Oleic acid differentially affects de novo lipogenesis in adipocytes and hepatocytes.
| العنوان: | Oleic acid differentially affects de novo lipogenesis in adipocytes and hepatocytes. |
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| المؤلفون: | Castillo HB; Department of Chemistry, Yale University, New Haven, Connecticut, 06511, United States., Shuster SO; Department of Chemistry, Yale University, New Haven, Connecticut, 06511, United States., Tarekegn LH; Department of Chemistry, Yale University, New Haven, Connecticut, 06511, United States., Davis CM; Department of Chemistry, Yale University, New Haven, Connecticut, 06511, United States. |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 06. Date of Electronic Publication: 2023 Oct 06. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Lipogenesis is a vital but often dysregulated metabolic pathway. We report super-resolution multiplexed vibrational imaging of lipogenesis rates and pathways using isotopically labelled oleic acid and glucose as probes in live adipocytes and hepatocytes. These findings suggest oleic acid inhibits de novo lipogenesis (DNL), but not total lipogenesis, in hepatocytes. No significant effect is seen in adipocytes. These differential effects may be due to alternate regulation of DNL between cell types and could help explain the complicated role oleic acid plays in metabolism. Competing Interests: Conflicts of interest There are no conflicts to declare. |
| التعليقات: | Update in: Chem Commun (Camb). 2024 Feb 8;:. (PMID: 38329230) |
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| معلومات مُعتمدة: | R35 GM151146 United States GM NIGMS NIH HHS; T32 GM008283 United States GM NIGMS NIH HHS |
| تواريخ الأحداث: | Date Created: 20231024 Latest Revision: 20240314 |
| رمز التحديث: | 20240314 |
| مُعرف محوري في PubMed: | PMC10592964 |
| DOI: | 10.1101/2023.10.04.560581 |
| PMID: | 37873279 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2023.10.04.560581 |
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