دورية أكاديمية
Evaluation of Arterial Stiffness Parameters and the Growth Differentiation Factor-15 Level in Patients with Premature Myocardial Infarction.
العنوان: | Evaluation of Arterial Stiffness Parameters and the Growth Differentiation Factor-15 Level in Patients with Premature Myocardial Infarction. |
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المؤلفون: | Dogan Z; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey., Ileri C; Department of Cardiology, Kosuyolu Education and Research Hospital, Istanbul 34865, Turkey., Kay EA; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey., Sunbul M; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey., Gurel EY; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey., Özben Sadıc B; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey., Sayar N; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey., Ergun T; Department of Dermatology, Marmara University School of Medicine, Istanbul 34890, Turkey., Tigen KM; Department of Cardiology, Marmara University School of Medicine, Istanbul 34890, Turkey. |
المصدر: | Journal of personalized medicine [J Pers Med] 2023 Oct 13; Vol. 13 (10). Date of Electronic Publication: 2023 Oct 13. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, 2011- |
مستخلص: | Background: Myocardial infarction (MI) is increasing at a younger age. Growth differentiation factor-15 (GDF-15) has been implicated in several key mechanisms of atherogenesis. Arterial stiffness parameters, including pulse wave velocity (PWV) and the augmentation index (AIx), can indicate the presence or progression of atherosclerosis. The aim of this study is to evaluate the GDF-15 level and arterial stiffness parameters in patients with premature MI. Method: Thirty patients aged ≤45 years (mean age: 39 ± 5 years, 23 male) who recovered from a MI and 15 age and sex-matched subjects were consecutively included. The serum GDF-15 concentration levels and arterial stiffness parameters of the patients and controls were measured. Results: GDF-15 levels were significantly higher in patients with premature MI, while there were no significant differences in PWV and AIx between the groups. The GDF-15 level was correlated negatively with high-density lipoprotein (HDL) cholesterol and positively with uric acid levels. Both GDF-15 ( p = 0.046, odds ratio: 1.092, 95% confidence interval: 1.003-1.196) and HDL cholesterol ( p = 0.037, odds ratio: 0.925, 95% confidence interval: 0.859-0.995) were found as independent factors associated with premature MI. Conclusions: GDF-15 could be a risk factor for premature MI. Further studies are needed to elucidate the central role of GDF-15 in the pathophysiology of early atherosclerosis and MI in the young population. |
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فهرسة مساهمة: | Keywords: GDF-15; arterial stiffness; premature myocardial infarction; pulse wave velocity |
تواريخ الأحداث: | Date Created: 20231027 Latest Revision: 20231029 |
رمز التحديث: | 20231029 |
مُعرف محوري في PubMed: | PMC10608472 |
DOI: | 10.3390/jpm13101489 |
PMID: | 37888100 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2075-4426 |
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DOI: | 10.3390/jpm13101489 |