دورية أكاديمية
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Cognitive Performance during the Development of Diabetes in the Zucker Diabetic Fatty Rat.

التفاصيل البيبلوغرافية
العنوان: Cognitive Performance during the Development of Diabetes in the Zucker Diabetic Fatty Rat.
المؤلفون: Spoelder M; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., Bright Y; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., Morrison MC; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Sylviusweg 71, 2333 CE Leiden, The Netherlands., van Kempen V; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., de Groodt L; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., Begalli M; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., Schuijt N; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., Kruiger E; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands., Bulthuis R; Metris B.V., Kruisweg 829c, 2132 NG Hoofddorp, The Netherlands., Gross G; Medical and Scientific Affairs, Reckitt|Mead Johnson Nutrition Institute, Middenkampweg 2, 6545 CJ Nijmegen, The Netherlands., Kleemann R; Department of Metabolic Health Research, Netherlands Organisation for Applied Scientific Research (TNO), Sylviusweg 71, 2333 CE Leiden, The Netherlands., van Diepen JA; Medical and Scientific Affairs, Reckitt|Mead Johnson Nutrition Institute, Middenkampweg 2, 6545 CJ Nijmegen, The Netherlands., Homberg JR; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
المصدر: Cells [Cells] 2023 Oct 16; Vol. 12 (20). Date of Electronic Publication: 2023 Oct 16.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/metabolism, Rats ; Animals ; Rats, Zucker ; Rats, Long-Evans ; Obesity/metabolism ; Insulin/metabolism ; Cognition
مستخلص: Increased insulin levels may support the development of neural circuits involved in cognition, while chronic mild inflammation may also result in cognitive impairment. This study aimed to gain more insight into whether cognition is already impacted during adolescence in a genetic rat model for obesity and type 2 diabetes. Visual discrimination learning throughout adolescence and the level of motivation during early adulthood were investigated in Zucker Diabetic Fatty (ZDF) obese and ZDF lean rats using operant touchscreens. Blood glucose, insulin, and lipids were longitudinally analyzed. Histological analyses were performed in the liver, white adipose tissues, and the prefrontal cortex. Prior to the experiments with the genetic ZDF research model, all experimental assays were performed in two groups of outbred Long Evans rats to investigate the effect of different feeding circumstances. Adolescent ZDF obese rats outperformed ZDF lean rats on visual discrimination performance. During the longitudinal cognitive testing period, insulin levels sharply increased over weeks in ZDF obese rats and were significantly enhanced from 6 weeks of age onwards. Early signs of liver steatosis and enlarged adipocytes in white adipose tissue were observed in early adult ZDF obese rats. Histological analyses in early adulthood showed no group differences in the number of prefrontal cortex neurons and microglia, nor PSD95 and SIRT1 mRNA expression levels. Together, our data show that adolescent ZDF obese rats even display enhanced cognition despite their early diabetic profile.
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فهرسة مساهمة: Keywords: adolescence; cognition; diabetes; inflammation; insulin
المشرفين على المادة: 0 (Insulin)
تواريخ الأحداث: Date Created: 20231027 Date Completed: 20231030 Latest Revision: 20231108
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10605915
DOI: 10.3390/cells12202463
PMID: 37887307
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells12202463