دورية أكاديمية
أعرض في EDS

Evaluation of Arterial Stiffness Parameters and the Growth Differentiation Factor-15 Level in Patients with Premature Myocardial Infarction.

التفاصيل البيبلوغرافية
العنوان: Evaluation of Arterial Stiffness Parameters and the Growth Differentiation Factor-15 Level in Patients with Premature Myocardial Infarction.
المؤلفون: Dogan Z; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey., Ileri C; Department of Cardiology, Kosuyolu Education and Research Hospital, Istanbul 34865, Turkey., Kay EA; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey., Sunbul M; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey., Gurel EY; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey., Özben Sadıc B; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey., Sayar N; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey., Ergun T; Department of Dermatology, Marmara University School of Medicine, Istanbul 34890, Turkey., Tigen KM; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey.
المصدر: Journal of personalized medicine [J Pers Med] 2023 Oct 13; Vol. 13 (10). Date of Electronic Publication: 2023 Oct 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2011-
مستخلص: Background: Myocardial infarction (MI) is increasing at a younger age. Growth differentiation factor-15 (GDF-15) has been implicated in several key mechanisms of atherogenesis. Arterial stiffness parameters, including pulse wave velocity (PWV) and the augmentation index (AIx), can indicate the presence or progression of atherosclerosis. The aim of this study is to evaluate the GDF-15 level and arterial stiffness parameters in patients with premature MI.
Method: Thirty patients aged ≤45 years (mean age: 39 ± 5 years, 23 male) who recovered from a MI and 15 age and sex-matched subjects were consecutively included. The serum GDF-15 concentration levels and arterial stiffness parameters of the patients and controls were measured.
Results: GDF-15 levels were significantly higher in patients with premature MI, while there were no significant differences in PWV and AIx between the groups. The GDF-15 level was correlated negatively with high-density lipoprotein (HDL) cholesterol and positively with uric acid levels. Both GDF-15 ( p = 0.046, odds ratio: 1.092, 95% confidence interval: 1.003-1.196) and HDL cholesterol ( p = 0.037, odds ratio: 0.925, 95% confidence interval: 0.859-0.995) were found as independent factors associated with premature MI.
Conclusions: GDF-15 could be a risk factor for premature MI. Further studies are needed to elucidate the central role of GDF-15 in the pathophysiology of early atherosclerosis and MI in the young population.
References: Eur J Med Res. 2013 Jun 24;18:19. (PMID: 23800095)
Balkan Med J. 2022 Mar 14;39(2):83-95. (PMID: 35330552)
J Am Heart Assoc. 2020 Feb 4;9(3):e014740. (PMID: 32003271)
Int J Vasc Med. 2012;2012:950130. (PMID: 22500238)
Arq Bras Cardiol. 2021 Mar;116(3):494-500. (PMID: 33566936)
Chin Med J (Engl). 2017 5th Jan 2017;130(1):77-82. (PMID: 28051027)
J Am Coll Cardiol. 2011 Apr 5;57(14):1511-22. (PMID: 21453829)
Aging Cell. 2010 Dec;9(6):1057-64. (PMID: 20854422)
Am Heart J. 2005 Jan;149(1):67-73. (PMID: 15660036)
Circ Cardiovasc Genet. 2009 Jun;2(3):286-92. (PMID: 20031597)
J Am Heart Assoc. 2012 Dec;1(6):e002550. (PMID: 23316317)
J Am Coll Cardiol. 2008 Jul 29;52(5):357-65. (PMID: 18652943)
BMC Cardiovasc Disord. 2016 May 06;16:82. (PMID: 27154403)
Cardiovasc Ther. 2016 Jun;34(3):138-43. (PMID: 26996787)
Cardiovasc Diabetol. 2020 Aug 3;19(1):120. (PMID: 32746821)
Clin Chem. 2021 Mar 31;67(4):653-661. (PMID: 33582779)
Future Sci OA. 2019 Aug 14;5(7):FSO406. (PMID: 31428452)
Lipids Health Dis. 2023 Mar 2;22(1):31. (PMID: 36864452)
J Diabetes Res. 2015;2015:490842. (PMID: 26273671)
Circ J. 2010 Nov;74(11):2257-62. (PMID: 20962429)
Am J Cardiol. 2019 Jul 1;124(1):8-13. (PMID: 31047655)
Hypertension. 2008 Feb;51(2):309-18. (PMID: 18158353)
Front Aging. 2022 Feb 09;3:837575. (PMID: 35821815)
Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):203-10. (PMID: 20966402)
Heart Lung Circ. 2016 Oct;25(10):955-60. (PMID: 27265644)
Coron Artery Dis. 2017 Dec;28(8):642-648. (PMID: 28692482)
Am J Hypertens. 2002 May;15(5):445-52. (PMID: 12022247)
Eur Heart J. 2016 Apr 21;37(16):1325-33. (PMID: 26417057)
Curr Opin Cardiol. 2015 Jul;30(4):422-31. (PMID: 26049393)
J Am Coll Cardiol. 2010 Mar 30;55(13):1318-27. (PMID: 20338492)
Circ Res. 2006 Feb 17;98(3):351-60. (PMID: 16397141)
Eur Heart J. 2008 Oct;29(19):2327-35. (PMID: 18664460)
Cytokine Growth Factor Rev. 2021 Feb;57:11-18. (PMID: 33317942)
PLoS One. 2014 Oct 15;9(10):e110034. (PMID: 25333969)
Circulation. 2018 Mar 20;137(12):e67-e492. (PMID: 29386200)
Front Cardiovasc Med. 2019 Apr 09;6:41. (PMID: 31024934)
Front Physiol. 2015 Dec 09;6:365. (PMID: 26696899)
J Am Coll Cardiol. 2014 Jul 29;64(4):337-45. (PMID: 25060366)
Geroscience. 2022 Apr;44(2):867-880. (PMID: 33961185)
J Forensic Leg Med. 2018 Aug;58:45-49. (PMID: 29730481)
Mayo Clin Proc. 2020 Jan;95(1):136-156. (PMID: 31902409)
Cureus. 2020 Jul 23;12(7):e9349. (PMID: 32742886)
Mayo Clin Proc Innov Qual Outcomes. 2021 Jun 23;5(4):783-794. (PMID: 34401655)
Angiology. 2022 Jan;73(1):9-17. (PMID: 33902350)
فهرسة مساهمة: Keywords: GDF-15; arterial stiffness; premature myocardial infarction; pulse wave velocity
تواريخ الأحداث: Date Created: 20231027 Latest Revision: 20231029
رمز التحديث: 20231029
مُعرف محوري في PubMed: PMC10608472
DOI: 10.3390/jpm13101489
PMID: 37888100
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-4426
DOI:10.3390/jpm13101489