Obesity Modifies Clinical Outcomes of Right Ventricular Dysfunction.

التفاصيل البيبلوغرافية
العنوان:	Obesity Modifies Clinical Outcomes of Right Ventricular Dysfunction.
المؤلفون:	Ma JI; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (J.I.M., E.P., M.H.P.)., Zern EK; Providence Heart Institute, Center for Cardiovascular Analytics, Research, and Data Science (CARDS), Providence St. Joseph Health, Portland, OR (E.K.Z.)., Parekh JK; Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (J.K.P., N.O., N.J., D.W., J.E.H.)., Owunna N; Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (J.K.P., N.O., N.J., D.W., J.E.H.)., Jiang N; Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (J.K.P., N.O., N.J., D.W., J.E.H.)., Wang D; Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (J.K.P., N.O., N.J., D.W., J.E.H.).; Department of Biostatistics, Boston University School of Public Health, MA (D.W.)., Rambarat PK; Division of Cardiology, Duke University Medical Center, Durham, NC (P.K.R.)., Pomerantsev E; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (J.I.M., E.P., M.H.P.)., Picard MH; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (J.I.M., E.P., M.H.P.)., Ho JE; Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA (J.K.P., N.O., N.J., D.W., J.E.H.).
المصدر:	Circulation. Heart failure [Circ Heart Fail] 2023 Nov; Vol. 16 (11), pp. e010524. Date of Electronic Publication: 2023 Oct 27.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101479941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-3297 (Electronic) Linking ISSN: 19413289 NLM ISO Abbreviation: Circ Heart Fail Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins
مواضيع طبية MeSH:	Ventricular Dysfunction, Right* , Heart Failure* , Stroke*, Humans ; Female ; Middle Aged ; Male ; Retrospective Studies ; Pulmonary Artery ; Obesity/complications ; Ventricular Function, Right
مستخلص:	Background: Right ventricular (RV) dysfunction is associated with increased mortality across a spectrum of cardiovascular diseases. The role of obesity in RV dysfunction and adverse outcomes is unclear. Methods: We examined patients undergoing right heart catheterization between 2005 and 2016 in a hospital-based cohort. Linear regression was used to examine the association of obesity with hemodynamic indices of RV dysfunction (pulmonary artery pulsatility index, right atrial pressure:pulmonary capillary wedge pressure ratio, RV stroke work index). Cox models were used to examine the association of RV function measures with clinical outcomes. Results: Among 8285 patients (mean age, 63 years; 40% women), higher body mass index was associated with worse indices of RV dysfunction, including lower pulmonary artery pulsatility index (β, -0.23; SE, 0.01; P <0.001), higher right atrium:pulmonary capillary wedge pressure ratio (β, 0.25; SE, 0.01; P <0.001), and lower RV stroke work index (β, -0.05; SE, 0.01; P <0.001). Over median of 7.3 years of follow-up, we observed 3006 mortality and 2004 heart failure hospitalization events. RV dysfunction was associated with a greater risk of mortality (eg, pulmonary artery pulsatility index:hazard ratio, 1.11 per 1-SD increase [95% CI, 1.04-1.18]), with similar associations with risk of heart failure hospitalization. Body mass index modified the effect of RV dysfunction on all-cause mortality ( P interaction ≤0.005 for PAPi and RA:PCWP ratio), such that the effect of RV dysfunction was more pronounced at higher body mass index. Conclusions: Patients with obesity had worse hemodynamic measured indices of RV function across a broad hospital-based sample. While RV dysfunction was associated with worse clinical outcomes including mortality and heart failure hospitalization, this association was especially pronounced among individuals with higher body mass index. Competing Interests: Disclosures None.
التعليقات:	Update of: medRxiv. 2023 Jan 18;:. (PMID: 36711542)
References:	J Am Coll Cardiol. 2006 Feb 7;47(3):611-6. (PMID: 16458145) Circ Heart Fail. 2022 Feb;15(2):e009085. (PMID: 35135302) Echocardiography. 2016 Jun;33(6):854-61. (PMID: 26825487) Circulation. 2021 May 25;143(21):e984-e1010. (PMID: 33882682) J Card Fail. 2020 Apr;26(4):352-359. (PMID: 31981694) Eur J Heart Fail. 2018 Jan;20(1):16-37. (PMID: 29044932) Cardiorenal Med. 2018;8(2):123-129. (PMID: 29617005) N Engl J Med. 2002 Aug 1;347(5):305-13. (PMID: 12151467) J Card Fail. 2021 Oct;27(10):1061-1072. (PMID: 34625126) N Engl J Med. 2021 Mar 18;384(11):989-1002. (PMID: 33567185) Am Heart J. 2018 May;199:31-36. (PMID: 29754663) Intensive Care Med. 2018 May;44(5):588-597. (PMID: 29671040) Chest. 2012 Feb;141(2):388-395. (PMID: 21868467) Eur J Clin Invest. 2007 Apr;37(4):270-5. (PMID: 17373962) J Am Coll Cardiol. 2008 Nov 25;52(22):1793-9. (PMID: 19022158) Circulation. 2018 Aug 21;138(8):809-822. (PMID: 29500246) Methods Mol Biol. 2017;1527:297-309. (PMID: 28116725) Circulation. 2002 Sep 24;106(12 Suppl 1):I198-202. (PMID: 12354733) Curr Heart Fail Rep. 2013 Jun;10(2):109-21. (PMID: 23508767) CJC Open. 2021 Apr 30;3(9):1108-1116. (PMID: 34712937) N Engl J Med. 2022 Jul 21;387(3):205-216. (PMID: 35658024) JACC Heart Fail. 2020 Aug;8(8):667-676. (PMID: 32653444) JACC Heart Fail. 2019 Jul;7(7):574-585. (PMID: 31248569) J Card Fail. 2018 Jul;24(7):453-459. (PMID: 29597051) J Heart Lung Transplant. 2013 Mar;32(3):333-40. (PMID: 23415315) Obes Rev. 2012 Feb;13(2):136-49. (PMID: 22034852) Heart. 2020 Dec;106(23):1798-1804. (PMID: 32895314) J Cardiothorac Vasc Anesth. 2020 May;34(5):1220-1225. (PMID: 31653496) Minerva Cardioangiol. 2018 Oct;66(5):523-527. (PMID: 29642689) Circ J. 2020 Aug 25;84(9):1536-1543. (PMID: 32713875) N Engl J Med. 1987 Oct 22;317(17):1098. (PMID: 3657876) J Nutr Biochem. 2013 Dec;24(12):2003-15. (PMID: 24120291) Cardiorenal Med. 2019;9(2):83-91. (PMID: 30544108)
معلومات مُعتمدة:	K24 HL153669 United States HL NHLBI NIH HHS; R01 HL134893 United States HL NHLBI NIH HHS; R01 HL140224 United States HL NHLBI NIH HHS; R01 HL160003 United States HL NHLBI NIH HHS
فهرسة مساهمة:	Keywords: heart failure; obesity; pulmonary hypertension
تواريخ الأحداث:	Date Created: 20231027 Date Completed: 20231127 Latest Revision: 20240401
رمز التحديث:	20240401
مُعرف محوري في PubMed:	PMC10841712
DOI:	10.1161/CIRCHEARTFAILURE.123.010524
PMID:	37886836
قاعدة البيانات:	MEDLINE

View record in Lippincott, Williams & Wilkins

Full Text Finder

الوصف
تدمد:	1941-3297
DOI:	10.1161/CIRCHEARTFAILURE.123.010524