دورية أكاديمية
أعرض في EDS

BDNF and Lactate as Modulators of Hippocampal CA3 Network Physiology.

التفاصيل البيبلوغرافية
العنوان: BDNF and Lactate as Modulators of Hippocampal CA3 Network Physiology.
المؤلفون: Griego E; Departamento de Farmacobiología, Cinvestav Sur, Mexico City, Mexico. ernesto.griego@cinvestav.mx.; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, USA. ernesto.griego@cinvestav.mx.; Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Calzada de los Tenorios No. 235, Col. Granjas Coapa, C.P. 14330, Mexico City, Mexico. ernesto.griego@cinvestav.mx., Galván EJ; Departamento de Farmacobiología, Cinvestav Sur, Mexico City, Mexico.; Centro de Investigaciones sobre el Envejecimiento, Mexico City, Mexico.
المصدر: Cellular and molecular neurobiology [Cell Mol Neurobiol] 2023 Nov; Vol. 43 (8), pp. 4007-4022. Date of Electronic Publication: 2023 Oct 24.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8200709 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6830 (Electronic) Linking ISSN: 02724340 NLM ISO Abbreviation: Cell Mol Neurobiol Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : New York : Kluwer Academic/Plenum Publishers
Original Publication: New York : Plenum Press, c1981-
مواضيع طبية MeSH: Brain-Derived Neurotrophic Factor*/metabolism , Mossy Fibers, Hippocampal*/metabolism, Animals ; Lactic Acid/metabolism ; Hippocampus/metabolism ; Pyramidal Cells/metabolism ; Carrier Proteins/metabolism ; CA3 Region, Hippocampal/metabolism ; Mammals/metabolism
مستخلص: Growing evidence supports the notion that brain-derived neurotrophic factor (BDNF) and lactate are potent modulators of mammalian brain function. The modulatory actions of those biomolecules influence a wide range of neuronal responses, from the shaping of neuronal excitability to the induction and expression of structural and synaptic plasticity. The biological actions of BDNF and lactate are mediated by their cognate receptors and specific transporters located in the neuronal membrane. Canonical functions of BDNF occur via the tropomyosin-related kinase B receptor (TrkB), whereas lactate acts via monocarboxylate transporters or the hydroxycarboxylic acid receptor 1 (HCAR1). Both receptors are highly expressed in the central nervous system, and some of their physiological actions are particularly well characterized in the hippocampus, a brain structure involved in the neurophysiology of learning and memory. The multifarious neuronal circuitry between the axons of the dentate gyrus granule cells, mossy fibers (MF), and pyramidal neurons of area CA3 is of great interest given its role in specific mnemonic processes and involvement in a growing number of brain disorders. Whereas the modulation exerted by BDNF via TrkB has been extensively studied, the influence of lactate via HCAR1 on the properties of the MF-CA3 circuit is an emerging field. In this review, we discuss the role of both systems in the modulation of brain physiology, with emphasis on the hippocampal CA3 network. We complement this review with original data that suggest cross-modulation is exerted by these two independent neuromodulatory systems.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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معلومات مُعتمدة: 727269 Consejo Nacional de Ciencia y Tecnología; CB-2016-281617 Consejo Nacional de Ciencia y Tecnología
فهرسة مساهمة: Keywords: BNDF; CA3; HCAR1; Hippocampus; Lactate; TrkB
المشرفين على المادة: 0 (Brain-Derived Neurotrophic Factor)
33X04XA5AT (Lactic Acid)
0 (Carrier Proteins)
تواريخ الأحداث: Date Created: 20231024 Date Completed: 20231122 Latest Revision: 20231211
رمز التحديث: 20231215
DOI: 10.1007/s10571-023-01425-6
PMID: 37874456
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-6830
DOI:10.1007/s10571-023-01425-6