Naturally menstruating women exhibit lower cardiovagal baroreflex sensitivity than oral contraceptive users during the lower hormone phase.

التفاصيل البيبلوغرافية
العنوان:	Naturally menstruating women exhibit lower cardiovagal baroreflex sensitivity than oral contraceptive users during the lower hormone phase.
المؤلفون:	Mascone SE; Department of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland, USA., Jacob DW; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA., Eagan LE; Department of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland, USA., Harper JL; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA., Limberg JK; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA., Ranadive SM; Department of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland, USA.
المصدر:	Experimental physiology [Exp Physiol] 2023 Dec; Vol. 108 (12), pp. 1481-1489. Date of Electronic Publication: 2023 Oct 25.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة:	English
بيانات الدورية:	Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9002940 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-445X (Electronic) Linking ISSN: 09580670 NLM ISO Abbreviation: Exp Physiol Subsets: MEDLINE
أسماء مطبوعة:	Publication: Cambridge, Eng : Wiley-Blackwell Original Publication: Cambridge ; New York, NY, USA : Published for the Physiological Society by Cambridge University Press, c1990-
مواضيع طبية MeSH:	Progesterone* , Menstruation*, Humans ; Female ; Young Adult ; Adult ; Baroreflex ; Estradiol ; Contraceptives, Oral ; Estrogens
مستخلص:	The present study evaluated cardiovagal baroreflex sensitivity (BRS) across the menstrual/pill cycle in naturally menstruating women (NAT women) and women using oral hormonal contraceptives (OCP women). In 21 NAT women (23 ± 4 years old) and 22 OCP women (23 ± 3 years old), cardiovagal BRS and circulating concentrations of estradiol and progesterone were evaluated during the lower hormone (early follicular/placebo pill) and higher hormone (late follicular to early luteal/active pill) phases. During the lower hormone phase, cardiovagal BRS up, down and mean gain were lower in NAT women (15.6 ± 8.3, 15.2 ± 6.1 and 15.1 ± 7.1 ms/mmHg) compared with OCP women (24.7 ± 9.4, 22.9 ± 8.0 and 23.0 ± 8.0 ms/mmHg) (P = 0.003, P = 0.002 and P = 0.003, respectively), and higher oestrogen (R ² = 0.15, P = 0.024), but not progesterone (R ² = 0.06, P = 0.18), concentrations were predictive of lower BRS mean gain. During the higher hormone phase, higher progesterone concentrations were predictive of lower BRS mean gain (R ² = 0.12, P = 0.024). A multivariate regression model revealed group (NAT or OCP) to be a significant predictor of cardiovagal BRS mean gain in the lower hormone phase when hormone concentrations were adjusted for (R ² = 0.36, P = 0.0044). The multivariate regression model was not significant during the higher hormone phase (P > 0.05). In summary, cardiovagal BRS is lower in NAT compared with OCP women during the lower hormone phase of the menstrual/pill cycle and might be associated with higher oestrogen concentrations. In contrast, during the higher hormone phase of the menstrual/OCP cycle, higher progesterone concentrations were predictive of lower cardiovagal BRS. NEW FINDINGS: What is the central question of this study? Does cardiovagal baroreflex sensitivity (BRS) differ between naturally menstruating women (NAT women) and women using oral contraceptives (OCP women)? What is the main finding and its importance? The main findings are as follows: (1) NAT women exhibit lower cardiovagal BRS than OCP women during the lower hormone phase of the menstrual or pill cycle; and (2) circulating oestrogen concentrations are significant predictors of cardiovagal BRS during the lower hormone phase, with higher oestrogen concentrations predicting lower BRS. The present data advance our understanding of the effect of endogenous ovarian hormones and OCP use on cardiovascular control mechanisms. (© 2023 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.)
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معلومات مُعتمدة:	K99 HL130339 United States HL NHLBI NIH HHS; R00 HL130339 United States HL NHLBI NIH HHS; R01 HL153523 United States HL NHLBI NIH HHS; 909014 United States AHA American Heart Association-American Stroke Association
فهرسة مساهمة:	Keywords: baroreflex sensitivity; blood pressure regulation; sex hormones
المشرفين على المادة:	4G7DS2Q64Y (Progesterone) 4TI98Z838E (Estradiol) 0 (Contraceptives, Oral) 0 (Estrogens)
تواريخ الأحداث:	Date Created: 20231025 Date Completed: 20231204 Latest Revision: 20240410
رمز التحديث:	20240410
مُعرف محوري في PubMed:	PMC10843041
DOI:	10.1113/EP091394
PMID:	37878751
قاعدة البيانات:	MEDLINE

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تدمد:	1469-445X
DOI:	10.1113/EP091394