دورية أكاديمية
Changes in cardiac-driven perivascular fluid movement around the MCA in a pharmacological model of acute hypertension detected with non-invasive MRI.
| العنوان: | Changes in cardiac-driven perivascular fluid movement around the MCA in a pharmacological model of acute hypertension detected with non-invasive MRI. |
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| المؤلفون: | Evans PG; UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK., Sajic M; Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, UK., Yu Y; UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK., Harrison IF; UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK., Hosford PS; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK., Smith KJ; Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, UK., Lythgoe MF; UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK., Stuckey DJ; UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK., Wells JA; UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK. |
| المصدر: | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2024 Apr; Vol. 44 (4), pp. 508-515. Date of Electronic Publication: 2023 Oct 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Thousand Oaks, CA : SAGE Publications Original Publication: New York : Raven Press, c1981- |
| مواضيع طبية MeSH: | Middle Cerebral Artery* , Hypertension*/metabolism, Rats ; Animals ; Magnetic Resonance Imaging ; Diffusion ; Brain/blood supply ; Cerebrospinal Fluid/metabolism |
| مستخلص: | Perivascular spaces mediate a complex interaction between cerebrospinal fluid and brain tissue that may be an important pathway for solute waste clearance. Their structural or functional derangement may contribute to the development of age-related neurogenerative conditions. Here, we employed a non-invasive low b - value diffusion-weighted ECG-gated MRI method to capture perivascular fluid movement around the middle cerebral artery of the anaesthetised rat brain. Using this method, we show that such MRI estimates of perivascular fluid movement directionality are highly sensitive to the cardiac cycle. We then show that these measures of fluid movement directionality are decreased in the angiotensin-II pharmacological model of acute hypertension, with an associated dampening of vessel pulsatility. This translational MRI method may, therefore, be useful to monitor derangement of perivascular fluid movement associated with cardiovascular pathologies, such as hypertension, in order to further our understanding of perivascular function in neurology. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
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| معلومات مُعتمدة: | FS/15/33/31608 United Kingdom BHF_ British Heart Foundation; MR/J013110/1 United Kingdom MRC_ Medical Research Council; FS/18/72/33942 United Kingdom BHF_ British Heart Foundation; United Kingdom WT_ Wellcome Trust; MR/R026416/1 United Kingdom MRC_ Medical Research Council; 204624/Z/16/Z United Kingdom WT_ Wellcome Trust |
| فهرسة مساهمة: | Keywords: CSF; MRI; glymphatic; hypertension; perivascular space |
| تواريخ الأحداث: | Date Created: 20231024 Date Completed: 20240328 Latest Revision: 20240401 |
| رمز التحديث: | 20240401 |
| مُعرف محوري في PubMed: | PMC10981406 |
| DOI: | 10.1177/0271678X231209641 |
| PMID: | 37873754 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1559-7016 |
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| DOI: | 10.1177/0271678X231209641 |