دورية أكاديمية
A transcriptome study of p53-pathway related prognostic gene signature set in bladder cancer.
العنوان: | A transcriptome study of p53-pathway related prognostic gene signature set in bladder cancer. |
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المؤلفون: | Khan SM; Clinical Biochemistry and Translational Medicine Laboratory, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh., Das T; Systems Cell-Signalling Laboratory, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh., Chakraborty S; Systems Cell-Signalling Laboratory, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh., Choudhury AMAR; Department. Uro-Oncology, National Institute of Cancer Research Hospital, Bangladesh., Karim HF; Department. Uro-Oncology, National Institute of Cancer Research Hospital, Bangladesh., Mostofa MA; Department. Uro-Oncology, National Institute of Cancer Research Hospital, Bangladesh., Ahmed HU; Clinical Biochemistry and Translational Medicine Laboratory, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh., Hossain MA; Clinical Biochemistry and Translational Medicine Laboratory, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh., Le Calvez-Kelm F; Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC), 69372, Lyon, France., Hosen MI; Clinical Biochemistry and Translational Medicine Laboratory, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh., Shekhar HU; Clinical Biochemistry and Translational Medicine Laboratory, Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh. |
المصدر: | Heliyon [Heliyon] 2023 Oct 14; Vol. 9 (10), pp. e21058. Date of Electronic Publication: 2023 Oct 14 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: London : Elsevier Ltd, [2015]- |
مستخلص: | p53 pathway is important in tumorigenesis. However, no study has been performed to specifically investigate the role of p53 pathway genes in bladder cancer (BLCA). In this study, transcriptomics data of muscle invasive bladder cancer patients (n = 411) from The Cancer Genome Atlas (TCGA) were investigated. Using the hallmark p53 pathway gene set, the Non-Negative Matrix factorization (NMF) analysis identified two subtypes (C1 and C2). Clinical, survival, and immunological analysis were done to validate distinct characteristics of the subtypes. Pathway enrichment analysis showed the subtype C1 with poor prognosis having enrichment in genes of the immunity related pathways, where C2 subtype with better prognosis being enriched in genes of the steroid synthesis and drug metabolism pathways. A signature gene set consisting of MDGA2, GNLY, GGT2, UGT2B4, DLX1, and DSC1 was created followed by a risk model. Their expressions were analyzed in RNA extracted from the blood and matched tumor tissues of BLCA patients (n = 10). DSC1 had significant difference of expression (p = 0.005) between the blood and tumor tissues in our BLCA samples. Contrary to the usual normal bladder tissue to blood ratio, DLX1 expression was lower (p = 0.02734) in tumor tissues than in blood. Being the first research of p53 pathway related signature gene set in bladder cancer, this study potentially has a substantial impact on the development of biomarkers for BLCA. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 Published by Elsevier Ltd.) |
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معلومات مُعتمدة: | 001 International WHO_ World Health Organization |
فهرسة مساهمة: | Keywords: BLCA; Biomarker; DLX1; DSC1; Enrichment; NMF; Nomogram; Signature-set; TCGA; p53 |
تواريخ الأحداث: | Date Created: 20231025 Latest Revision: 20240324 |
رمز التحديث: | 20240324 |
مُعرف محوري في PubMed: | PMC10590981 |
DOI: | 10.1016/j.heliyon.2023.e21058 |
PMID: | 37876438 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2405-8440 |
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DOI: | 10.1016/j.heliyon.2023.e21058 |