دورية أكاديمية
Metabolomic Analysis and in Vitro Investigation of the Biological Properties of a By-Product Derived from Vicia faba.
العنوان: | Metabolomic Analysis and in Vitro Investigation of the Biological Properties of a By-Product Derived from Vicia faba. |
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المؤلفون: | Raoof GFA; Pharmacognosy Department, Pharmaceutical and Drug Research Industries Institute, National Research Centre, Dokki, Giza, 12622, Egypt., El-Anssary AA; Pharmacognosy Department, Pharmaceutical and Drug Research Industries Institute, National Research Centre, Dokki, Giza, 12622, Egypt., Younis EA; Department of Therapeutic Chemistry, National Research Centre, Dokki, P.O. 12622, Giza, Egypt., Aly HF; Department of Therapeutic Chemistry, National Research Centre, Dokki, P.O. 12622, Giza, Egypt. |
المصدر: | Chemistry & biodiversity [Chem Biodivers] 2023 Dec; Vol. 20 (12), pp. e202301095. Date of Electronic Publication: 2023 Nov 15. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
مواضيع طبية MeSH: | Vicia faba*/chemistry , Fabaceae*, Antioxidants/chemistry ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Acetylcholinesterase ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Rutin/pharmacology ; Carbohydrates |
مستخلص: | By-products from plant sources are recently regarded as a valuable source of bioactive compounds. In this regard, the present study aims to assess the bioactivities of the 70 % MeOH extract obtained from Vicia faba peels and analyze its metabolomic profile. Acetylcholinesterase and carbohydrate metabolizing enzymes inhibitory activities of the plant extract were assayed using quantitative colorimetric tests. Antioxidant activity was estimated by DPPH assay, and cytotoxic activity was evaluated against normal fibroblast skin cells (1-BJ1). Ninety-one metabolites were tentatively identified using ultra-high-performance liquid chromatography (UHPLC) hyphenated with quadrupole-time-of-flight tandem mass spectrometry (QTOF-MS). Most of these compounds were described for the first time in the plant. In addition, catechin, rutin, quercitrin, and rhamnetin were isolated from the plant extract. The plant extract and the isolated compounds possessed no cytotoxic activity on (1-BJ1), while they exhibited anticholinesterase with the highest activity for 70 % MeOH extract (IC (© 2023 Wiley-VHCA AG, Zurich, Switzerland.) |
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معلومات مُعتمدة: | National Research Centre |
فهرسة مساهمة: | Keywords: Anticholinesterase; Vicia faba peels extract; antidiabetic; food by-products; metabolomic profile |
المشرفين على المادة: | 0 (Antioxidants) 0 (Cholinesterase Inhibitors) EC 3.1.1.7 (Acetylcholinesterase) 0 (Plant Extracts) 5G06TVY3R7 (Rutin) 0 (Carbohydrates) |
تواريخ الأحداث: | Date Created: 20231025 Date Completed: 20231221 Latest Revision: 20231221 |
رمز التحديث: | 20231221 |
DOI: | 10.1002/cbdv.202301095 |
PMID: | 37878681 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1612-1880 |
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DOI: | 10.1002/cbdv.202301095 |