دورية أكاديمية
أعرض في EDS

Linkage between Psychological Factors and Response to Immune Checkpoint Inhibitor Therapy: A Preliminary Study.

التفاصيل البيبلوغرافية
العنوان: Linkage between Psychological Factors and Response to Immune Checkpoint Inhibitor Therapy: A Preliminary Study.
المؤلفون: Cohen M; School of Social Work, University of Haifa, Haifa 3498838, Israel., Shamay Y; Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3109601, Israel., Czamanski-Cohen J; Emili Sagol Creative Arts Therapies Research Center, School of Creative Arts Therapies, University of Haifa, Haifa 3498838, Israel., Shulman K; Carmel Medical Center, Haifa 3436212, Israel.; Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3109601, Israel.; Lin Medical Center, Haifa 6688304, Israel., Keren Rosenberg S; Lin Medical Center, Haifa 6688304, Israel., Abu-Amna M; Cancer Center, Emek Medical Center, Afula 1834111, Israel., Turgeman I; Cancer Center, Emek Medical Center, Afula 1834111, Israel., Merkin Livshits L; Carmel Medical Center, Haifa 3436212, Israel.; Lin Medical Center, Haifa 6688304, Israel., Birenboim R; School of Social Work, University of Haifa, Haifa 3498838, Israel., Dines M; Emili Sagol Creative Arts Therapies Research Center, School of Creative Arts Therapies, University of Haifa, Haifa 3498838, Israel., Bar-Sela G; Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3109601, Israel.; Cancer Center, Emek Medical Center, Afula 1834111, Israel.
المصدر: Cells [Cells] 2023 Oct 17; Vol. 12 (20). Date of Electronic Publication: 2023 Oct 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Immune Checkpoint Inhibitors*/therapeutic use , Neoplasms*/complications, Humans ; Quality of Life ; Interleukin-6 ; Immunotherapy
مستخلص: Substantial evidence has accumulated showing that psychological distress affects immune regulation, the response to cancer treatment, and survival. The effect of psychological parameters on the effectiveness of immune checkpoint inhibitor (ICI) treatment has not yet been studied. This preliminary study aimed to (a) examine the associations between psychological factors and responses to ICI treatment and (b) assess the associations between psychological factors and blood measures of sPD-1, sCTLA-4, and cytokines that may alter the effect of ICI treatment. The participants were 62 individuals with advanced cancer, aged 18 years or older, who were candidates for ICI treatment as a new line of treatment. The participants answered questionnaires and provided blood samples and medical data prior to the start of ICI treatment and 3 months after. Perceived health status was positively associated with better responses to ICI treatment. In the subsample of participants with biomarkers, worse health-related quality of life was associated with higher IL-6 and sCTLA-4; emotional distress and sleep difficulties were associated with higher sCTLA-4; and better perceived health was associated with lower IL-6 and TNFα. sPD-1 was not associated with psychological measures. This preliminary study found for the first time that some psychological measures could be linked to responses to cancer treatment, possibly via pro-inflammatory cytokines and sCTLA-4.
References: Medicine (Baltimore). 2022 Sep 16;101(37):e30333. (PMID: 36123840)
Cancer Med. 2023 Feb;12(3):3343-3364. (PMID: 36602400)
J Transl Med. 2011 Jul 20;9:113. (PMID: 21774806)
Cancer. 2022 Jul 1;128(13):2504-2519. (PMID: 35417925)
Biology (Basel). 2021 Apr 13;10(4):. (PMID: 33924623)
Behav Sci (Basel). 2022 Dec 06;12(12):. (PMID: 36546981)
Immunotherapy. 2014;6(10):1073-84. (PMID: 25428646)
Eur J Ageing. 2005 Jun;2(2):149-158. (PMID: 28794727)
Cancers (Basel). 2020 May 30;12(6):. (PMID: 32486146)
Front Immunol. 2020 Oct 16;11:603157. (PMID: 33178229)
Am J Clin Oncol. 1982 Dec;5(6):649-55. (PMID: 7165009)
Sci Rep. 2022 Dec 9;12(1):21319. (PMID: 36494415)
Iran J Public Health. 2022 Sep;51(9):2089-2098. (PMID: 36743363)
Sleep. 2006 Jan;29(1):112-6. (PMID: 16453989)
Annu Rev Clin Psychol. 2023 May 9;19:331-359. (PMID: 36791765)
Int J Mol Sci. 2021 Aug 30;22(17):. (PMID: 34502325)
Cytokine. 2021 Jun;142:155478. (PMID: 33667962)
Front Immunol. 2022 Mar 21;13:827921. (PMID: 35386715)
J Gerontol B Psychol Sci Soc Sci. 2000 Mar;55(2):P107-16. (PMID: 10794189)
Front Immunol. 2022 Aug 22;13:884592. (PMID: 36072577)
J Clin Med. 2022 Jun 06;11(11):. (PMID: 35683629)
Exp Ther Med. 2020 Dec;20(6):211. (PMID: 33149775)
BMC Cancer. 2020 Dec 3;20(1):1185. (PMID: 33272262)
Eur J Cancer. 2021 Dec;159:154-166. (PMID: 34753012)
J Natl Cancer Inst. 1993 Mar 3;85(5):365-76. (PMID: 8433390)
Cancer Immunol Immunother. 2019 Jan;68(1):97-107. (PMID: 30311027)
Health Rep. 2001 Dec;13(1):35-52. (PMID: 15069807)
Int J Psychiatry Med. 2011;42(2):117-31. (PMID: 22409092)
Cancers (Basel). 2020 Dec 03;12(12):. (PMID: 33287347)
SSM Popul Health. 2021 Sep 06;16:100911. (PMID: 34660874)
Cytokine. 2021 Feb;138:155363. (PMID: 33264749)
Mol Psychiatry. 2020 Dec;25(12):3186-3197. (PMID: 32820237)
Biomedicines. 2021 Dec 16;9(12):. (PMID: 34944745)
Front Immunol. 2020 Nov 19;11:587460. (PMID: 33329567)
Arch Gerontol Geriatr. 2020 Sep - Oct;90:104169. (PMID: 32645561)
EBioMedicine. 2022 Sep;83:104235. (PMID: 36007304)
Int J Psychophysiol. 2020 Dec;158:96-102. (PMID: 33080293)
Dialogues Clin Neurosci. 2014 Jun;16(2):137-45. (PMID: 25152653)
Lancet Oncol. 2017 Mar;18(3):e143-e152. (PMID: 28271869)
Folia Med (Plovdiv). 2022 Aug 31;64(4):572-580. (PMID: 36045466)
PLoS One. 2020 Jan 24;15(1):e0227344. (PMID: 31978145)
Thorac Cancer. 2022 Jan;13(2):219-227. (PMID: 34825500)
Clin Pract. 2022 Dec 27;13(1):22-40. (PMID: 36648843)
Eur J Heart Fail. 2008 Oct;10(10):1040-7. (PMID: 18693135)
Crit Rev Oncol Hematol. 2019 Nov;143:148-152. (PMID: 31675543)
Future Oncol. 2022 Oct;18(32):3667-3675. (PMID: 36200533)
Psychosomatics. 2001 May-Jun;42(3):241-6. (PMID: 11351113)
فهرسة مساهمة: Keywords: CTLA-4; PD-1; cancer; cytokines; emotional distress; health-related quality of life; immune checkpoint inhibitor therapy
المشرفين على المادة: 0 (Immune Checkpoint Inhibitors)
0 (Interleukin-6)
تواريخ الأحداث: Date Created: 20231027 Date Completed: 20231030 Latest Revision: 20231112
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC10605722
DOI: 10.3390/cells12202471
PMID: 37887315
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells12202471