دورية أكاديمية
Hemophagocytic lymphohistiocytosis-how common and how severe is it as a complication of malaria? Retrospective case series and review of the literature.
العنوان: | Hemophagocytic lymphohistiocytosis-how common and how severe is it as a complication of malaria? Retrospective case series and review of the literature. |
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المؤلفون: | Orth HM; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany. hansmartin.orth@med.uni-duesseldorf.de., Wiemer D; Department of Tropical Medicine and Infectious Diseases at the Bernhard Nocht Institute, Bundeswehr Hospital Hamburg, Hamburg, Germany., Schneitler S; Institute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, Germany., Schönfeld A; Department of Infectious Diseases, West German Centre of Infectious Diseases, University Hospital Centre Essen, University of Duisburg-Essen DE, Essen, Germany., Holtfreter MC; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Gliga S; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Fuchs A; Internal Medicine III-Gastroenterology and Infectious Diseases, Augsburg University Hospital, Augsburg, Germany., Pfäfflin F; Department for Infectious Diseases and Respiratory Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany., Denkinger CM; Division of Infectious Disease and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.; German Center for Infection Research (DZIF), partner site Heidelberg University Hospital, Heidelberg, Germany., Kalbitz S; Department of Infectious Diseases/Tropical Medicine, Nephrology and Rheumatology, Hospital St. Georg, Leipzig, Germany., Fritzsche C; Department of Tropical Medicine and Infectious Diseases, Center for Internal Medicine, University of Rostock, Rostock, Germany., Hübner MP; Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Bonn, Germany., Trauth J; Division of Infectious Diseases, Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus Liebig University Giessen, Giessen, Germany., Jensen BO; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Luedde T; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany., Feldt T; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany. |
المصدر: | Infection [Infection] 2024 Apr; Vol. 52 (2), pp. 471-482. Date of Electronic Publication: 2023 Oct 24. |
نوع المنشور: | Review; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Heidelberg Country of Publication: Germany NLM ID: 0365307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0973 (Electronic) Linking ISSN: 03008126 NLM ISO Abbreviation: Infection Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2011- : Heidelberg : Springer Heidelberg Original Publication: München, Verlagsgesellschaft Otto Spatz. |
مواضيع طبية MeSH: | Lymphohistiocytosis, Hemophagocytic*/complications , Lymphohistiocytosis, Hemophagocytic*/diagnosis , Malaria*/complications , Communicable Diseases*, Humans ; Retrospective Studies ; Multiple Organ Failure |
مستخلص: | Background: Infection-associated secondary hemophagocytic lymphohistiocytosis (sHLH) is a potentially life-threatening hyperinflammatory condition caused by various infectious diseases. Malaria has rarely been described as trigger. The aim of this study is to collect data on frequency, clinical spectrum, and outcome of sHLH induced by malaria. Methods: We collected case numbers on malaria and malaria-associated sHLH from specialized centers in Germany from 2015 to 2022. In addition, we conducted a literature search on published cases of malaria-associated sHLH and systematically analyzed the literature regarding clinical and diagnostic criteria. Results: We obtained data from 13 centers treating 1461 malaria cases with different Plasmodium species, of which 5 patients (0.34%) also were diagnosed with sHLH. The literature search revealed detailed case reports from further 51 patients and case series comprising the description of further 24 patients with malaria-associated sHLH. Most cases (48/80; 60%) were reported from Asia. The median time interval between onset of malaria symptoms and hospital admission was 7 days. Severe complications of sHLH were documented in 36% (20/56) of patients, including two patients with multiple organ failure in our case series. Only 41% (23/56) of patients received specific treatment for sHLH, nevertheless the mortality rate (CFR) of 5% is lower compared to the CFR reported for sHLH triggered by other infectious diseases (e.g., 25% in sHLH due to EBV infection). Conclusion: Malaria-associated sHLH appears to have a comparatively good prognosis but may still represent an underdiagnosed and potentially fatal complication of malaria, especially in resource-poor settings. (© 2023. The Author(s).) |
References: | Trop Parasitol. 2020 Jan-Jun;10(1):50-55. (PMID: 32775294) BMJ Case Rep. 2016 Jun 13;2016:. (PMID: 27298293) Cancer. 1979 Sep;44(3):993-1002. (PMID: 225008) J Pediatr Hematol Oncol. 2022 Jan 1;44(1):e253-e254. (PMID: 33306604) Malar J. 2016 Feb 19;15:105. (PMID: 26893220) Int J Infect Dis. 2020 Nov;100:382-385. (PMID: 32777582) Pediatr Hematol Oncol. 2004 Apr-May;21(3):267-72. (PMID: 15202166) Ann Hematol. 2015 Jan;94(1):161-3. (PMID: 24880248) Malar J. 2016 Sep 08;15:461. (PMID: 27609213) Ann Hematol. 2011 Apr;90(4):491-2. (PMID: 20721557) Trans R Soc Trop Med Hyg. 2001 Mar-Apr;95(2):179-82. (PMID: 11355555) J Pak Med Assoc. 1995 Nov;45(11):302-3. (PMID: 8920613) Blood. 2012 Jan 26;119(4):910. (PMID: 22389905) World J Clin Cases. 2021 Aug 6;9(22):6403-6409. (PMID: 34435005) Chonnam Med J. 2011 Dec;47(3):173-6. (PMID: 22247919) Ann Hematol. 2012 Aug;91(8):1329-30. (PMID: 22273840) Clin Lab Haematol. 2005 Oct;27(5):312-5. (PMID: 16178911) Am J Trop Med Hyg. 2023 Aug 14;109(3):608-610. (PMID: 37580024) Cureus. 2022 Aug 25;14(8):e28386. (PMID: 36171833) Postgrad Med J. 2013 Apr;89(1050):185-92. (PMID: 23243150) Crit Care. 2020 May 24;24(1):244. (PMID: 32448380) BMJ Case Rep. 2017 Aug 7;2017:. (PMID: 28784903) J Med Assoc Thai. 2000 Oct;83(10):1141-9. (PMID: 11143479) J Vector Borne Dis. 2014 Jun;51(2):144-6. (PMID: 24947224) Am J Hematol. 2003 Oct;74(2):127-30. (PMID: 14508800) Paediatr Int Child Health. 2015;35(4):333-6. (PMID: 26744159) Indian J Med Res. 2017 Mar;145(3):399-404. (PMID: 28749405) Tunis Med. 2019 Feb;97(2):379-382. (PMID: 31539098) Lancet Infect Dis. 2007 Dec;7(12):814-22. (PMID: 18045564) J Med Assoc Thai. 2002 Aug;85 Suppl 2:S530-41. (PMID: 12403229) J Family Community Med. 2009 May;16(2):71-3. (PMID: 23012194) Acta Haematol. 2000;103(4):224-5. (PMID: 11014899) Rheumatol Int. 2010 Jun;30(8):1099-101. (PMID: 19593570) Indian Pediatr. 2012 May;49(5):413-4. (PMID: 22700669) Med Mal Infect. 2017 Dec;47(8):569-570. (PMID: 28844807) J Infect Public Health. 2011 Aug;4(3):108-24. (PMID: 21843857) Malar J. 2018 Oct 30;17(1):399. (PMID: 30376868) Pediatr Blood Cancer. 2007 Feb;48(2):124-31. (PMID: 16937360) Pediatr Infect Dis J. 2002 Nov;21(11):1086-7. (PMID: 12458577) Mikrobiyol Bul. 2022 Oct;56(4):749-754. (PMID: 36458720) Indian J Malariol. 2002 Mar-Jun;39(1-2):18-25. (PMID: 14686106) Br J Haematol. 2000 Mar;108(4):832-3. (PMID: 10792290) Am J Trop Med Hyg. 2007 Jun;76(6):1016-8. (PMID: 17556603) Virol J. 2022 Jun 25;19(1):107. (PMID: 35752863) Travel Med Infect Dis. 2018 Jan - Feb;21:21-27. (PMID: 29225124) Transpl Infect Dis. 2018 Jun;20(3):e12887. (PMID: 29573075) Eur J Haematol. 2022 Aug;109(2):129-137. (PMID: 35434872) Lung India. 2015 Nov-Dec;32(6):593-601. (PMID: 26664166) Indian J Pathol Microbiol. 2004 Jul;47(3):348-50. (PMID: 16295421) Br J Haematol. 2020 Dec;191(5):652. (PMID: 33094847) Med Microbiol Immunol. 2014 Dec;203(6):383-93. (PMID: 24985035) Hematol J. 2004;5(5):449-50. (PMID: 15448674) Am J Hematol. 2023 Apr;98(4):690-691. (PMID: 36436131) Acta Paediatr. 2000 Mar;89(3):368-9. (PMID: 10772292) Clin Infect Dis. 2003 Apr 15;36(8):990-5. (PMID: 12684911) Int J Immunopathol Pharmacol. 2013 Apr-Jun;26(2):535-9. (PMID: 23755771) Nephrol Dial Transplant. 2008 Oct;23(10):3359-61. (PMID: 18676345) Am J Trop Med Hyg. 2022 Nov 14;107(6):1203-1209. (PMID: 36375456) Arthritis Rheumatol. 2014 Sep;66(9):2613-20. (PMID: 24782338) Trop Parasitol. 2021 Jan-Jun;11(1):46-48. (PMID: 34195061) Infect Drug Resist. 2022 Nov 11;15:6625-6629. (PMID: 36386416) Clin Case Rep. 2019 Sep 27;7(11):2076-2081. (PMID: 31788255) Ann Saudi Med. 2002 May-Jul;22(3-4):261-2. (PMID: 17159417) Indian J Pathol Microbiol. 2011 Jul-Sep;54(3):594-6. (PMID: 21934231) Clin Microbiol Infect. 2016 Mar;22(3):268.e1-8. (PMID: 26686809) Indian J Pathol Microbiol. 2017 Jan-Mar;60(1):137-138. (PMID: 28195117) Br J Haematol. 2016 Jul;174(2):203-17. (PMID: 27264204) J Vector Borne Dis. 2013 Dec;50(4):318-20. (PMID: 24499858) Tunis Med. 2014 Jul;92(7):515-6. (PMID: 25775301) Int J Hematol. 1996 Oct;64(3-4):263-6. (PMID: 8923789) Hematol Oncol Stem Cell Ther. 2018 Mar;11(1):34-37. (PMID: 27514010) Front Med. 2013 Dec;7(4):492-8. (PMID: 24127015) Case Rep Med. 2015;2015:696842. (PMID: 26504465) |
فهرسة مساهمة: | Keywords: Plasmodium; HLH; HScore; Malaria |
تواريخ الأحداث: | Date Created: 20231024 Date Completed: 20240321 Latest Revision: 20240323 |
رمز التحديث: | 20240323 |
مُعرف محوري في PubMed: | PMC10955030 |
DOI: | 10.1007/s15010-023-02104-w |
PMID: | 37875775 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1439-0973 |
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DOI: | 10.1007/s15010-023-02104-w |