دورية أكاديمية
Surface immobilized α-1 acid glycoprotein and collagen VI modulate mouse macrophage polarization and reduce the foreign body capsule.
| العنوان: | Surface immobilized α-1 acid glycoprotein and collagen VI modulate mouse macrophage polarization and reduce the foreign body capsule. |
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| المؤلفون: | Chen AC; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Ciridon W; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Creason S; Department of Bioengineering, University of Washington, Seattle, Washington, USA., Ratner BD; Department of Bioengineering, University of Washington, Seattle, Washington, USA. |
| المصدر: | Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2024 Aug; Vol. 112 (8), pp. 1241-1249. Date of Electronic Publication: 2023 Oct 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101234237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4965 (Electronic) Linking ISSN: 15493296 NLM ISO Abbreviation: J Biomed Mater Res A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hoboken, NJ : John Wiley & Sons, c2002- |
| مواضيع طبية MeSH: | Macrophages*/metabolism , Macrophages*/drug effects , Foreign-Body Reaction* , Orosomucoid*/metabolism , Cell Polarity*/drug effects, Animals ; Mice ; Surface Properties ; Immobilized Proteins/pharmacology ; Polyhydroxyethyl Methacrylate/chemistry ; Mice, Inbred C57BL ; Lipopolysaccharides/pharmacology |
| مستخلص: | Macrophages are widely recognized in modulating the foreign body response, and the manner in which they do so largely depends on their activation state, often referred to as their polarization. This preliminary study demonstrates that surface immobilized α-1 acid glycoprotein (AGP), as well as collagen VI (Col6) in conjunction with AGP, can direct macrophages towards the M2 polarization state in vitro and modify the foreign body response in vivo. AGP and Col6 are immobilized onto poly(2-hydroxyethyl methacrylate) (pHEMA) surfaces using carbonyl diimidazole chemistry. Mouse bone marrow derived macrophages are cultured on modified surfaces with or without lipopolysaccharide stimulation. Surface modified pHEMA discs are implanted subcutaneously into mice to observe differences in the foreign body response. After stimulation with lipopolysaccharide, macrophages cultured on AGP or Col6 modified surfaces showed a reduction in TNF-α expression compared to controls. Arg1 expression was also increased in macrophages cultured on modified surfaces. Explanted tissues showed that the foreign body capsule around implants with AGP or AGP and Col6 modification had reduced thickness, while also being more highly vascularized. These data demonstrate that α-1 acid glycoprotein and collagen VI could potentially be used for the surface modification of medical devices to influence macrophage polarization leading to a reduced and modulated foreign body response. (© 2023 Wiley Periodicals LLC.) |
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| معلومات مُعتمدة: | Juvenile Diabetes Research Foundation International; National Science Foundation |
| فهرسة مساهمة: | Keywords: foreign body capsule; foreign body reaction; macrophage polarization; plasma deposition; surface modification |
| المشرفين على المادة: | 0 (Orosomucoid) 0 (Immobilized Proteins) 25249-16-5 (Polyhydroxyethyl Methacrylate) 0 (Lipopolysaccharides) |
| تواريخ الأحداث: | Date Created: 20231025 Date Completed: 20240618 Latest Revision: 20240703 |
| رمز التحديث: | 20240703 |
| DOI: | 10.1002/jbm.a.37627 |
| PMID: | 37877518 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1552-4965 |
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| DOI: | 10.1002/jbm.a.37627 |