دورية أكاديمية
Programmable late-stage functionalization of bridge-substituted bicyclo[1.1.1]pentane bis-boronates.
| العنوان: | Programmable late-stage functionalization of bridge-substituted bicyclo[1.1.1]pentane bis-boronates. |
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| المؤلفون: | Yang Y; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Tsien J; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Dykstra R; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA., Chen SJ; Department of Discovery Chemistry, Merck & Co., Inc., South San Francisco, CA, USA., Wang JB; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Merchant RR; Department of Discovery Chemistry, Merck & Co., Inc., South San Francisco, CA, USA., Hughes JME; Department of Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Peters BK; Department of Process Research and Development, Merck & Co., Inc., Rahway, NJ, USA., Gutierrez O; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA. og.labs@tamu.edu.; Department of Chemistry, Texas A&M University, College Station, TX, USA. og.labs@tamu.edu., Qin T; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA. tian.qin@utsouthwestern.edu. |
| المصدر: | Nature chemistry [Nat Chem] 2024 Feb; Vol. 16 (2), pp. 285-293. Date of Electronic Publication: 2023 Oct 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: PubMed not MEDLINE; MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Pub. Group |
| مستخلص: | Modular functionalization enables versatile exploration of chemical space and has been broadly applied in structure-activity relationship (SAR) studies of aromatic scaffolds during drug discovery. Recently, the bicyclo[1.1.1]pentane (BCP) motif has increasingly received attention as a bioisosteric replacement of benzene rings due to its ability to improve the physicochemical properties of prospective drug candidates, but studying the SARs of C (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.) |
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| معلومات مُعتمدة: | R01 GM141088 United States GM NIGMS NIH HHS; R35 GM137797 United States GM NIGMS NIH HHS |
| تواريخ الأحداث: | Date Created: 20231026 Latest Revision: 20240513 |
| رمز التحديث: | 20240514 |
| مُعرف محوري في PubMed: | PMC10922318 |
| DOI: | 10.1038/s41557-023-01342-7 |
| PMID: | 37884667 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1038/s41557-023-01342-7 |