2020;10:374. (PMID: 10.3390/biom10030374321211757175189) Van Niekerk E, Mels CMC, Swanepoel M, Delles C, Welsh P, Botha-Le Roux S. The inflammatory score and cardiovascular risk in young adults with overweight or obesity: The African-PREDICT study. Cytokine. 2023;163:156121. (PMID: 10.1016/j.cyto.2022.15612136610286) |
| فهرسة مساهمة: | Keywords: Blood pressure; Inflammation; Leptin; Obesity; Young adults |
| المشرفين على المادة: | 0 (Leptin) 0 (LEP protein, human) |
| تواريخ الأحداث: | Date Created: 20231023 Date Completed: 20240212 Latest Revision: 20240322 |
| رمز التحديث: | 20240322 |
| مُعرف محوري في PubMed: | PMC10838765 |
| DOI: | 10.1038/s41440-023-01477-7 |
| PMID: | 37872379 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1348-4214 |
|---|---|
| DOI: | 10.1038/s41440-023-01477-7 |