دورية أكاديمية
أعرض في EDS

Clinical and Biochemical Evaluation of the Use of Alb-PRF versus L-PRF in Mandibular Third Molar Extractions: A Split-Mouth Randomized Clinical Trial.

التفاصيل البيبلوغرافية
العنوان: Clinical and Biochemical Evaluation of the Use of Alb-PRF versus L-PRF in Mandibular Third Molar Extractions: A Split-Mouth Randomized Clinical Trial.
المؤلفون: Javid K; Graduate Program in Dentistry, Fluminense Federal University, Niterói 24020-140, Brazil., Mourão CF; Department of Periodontology, Tufts University School of Dental Medicine, Boston, MA 02111, USA., Mello-Machado RC; Department of Implant Dentistry, Universidade Iguaçu, Nova Iguaçu 26260-045, Brazil., Sartoretto SC; Department of Oral Surgery, Fluminense Federal University, Niterói 24020-140, Brazil., Torres M; Graduate Program in Dentistry, Fluminense Federal University, Niterói 24020-140, Brazil., Stellet Lourenço E; Graduate Program in Dentistry, Fluminense Federal University, Niterói 24020-140, Brazil., Leite PEC; Clinical Research Unit, Antonio Pedro Hospital, Fluminense Federal University, Niterói 24033-900, Brazil., Granjeiro JM; Department of Oral Surgery, Fluminense Federal University, Niterói 24020-140, Brazil., Alves GG; Department of Biotechnology, Fluminense Federal University, Niterói 24033-900, Brazil., Calasans-Maia MD; Department of Oral Surgery, Fluminense Federal University, Niterói 24020-140, Brazil.
المصدر: Journal of functional biomaterials [J Funct Biomater] 2023 Oct 10; Vol. 14 (10). Date of Electronic Publication: 2023 Oct 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101570734 Publication Model: Electronic Cited Medium: Print ISSN: 2079-4983 (Print) Linking ISSN: 20794983 NLM ISO Abbreviation: J Funct Biomater Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI AG
مستخلص: Bone tissue engineering seeks biomaterials that enable cell migration, angiogenesis, matrix deposition, and tissue regeneration. Blood concentrates like platelet-rich fibrin (L-PRF) offer a cost-effective source of cells and growth factors to enhance healing. The present study aimed to evaluate heated serum albumin with liquid PRF (Alb-PRF) and L-PRF clinically and biochemically after placement in dental sockets following mandibular third molar extraction. In a controlled, split-mouth study involving 10 volunteers, 20 extracted molars were treated with either Alb-PRF or L-PRF. Post-extraction, pain, trismus, infection presence, and swelling were measured. The concentrations of different analytes in the surgical sites were also examined. The data were statistically analyzed, with significance defined at p < 0.05 ( t -test). No significant difference was noted between the groups for pain and trismus, but Alb-PRF showed a significant reduction in swelling on day seven. The Alb-PRF group showed lower levels of pro-inflammatory cytokines (GM-CSF, IL-1b, IL-6, IFNy, IL-8, IL-15, RANTES, and MIP-1a) after seven days, with only higher expressions of MIP-1b, IL-1b, and MCP-1 found in the L-PRF group. Differences were observed in the release of analytes between L-PRF and Alb-PRF, with Alb-PRF significantly reducing edema after seven days. Alb-PRF reduced edema, while L-PRF increased inflammatory cytokines. When compared to L-PRF, Alb-PRF reduced edema and the release of inflammatory cytokines, suggesting promising effects in socket healing while underscoring the role of growth factors and cytokines in potential applications of blood concentrates.
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فهرسة مساهمة: Keywords: Alb-PRF; L-PRF; albumin; lower third molars; platelet-rich fibrin
تواريخ الأحداث: Date Created: 20231027 Latest Revision: 20231029
رمز التحديث: 20231029
مُعرف محوري في PubMed: PMC10607814
DOI: 10.3390/jfb14100505
PMID: 37888172
قاعدة البيانات: MEDLINE
الوصف
تدمد:2079-4983
DOI:10.3390/jfb14100505