دورية أكاديمية
Gut microbiome dynamics in index patients colonized with extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales after hospital discharge and their household contacts.
| العنوان: | Gut microbiome dynamics in index patients colonized with extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales after hospital discharge and their household contacts. |
|---|---|
| المؤلفون: | Top J; Department of Medical Microbiology, University Medical Center Utrecht , Utrecht, the Netherlands., Verschuuren TD; Mahidol Oxford Tropical Medicine Research Unit (MORU) , Bangkok, Thailand., Viveen MC; Department of Medical Microbiology, University Medical Center Utrecht , Utrecht, the Netherlands., Riccio ME; University of Geneva Hospitals and Faculty of Medicine, Infection Control Program, WHO Collaborating Center , Geneva, Switzerland., Harbarth S; University of Geneva Hospitals and Faculty of Medicine, Infection Control Program, WHO Collaborating Center , Geneva, Switzerland., Kluytmans JAJW; Department of Medical Microbiology, University Medical Center Utrecht , Utrecht, the Netherlands., Willems RJL; Department of Medical Microbiology, University Medical Center Utrecht , Utrecht, the Netherlands., Paganelli FL; Department of Medical Microbiology, University Medical Center Utrecht , Utrecht, the Netherlands. |
| المصدر: | Microbiology spectrum [Microbiol Spectr] 2023 Dec 12; Vol. 11 (6), pp. e0127523. Date of Electronic Publication: 2023 Oct 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : ASM Press, 2013- |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome*, Humans ; Patient Discharge ; beta-Lactamases ; Escherichia coli ; Klebsiella pneumoniae ; Hospitals ; Anti-Bacterial Agents |
| مستخلص: | Importance: Colonization with extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) often precedes infections and is therefore considered as a great threat for public health. Here, we studied the gut microbiome dynamics in eight index patients colonized with ESBL-PE after hospital discharge and the impact of exposure to this index patient on the gut microbiome dynamics of their household contacts. We showed that the microbiome composition from index patients is different from their household contacts upon hospital discharge and that, in some of the index patients, their microbiome composition over time shifted toward the composition of their household contacts. In contrast, household contacts showed a stable microbiome composition over time irrespective of low-level extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-Ec) or extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-Kp) gut colonization, suggesting that, in healthy microbiomes, colonization resistance is able to prevent ESBL-PE expansion. Competing Interests: The authors declare no conflict of interest. |
| فهرسة مساهمة: | Keywords: ESBL-Enterobacterales; gut microbiome dynamics; household contacts; index patient |
| المشرفين على المادة: | EC 3.5.2.6 (beta-Lactamases) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20231027 Date Completed: 20231216 Latest Revision: 20231216 |
| رمز التحديث: | 20231217 |
| مُعرف محوري في PubMed: | PMC10714770 |
| DOI: | 10.1128/spectrum.01275-23 |
| PMID: | 37888982 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2165-0497 |
|---|---|
| DOI: | 10.1128/spectrum.01275-23 |