دورية أكاديمية
أعرض في EDS

Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome.

التفاصيل البيبلوغرافية
العنوان: Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome.
المؤلفون: Doan KD; Department of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, PA, USA., Akinsanya A; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 W 11th St, Indianapolis, IN, 46202, USA., Kuhar M; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 W 11th St, Indianapolis, IN, 46202, USA., Mesa H; Department of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, PA, USA. hmesa@iu.edu.; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 W 11th St, Indianapolis, IN, 46202, USA. hmesa@iu.edu.
المصدر: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology [Allergy Asthma Clin Immunol] 2023 Oct 25; Vol. 19 (1), pp. 92. Date of Electronic Publication: 2023 Oct 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Country of Publication: England NLM ID: 101244313 Publication Model: Electronic Cited Medium: Print ISSN: 1710-1484 (Print) Linking ISSN: 17101484 NLM ISO Abbreviation: Allergy Asthma Clin Immunol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Oct. 2009- : London : BioMed Central
Original Publication: Hamilton, Ont. : BC Decker, c2004-
مستخلص: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare but severe and sometimes fatal adverse drug reaction that is known to occur with a number of antiepileptic drugs. It often follows a prolonged clinical course, which can worsen even after discontinuing the causative drug and administering steroid treatment. Failure to promptly identify the delayed involvement of vital organs, such as the heart and liver, may result in irreversible organ failure and death. We report a case of a presumed sudden death of a young woman who had a documented history of a protracted intermittent hypersensitivity reaction to lamotrigine. Postmortem examination revealed the presence of eosinophilic myocarditis and submassive hepatic necrosis diagnostic of fatal DRESS syndrome that progressed despite early discontinuation of the medication and improvement of dermatologic and hematologic symptoms following steroid therapy.
(© 2023. Canadian Society of Allergy & Clinical Immunology.)
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فهرسة مساهمة: Keywords: Autopsy; Drug hypersensitivity syndrome; Lamotrigine; Massive hepatic necrosis; Myocarditis; Thyroiditis
تواريخ الأحداث: Date Created: 20231026 Latest Revision: 20231118
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10601244
DOI: 10.1186/s13223-023-00848-6
PMID: 37880699
قاعدة البيانات: MEDLINE
الوصف
تدمد:1710-1484
DOI:10.1186/s13223-023-00848-6