دورية أكاديمية
أعرض في EDS

Exhaled Breath Analysis Using Selected Ion Flow Tube Mass Spectrometry and Disease Severity in Heart Failure.

التفاصيل البيبلوغرافية
العنوان: Exhaled Breath Analysis Using Selected Ion Flow Tube Mass Spectrometry and Disease Severity in Heart Failure.
المؤلفون: Tang WHW; Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH 44195, USA., Tranchito L; Endocrinology & Metabolism Institute, Cleveland Clinic, Cleveland, OH 44195, USA., Albert C; Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH 44195, USA., Gul ZG; Department of Surgery, Washington University School of Medicine at St Louis, St Louis, MO 63110, USA., Cikach FS Jr; Heart Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH 44195, USA., Grove D; Department of Inflammation and Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.; Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USA., Wu Y; Department of Mathematics, Cleveland State University, Cleveland, OH 44195, USA., Dweik RA; Department of Inflammation and Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.; Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
المصدر: Metabolites [Metabolites] 2023 Oct 03; Vol. 13 (10). Date of Electronic Publication: 2023 Oct 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مستخلص: Exhaled breath volatile organic compounds (VOCs) are elevated in heart failure (HF). The ability of VOCs to predict long term cardiovascular mortality and morbidity has not been independently verified. In 55 patients admitted with acute decompensated heart failure (ADHF), we measured exhaled breath acetone and pentane levels upon admission and after 48 h of diuresis. In a separate cohort of 51 cardiac patients undergoing cardiopulmonary exercise testing (CPET), we measured exhaled breath acetone and pentane levels before and at peak exercise. In the ADHF cohort, admission acetone levels correlated with lower left ventricular ejection fraction (LVEF, r = -0.297, p = 0.035). Greater weight loss with diuretic therapy correlated with a greater reduction in both acetone levels (r = -0.398, p = 0.003) and pentane levels (r = -0.309, p = 0.021). In patients with above-median weight loss (≥4.5 kg), patients demonstrated significantly greater percentage reduction in acetone (59% reduction vs. 7% increase, p < 0.001) and pentane (23% reduction vs. 2% reduction, p = 0.008). In the CPET cohort, admission acetone and pentane levels correlated with higher VE/VCO2 (r = 0.39, p = 0.005), (r = 0.035, p = 0.014). However, there were no significant correlations between baseline or peak exercise acetone and pentane levels and peak VO2. In longitudinal follow-up with a median duration of 33 months, patients with elevated exhaled acetone and pentane levels experienced higher composite adverse events of death, ventricular assist device implantation, or orthotopic heart transplantation. In patients admitted with ADHF, higher exhaled breath acetone levels are associated with lower LVEF and poorer outcomes, and greater reductions in exhaled breath acetone and pentane tracked with greater weight loss. Exhaled acetone and pentane may be novel biomarkers in heart failure worthy of future investigation.
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معلومات مُعتمدة: R01 HL103931 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: acetone; exhaled breath; heart failure; pentane; selected ion flow tube mass spectrometry
تواريخ الأحداث: Date Created: 20231027 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10608518
DOI: 10.3390/metabo13101049
PMID: 37887374
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-1989
DOI:10.3390/metabo13101049